Vaccine, Год журнала: 2024, Номер unknown, С. 125628 - 125628
Опубликована: Янв. 1, 2024
Язык: Английский
Vaccine, Год журнала: 2024, Номер 42, С. 125549 - 125549
Опубликована: Фев. 9, 2024
During the COVID-19 pandemic, candidate vaccines were being developed for potential use in United States on an unprecedented, accelerated schedule. It was anticipated that once available, under U.S. Food and Drug Administration (FDA) Emergency Use Authorization (EUA) or FDA approval, would be broadly used potentially administered to millions of individuals a short period time. Intensive monitoring post-EUA/licensure necessary timely detection assessment safety concerns. To address this, Centers Disease Control Prevention (CDC) convened Advisory Committee Immunization Practices (ACIP) work group focused solely vaccine safety, consisting independent experts representatives from federal agencies - ACIP Vaccine Safety Technical Work Group (VaST). This report provides overview organization activities VaST, summarizes data reviewed as part comprehensive effort monitor during highlights selected actions taken by CDC, ACIP, response accumulating post-authorization data. VaST regular meetings over course 29 months, November 2020 through April 2023; March 2023 issued EUAs six four different manufacturers subsequently licensed two these vaccines. The collaborated with ensure this worked closely Vaccines Group; VaST's assessments benefit-risk guidance vaccination policy. topics included those identified systems other scientific public interest. provided CDC's efforts, forum review several government systems, assured diverse scientists clinicians, external government, promptly In event future pandemic biological health emergency, model could strengthen monitoring, enhance confidence, increase transparency incorporation independent, non-government into process, strong collaboration among partners.
Язык: Английский
Процитировано
7
Journal of Infection and Public Health, Год журнала: 2025, Номер unknown, С. 102688 - 102688
Опубликована: Янв. 1, 2025
Vaccination has played a key role in limiting the impacts of COVID-19. Even though acute phase COVID-19 pandemic is now over, potential for substantial numbers cases and deaths due to novel SARS-CoV-2 variants remains. In Republic Korea, strategy vaccinating individuals high-risk groups annually began October 2023. We used mathematical modeling assess effectiveness alternative vaccination strategies under different assumptions about number available vaccine doses. An age-structured transmission model was developed using seropositivity data. Various scenarios were considered, taking into account effect undetected or unreported (with levels reporting by age group): S1: prioritizing towards oldest individuals; S2: youngest S3: spreading vaccines among all groups. Our analysis reveals three findings. First, administering older reduces deaths, while instead targeting younger infections. Second, with approximately 6,000,000 doses annually, it recommended that are prioritized vaccination, achieving reduction compared scenario without vaccination. Finally, since case detection (and subsequent isolation) affects transmission, cumulative found be affected substantially changes rate. conclusion, (facilitated contact tracing) both play important roles The approach presented here provides framework assessing limited supply.
Язык: Английский
Процитировано
0
Immunity Inflammation and Disease, Год журнала: 2025, Номер 13(4)
Опубликована: Апрель 1, 2025
ABSTRACT Background Renal transplant recipients are at higher risk of COVID‐19 infection due to chronic comorbidities and immunocompromised state. Limited information is available in Nepal regarding this among organ transplantation patients. Methods A retrospective cross‐sectional study was conducted on 601 patients assess the impact who underwent renal surgery Shahid Dharmabhakta National Transplant Center (SDNTC), Bhaktapur. All were confirmed through PCR tests included. self‐developed, semi‐structured telephone interview schedule utilized for data collection. Results Among responded our calls, more than a quarter (37.9%) diagnosed as positive. The mortality rate relatively low 5.7% overall, but significantly 14.9% those with Hypertension diabetes mellitus top two comorbid conditions. common reporting symptom fever followed by cough. Interestingly, 23.7% COVID‐19‐positive hospitalized, them, 72.2% admitted 2 days. Notably, 65.8% not vaccinated ones, only 17.1% fully vaccinated. most vaccine Vero Cell. There sixfold increased chance unvaccinated ones. However, there no significant association between age, sex, occupation vaccination status. Conclusion This highlights heightened vulnerability portion studied tested positive COVID‐19, notable these findings underscore critical role vaccination, considerable number unvaccinated.
Язык: Английский
Процитировано
0
Academic Pediatrics, Год журнала: 2024, Номер 24(7), С. 1038 - 1046
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
2
Vaccine, Год журнала: 2023, Номер 42, С. 125492 - 125492
Опубликована: Дек. 20, 2023
COVID-19 vaccines were originally authorized in the United States December 2020 on basis of safety, immunogenicity, and clinical efficacy data from randomized controlled trials (RCTs). However, real-world vaccine effectiveness (VE) are necessary to provide information how work populations not included RCTs (e.g., nursing home residents), against new SARS-CoV-2 variants, with increasing time since vaccination, levels prior infection. The goal CDC's VE program is timely robust support ongoing policy decisions implementation vaccination includes platforms study spectrum illness, infection critical illness. Challenges estimating include accurate ascertainment history, outcome status, changing rates infection, emergence appropriate interpretation absolute relative measures. CDC have played a pivotal role numerous 2021 will continue play key future as moves an emergency response routine schedule.
Язык: Английский
Процитировано
6
Journal of Lifestyle and SDGs Review, Год журнала: 2024, Номер 4(4), С. e03562 - e03562
Опубликована: Ноя. 22, 2024
Objectives: This paper aims to investigate the evolution of supply chain management (SCM) in globalization era, which is typified by focus on global supplier relationship systems and growth chains across national borders continents. Methods: The introduction mathematical models, include a broad range linear, integer, non-linear programming first section this paper. Location modeling transportation planning are two common applications for heuristic models. Although models best suited analytical problem solving, complex real-world issues frequently call basic assumptions. In simulation intricacies relationships between different variables represented equations, then an attempt made discuss comparative analysis results. Results: Once put into place, system always has lifespan that determined previously mentioned factors problems. It would be more accurate say all developed should reviewed regular basis any necessary adjustments maintain their functionality effectiveness. Conclusion: According paper, fiercely competitive food production market largely driven time-based competition, producer's or farmer's ability offer customer flexible responsive determines its edge. These businesses understand providing creative products outstanding service essential retaining clients opening up new revenue streams.
Язык: Английский
Процитировано
0
Vaccine, Год журнала: 2024, Номер unknown, С. 125628 - 125628
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0