COVID-19 mRNA Vaccines: Lessons Learned from the Registrational Trials and Global Vaccination Campaign
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 24, 2024
Our
understanding
of
COVID-19
vaccinations
and
their
impact
on
health
mortality
has
evolved
substantially
since
the
first
vaccine
rollouts.
Published
reports
from
original
randomized
phase
3
trials
concluded
that
mRNA
vaccines
could
greatly
reduce
symptoms.
In
interim,
problems
with
methods,
execution,
reporting
these
pivotal
have
emerged.
Re-analysis
Pfizer
trial
data
identified
statistically
significant
increases
in
serious
adverse
events
(SAEs)
group.
Numerous
SAEs
were
following
Emergency
Use
Authorization
(EUA),
including
death,
cancer,
cardiac
events,
various
autoimmune,
hematological,
reproductive,
neurological
disorders.
Furthermore,
products
never
underwent
adequate
safety
toxicological
testing
accordance
previously
established
scientific
standards.
Among
other
major
topics
addressed
this
narrative
review
are
published
analyses
harms
to
humans,
quality
control
issues
process-related
impurities,
mechanisms
underlying
(AEs),
immunologic
basis
for
inefficacy,
concerning
trends
based
registrational
data.
The
risk-benefit
imbalance
substantiated
by
evidence
date
contraindicates
further
booster
injections
suggests
that,
at
a
minimum,
should
be
removed
childhood
immunization
program
until
proper
studies
conducted.
Federal
agency
approval
blanket-coverage
population-wide
had
no
support
an
honest
assessment
all
relevant
commensurate
consideration
risks
versus
benefits.
Given
extensive,
well-documented
unacceptably
high
harm-to-reward
ratio,
we
urge
governments
endorse
global
moratorium
modified
questions
pertaining
causality,
residual
DNA,
aberrant
protein
production
answered.
Язык: Английский
“I can't see the forest for the ticks, uhm, trees …”: The role of online forums in parents' vaccination trajectories
Social Science & Medicine,
Год журнала:
2024,
Номер
357, С. 117183 - 117183
Опубликована: Авг. 5, 2024
When
it
comes
to
health-related
information-seeking
behavior,
online
communities
play
a
key
role
for
some
groups,
such
as
parents.
With
case
study
of
in
loosely
organized
vaccination
system,
that
Austria,
we
how
parents
make
use
prominent
forum
(parents.at)
their
trajectories
and
situate
this
analysis
its
socio-political
context.
Based
on
inductive
qualitative
relevant
threads
(n
=
27),
find
forums
three
ways:
First,
the
serves
platform
through
which
seek
orientation
fragmented
system.
Second,
offers
space
sharing,
collecting,
evaluating
different
forms
expertise.
In
doing
so,
carve
out
they
can
comfortably
put
lay
expertise
credentialed
par,
particularly
advice
peers.
Third,
basis,
deliberating
future
or
past
vaccination-related
decisions.
frequently
draw
idiosyncratic
notions
individual
risks
benefits.
These
practices
enable
accumulate
share
what
label
navigational
capital.
We
conclude
resort
spaces
both
subjective
need
and,
some,
result
dysfunction
national
childhood
program
little
Язык: Английский
Factors Associated with Parents’ COVID-19 Vaccination Decisions for Their Children in an Economically Marginalized, Diverse Community
Journal of Community Health,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 5, 2024
Язык: Английский
Factors associated with parental intentions to vaccinate 0-4-year-old children against COVID-19 in Canada: a cross-sectional study using the Childhood COVID-19 Immunization Coverage Survey (CCICS)
Israa Zareef,
Anna-Maria Frescura,
Sailly Dave
и другие.
BMC Public Health,
Год журнала:
2024,
Номер
24(1)
Опубликована: Дек. 18, 2024
Abstract
Background
The
objective
of
this
study
was
to
determine
the
factors
associated
with
low
or
no
parental
intention
vaccinate
children
0-4-years
in
Canada
a
COVID-19
vaccine
through
2022
Childhood
Immunization
Coverage
Survey
(CCICS).
CCICS
conducted
prior
introduction
and
recommendation
for
age
group.
Methods
Simple
multiple
logistic
regression
models
were
used
associations
between
sociodemographic
as
well
knowledge,
attitudes
beliefs
low/no
intentions
against
among
parents
0–4
years.
Results
Factors
included
being
male
(aOR:
2.0;
95%
CI:
2.0‒2.1)
compared
female;
30–39
(aOR
1.1;
1.1‒1.2)
40+;
Black
2.3,
2.2‒2.5),
East/Southeast
Asian
3.6,
3.3‒3.8),
having
ethnicities
1.3,
1.1‒1.6)
White
European
ethnicity;
living
rural
2.0,
1.9‒2.1)
urban
community;
total
2021
household
income
$60,000‒$79,999
CAD
1.4,
1.3‒1.5)
$150,000
above;
trusting
government
bodies
2.4;
1.1‒1.2),
international
media
1.9‒2.2)
information
about
vaccines
health
care
providers.
Conclusions
findings
demonstrate
that
several
impact
decision
years
COVID-19.
Future
research
should
focus
on
barriers
vaccination
how
most
appropriately
tailor
delivery
programs
specific
groups,
an
effort
narrow
gap
uptake
younger
children.
As
well,
messaging
specifically
be
targeted
who
have
lower
confidence
provide
correct
build
trust.
Язык: Английский
Parental Attitudes Toward Vaccination
Risk, systems and decisions,
Год журнала:
2024,
Номер
unknown, С. 415 - 426
Опубликована: Янв. 1, 2024
Язык: Английский
Attitudes toward COVID-19 and Other Vaccines: Comparing Parents to Other Adults, September 2022
Vaccines,
Год журнала:
2023,
Номер
11(12), С. 1735 - 1735
Опубликована: Ноя. 21, 2023
Few
analyses
of
COVID-19
vaccine
attitudes
also
cover
routine
vaccines
or
focus
on
parents.
In
this
cross-sectional
study,
we
surveyed
US
adults
in
September
2022,
immediately
following
the
authorization
updated
bivalent
boosters
for
but
before
their
children.
The
parents
were
compared
to
other
adults.
Fewer
up-to-date
than
(54%
vs.
67%),
even
after
adjusting
age,
education,
and
race/ethnicity
(Adjusted
Odds
Ratio:
0.58;
95%
Confidence
Interval:
0.45-0.76).
More
had
concerns
about
vaccines'
safety
children
(67%
58%;
aOR:
1.59;
95%CI:
1.23-2.06)
ingredients
(52%
45%;
1.41;
1.09-1.81),
more
perceived
be
no
worse
a
cold
flu
(51%
38%;
1.56;
1.22-2.01).
supported
school
requirements
57%;
0.75;
0.58-0.97)
high
coverage
among
friends
61%;
0.60;
0.46-0.78).
However,
three-quarters
intended
child
receive
all
routinely
recommended
vaccines,
whereas
only
half
themselves.
To
improve
parental
informed
decision-making,
public
health
must
ensure
pediatric
providers
have
resources
support
discussions
risks
benefits
with
patients'
Язык: Английский