Effect of wild-type vaccine doses on BA.5 hybrid immunity, disease severity, and XBB reinfection risk DOI Creative Commons
D Chen, Weihong Zhang, Bin Xiao

и другие.

Journal of Virology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

ABSTRACT Vaccination against the wild-type (WT) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus did not produce detectable levels of neutralizing antibodies (NAbs) BA.5 strain before it emerged. However, disease-2019 (COVID-19) severity varied highly between unvaccinated, partially vaccinated, and fully vaccinated individuals, for unknown reasons. We assessed infection risk XBB reinfection measured serum NAbs WT, BA.5, XBB.1.9.1 SARS-CoV-2 strains at varying time points in 1,373 individuals who received zero, one, two, or three WT vaccine doses. found that two to doses significantly increased NAb reduced incidence COVID-19-associated pneumonia upon compared zero one dose. Regarding reinfection, those were infected with variant exhibited a lower RNA analysis revealed differentially expressed genes dose unvaccinated groups enriched B cell activation, cytokine-cytokine receptor interaction, complement, monocyte activation functions—indicating vaccination antibody response inflammation. Our results suggest multiple antigen exposures either matched unmatched SARS-COV-2 variants, through infection, may be necessary achieve significant immune imprinting. IMPORTANCE The administration vaccines do perfectly match viral become has been impact resultant illness severity—although precise mechanism underlying this phenomenon remains unclear. clearance, as well inflammatory cytokines wild-type, variants among such strain-mismatched vaccines. Notably, ≥2 COVID-19 appeared stimulate production specific during new attenuate enhance clearance. Such regimens can also reduce reinfection. These findings important guiding development future strategies target both mismatched variants.

Язык: Английский

Effect of wild-type vaccine doses on BA.5 hybrid immunity, disease severity, and XBB reinfection risk DOI Creative Commons
D Chen, Weihong Zhang, Bin Xiao

и другие.

Journal of Virology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

ABSTRACT Vaccination against the wild-type (WT) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus did not produce detectable levels of neutralizing antibodies (NAbs) BA.5 strain before it emerged. However, disease-2019 (COVID-19) severity varied highly between unvaccinated, partially vaccinated, and fully vaccinated individuals, for unknown reasons. We assessed infection risk XBB reinfection measured serum NAbs WT, BA.5, XBB.1.9.1 SARS-CoV-2 strains at varying time points in 1,373 individuals who received zero, one, two, or three WT vaccine doses. found that two to doses significantly increased NAb reduced incidence COVID-19-associated pneumonia upon compared zero one dose. Regarding reinfection, those were infected with variant exhibited a lower RNA analysis revealed differentially expressed genes dose unvaccinated groups enriched B cell activation, cytokine-cytokine receptor interaction, complement, monocyte activation functions—indicating vaccination antibody response inflammation. Our results suggest multiple antigen exposures either matched unmatched SARS-COV-2 variants, through infection, may be necessary achieve significant immune imprinting. IMPORTANCE The administration vaccines do perfectly match viral become has been impact resultant illness severity—although precise mechanism underlying this phenomenon remains unclear. clearance, as well inflammatory cytokines wild-type, variants among such strain-mismatched vaccines. Notably, ≥2 COVID-19 appeared stimulate production specific during new attenuate enhance clearance. Such regimens can also reduce reinfection. These findings important guiding development future strategies target both mismatched variants.

Язык: Английский

Процитировано

1