Foot-and-mouth disease: genomic and proteomic structure, antigenic sites, serotype relationships, immune evasion, recent vaccine development strategies, and future perspectives DOI Creative Commons
Alyaa Elrashedy,

Mohamed Nayel,

Akram Salama

и другие.

Veterinary Research, Год журнала: 2025, Номер 56(1)

Опубликована: Апрель 7, 2025

Abstract Foot-and-mouth disease (FMD) is a highly contagious and transmissible that can have significant economic trade repercussions during outbreaks. In Egypt, despite efforts to mitigate FMD through mandatory immunization, the continues pose threat due high genetic variability quasi-species nature of virus (FMDV). Vaccines been crucial in preventing managing FMD, ongoing research focusses on developing next-generation vaccines could provide universal protection against all FMDV serotypes. This review thoroughly examines structure FMDV, including its polyprotein cleavage process roles structural non-structural proteins immune evasion. Additionally, it explores topics such as antigenic sites, specific mutations, serotype relationships from Egypt Ethiopia, well changes serotypes for vaccine development. The also addresses challenges associated with creating effective controlling particularly focusing epitope-based vaccine. Overall, this offers valuable insights researchers seeking develop strategies FMD.

Язык: Английский

Foot-and-mouth disease: genomic and proteomic structure, antigenic sites, serotype relationships, immune evasion, recent vaccine development strategies, and future perspectives DOI Creative Commons
Alyaa Elrashedy,

Mohamed Nayel,

Akram Salama

и другие.

Veterinary Research, Год журнала: 2025, Номер 56(1)

Опубликована: Апрель 7, 2025

Abstract Foot-and-mouth disease (FMD) is a highly contagious and transmissible that can have significant economic trade repercussions during outbreaks. In Egypt, despite efforts to mitigate FMD through mandatory immunization, the continues pose threat due high genetic variability quasi-species nature of virus (FMDV). Vaccines been crucial in preventing managing FMD, ongoing research focusses on developing next-generation vaccines could provide universal protection against all FMDV serotypes. This review thoroughly examines structure FMDV, including its polyprotein cleavage process roles structural non-structural proteins immune evasion. Additionally, it explores topics such as antigenic sites, specific mutations, serotype relationships from Egypt Ethiopia, well changes serotypes for vaccine development. The also addresses challenges associated with creating effective controlling particularly focusing epitope-based vaccine. Overall, this offers valuable insights researchers seeking develop strategies FMD.

Язык: Английский

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