Mucosal multivalent NDV-based vaccine provides cross-reactive immune responses against SARS-CoV-2 variants in animal models DOI Creative Commons
Irene González‐Domínguez,

Adam Abdeljawad,

Tsoi Ying Lai

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 17, 2025

A new generation of mucosal vaccine against the ever-evolving SARS-CoV-2 is great value to fight COVID-19. In previous studies, our groups developed a viral vector based on an avirulent Newcastle disease virus (NDV) expressing prefusion-stabilized spike protein (NDV-HXP-S). Here we characterized in vivo biodistribution and immunogenicity live NDV-HXP-S animal models. NDV showed restricted replication mice hamsters. Despite limited replication, intranasal provided protection challenge direct-contact transmission Importantly, trivalent (Wuhan, Beta, Delta) induced more cross-reactive antibody responses phylogenetically distant Omicron variant than ancestral vaccine. Furthermore, boosted systemic immunity pre-immunized with mRNA Overall, multivalent shows promise as safe, next-generation conferring broad future variants.

Язык: Английский

Mucosal multivalent NDV-based vaccine provides cross-reactive immune responses against SARS-CoV-2 variants in animal models DOI Creative Commons
Irene González‐Domínguez,

Adam Abdeljawad,

Tsoi Ying Lai

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 17, 2025

A new generation of mucosal vaccine against the ever-evolving SARS-CoV-2 is great value to fight COVID-19. In previous studies, our groups developed a viral vector based on an avirulent Newcastle disease virus (NDV) expressing prefusion-stabilized spike protein (NDV-HXP-S). Here we characterized in vivo biodistribution and immunogenicity live NDV-HXP-S animal models. NDV showed restricted replication mice hamsters. Despite limited replication, intranasal provided protection challenge direct-contact transmission Importantly, trivalent (Wuhan, Beta, Delta) induced more cross-reactive antibody responses phylogenetically distant Omicron variant than ancestral vaccine. Furthermore, boosted systemic immunity pre-immunized with mRNA Overall, multivalent shows promise as safe, next-generation conferring broad future variants.

Язык: Английский

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