Abstract
Anelloviruses
(AVs)
are
ubiquitous
in
humans
and
the
most
abundant
components
of
commensal
virome.
Previous
studies
on
diversity,
transmission,
persistence
AVs
mainly
focused
blood
or
transplanted
tissues
from
adults;
however,
profile
anellome
respiratory
tract
children
barely
known.
We
investigated
their
dynamics
upper
a
cohort
with
acute
infections
(ARTIs).
Different
to
that
adult,
betatorquevirus
is
genus,
followed
by
alphatorquevirus.
found
relative
abundance
was
higher
earlier
time
points,
contrast,
alphatorquevirus
later
points;
these
results
might
suggest
decreased
age
increased
childhood.
No
difference
regarding
diversity
between
single
multiple
ARTIs,
consistent
idea
AV
not
associated
certain
disease.
Most
transient,
small
proportion
(8
per
cent)
them
were
be
possibly
persistent,
ranging
1
month
as
long
56
months.
Furthermore,
individual
appeared
unique
dynamic,
replacement
existing
new
ones
common
over
different
points.
These
findings
demonstrate
may
early
colonizer
children,
unique,
which
featured
both
chronic
community
replacement.
Microbiological Research,
Год журнала:
2024,
Номер
287, С. 127857 - 127857
Опубликована: Июль 26, 2024
The
microbiota
in
the
female
genital
tract
is
an
intricate
assembly
of
diverse
aerobic,
anaerobic,
and
microaerophilic
microorganisms,
which
share
space
within
reproductive
engage
complex
interactions.
Microbiome
dysbiosis
may
disrupt
symbiotic
relationship
between
host
microorganisms
play
a
pivotal
role
pathogenesis
various
diseases,
including
its
involvement
establishment
human
papillomavirus
(HPV)-associated
cervical
cancer
(CC).
Interventions
to
restore
homeostasis
(e.g.,
probiotics)
bacterial-vector
HPV
therapeutic
vaccines
have
been
reported
be
potentially
effective
clearing
infection
ameliorating
cytological
abnormalities.
In
this
review,
we
place
emphasis
on
elucidating
alterations
cervical-vaginal
as
well
intratumoral
context
high-risk
(HR-HPV)
subsequent
progression
intraepithelial
neoplasia/CC.
Furthermore,
explore
mechanisms
by
these
microbial
communities
exert
potential
pathogenic
or
protective
effects,
modulating
inflammation
immune
responses,
affecting
HR-HPV
oncogene
expression
oncoprotein
production,
regulating
oxidative
stress
deoxyribonucleic
acid
(DNA)
damage,
inducing
metabolic
rewiring.
Lastly,
summarize
latest
evidence
trials
regarding
efficacy
probiotics,
prebiotics
probiotic-vector
vaccines.
This
review
aims
foster
deeper
understanding
infection-related
cervix
development,
further
provide
theoretical
basis
for
development
preventive
strategies
based
modulation.
Microorganisms,
Год журнала:
2025,
Номер
13(2), С. 431 - 431
Опубликована: Фев. 16, 2025
Most
research
on
the
vaginal
microbiome
has
focused
bacterial
communities
(the
bacteriome),
but
viruses,
including
eukaryotic
viruses
and
bacteriophages,
are
also
important
players
in
health
disease
states.
In
this
review,
we
will
briefly
discuss
microbiome,
delve
into
what
is
known
about
virome
its
impact
women's
health,
finish
with
novel
microbial
or
microbial-derived
therapeutics
horizon.
More
studies
needed
to
better
prevent
treat
gynecological,
reproductive,
neonatal
diseases.
Viruses,
Год журнала:
2025,
Номер
17(3), С. 334 - 334
Опубликована: Фев. 27, 2025
Torque
Teno
Virus
(TTV)
is
a
highly
prevalent
non-pathogenic
DNA
virus
whose
plasma
levels
may
be
related
to
the
host’s
immune
status.
TTV
gained
attention
about
25
years
ago,
but
its
replication
not
fully
understood,
nor
relationship
with
host's
system.
Despite
this
lack
of
knowledge,
currently
being
investigated
as
functional
biomarker
system
in
patients
immunological
damage
and
inflammatory
diseases.
Monitoring
viral
load
over
time
help
clinicians
making
therapeutic
decisions
regarding
immunosuppression
well
likelihood
infectious
complications.
This
review
summarizes
what
we
do
know
enigmatic
virus.
Healthcare,
Год журнала:
2025,
Номер
13(6), С. 599 - 599
Опубликована: Март 10, 2025
Background
and
Objectives:
Interest
in
defining
the
characteristics
of
cervicovaginal
microbiota
(CVM)
invasive
cervical
cancer
(ICC)
is
growing,
particularly
concerning
Lactobacillus
species,
as
evidence
suggests
that
these
may
differ
affected
women
potentially
interact
with
Human
Papillomavirus
(HPV)
infection.
Understanding
features
could
have
important
implications
for
disease
management.
Thus,
this
study
aims
to
systematically
review
main
available
literature
exploring
relationship
between
CVM
diversity,
profiles,
HPV
ICC;
Methods:
A
comprehensive
bibliographic
search
was
conducted
across
databases,
including
Medline,
Embase,
Scopus,
Cochrane
Database
Systematic
Reviews,
ClinicalTrials.gov,
accordance
PRISMA
guidelines.
The
included
studies
met
following
inclusion
criteria:
comparing
ICC
controls,
focusing
on
Community
State
Types
(CSTs),
microbial
diversity.
Exclusion
criteria
commentaries,
letters,
reviews,
without
control
groups.
Variables
were
analyzed
using
Kruskal–Wallis
Fisher’s
exact
tests,
statistical
significance
level
set
at
0.05.
Data
analysis
reviewed
a
blinded
manner.
Results:
total
28
published
2015
2024
criteria.
2082
patients
included,
323
(41.9%)
770
cases
testing
positive
327
(24.9%)
1312
controls
HPV.
18
specifically
examined
genotypes.
Cervical
swabs
employed
19
out
(67.9%),
while
vaginal
used
17
(60.7%).
Additionally,
two
samples
collected
via
biopsy
(7.1%),
four
utilized
lavage
(14.3%),
one
brush
sample
collection
(3.6%).
Regarding
profiling,
26
(92.9%)
16S
rRNA
analysis,
(3.6%)
whole-genome
sequencing
(WGS),
another
16s
rDNA.
10
(35.7%)
distribution
CSTs.
Five
(17.9%)
reported
profiles.
Different
levels
crispatus
iners
observed,
along
variations
Lactobacillus-dominant
Lactobacillus-depleted
communities.
22
(78.6%)
assessed
α-diversity,
(60.7%)
β-diversity;
Conclusions:
This
emphasizes
heterogeneous
association
alterations
CVM,
HPV,
development
ICC,
suggesting
need
further
research
better
understand
relationship.
These
findings
inform
new
strategies
prevention
treatment.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 3, 2025
The
human
vaginal
virome
is
an
essential
yet
understudied
component
of
the
microbiome.
Its
diversity
and
potential
contributions
to
health
disease,
particularly
vaginitis,
remain
poorly
understood.
We
conducted
metagenomic
sequencing
on
24
pooled
swab
libraries
collected
from
267
women,
including
both
healthy
individuals
those
diagnosed
with
vaginitis.
Viral
community
composition,
indices
(Shannon,
Richness,
Pielou),
phylogenetic
characteristics
were
analyzed.
Virus-host
associations
also
investigated.
DNA
viruses
dominated
virome.
Anelloviridae
Papillomaviridae
most
prevalent
eukaryotic
viruses,
while
Siphoviridae
Microviridae
leading
bacteriophages.
Compared
controls,
vaginitis
group
exhibited
significantly
reduced
alpha
greater
beta
dispersion,
indicating
altered
viral
structure.
Anelloviruses,
detected
in
groups,
showed
extensive
lineage
diversity,
frequent
recombination,
pronounced
divergence.
HPV
richness
elevated
group,
alongside
unbalanced
distribution
lineages.
Novel
phage-bacterial
identified,
suggesting
a
role
for
bacteriophages
shaping
These
findings
provide
new
insights
into
composition
structure
its
association
dysbiosis.
distinct
observed
women
highlight
relevance
communities
reproductive
health.
Future
studies
incorporating
individual-level
metatranscriptomics
are
warranted
explore
intra-host
dynamics,
assess
activity,
clarify
functional
roles
host-microbiome
interactions.
Medicina,
Год журнала:
2025,
Номер
61(5), С. 847 - 847
Опубликована: Май 5, 2025
Background
and
Objectives:
The
relationship
between
the
vaginal
microbiota,
human
papillomavirus
infection
(HPV),
cervical
precancerous
lesions
is
a
critical
area
of
research,
as
it
influences
both
progression
HPV-related
diseases
potential
treatment
strategies.
New
evidence
suggests
that
Lactobacillus
crispatus
dominance
in
microbiota
may
protect
against
HPV
persistence
speed
elimination
HPV.
This
study
aims
to
explore
composition
infection,
focusing
on
impact
these
factors
development
lesions.
Materials
Methods:
A
comprehensive
literature
review
was
conducted
using
PubMed
database,
studies
analyzed
association
context
dysplasia.
primarily
based
clinical
data
integration
women
with
low-grade
squamous
intraepithelial
(LSILs),
high-grade
(HSILs),
cancer.
Results:
Different
types
communities
(CSTs)
have
different
pathogenic
or
protective
potential.
Healthy
predominantly
exhibited
CST
I,
dominant
microorganism.
IV,
associated
increased
anaerobic
bacteria,
most
common
HSIL
cancer
patients.
Statistical
analysis
revealed
bacterial
vaginosis
(BV)
significantly
persistence,
reporting
1.8–3.4-fold
risk
(p
<
0.05)
persistent
HR-HPV
BV-positive
women.
Conclusions:
Our
can
modulate
local
immune
response,
expression
viral
oncogenes,
integrity
epithelial
barrier.
Furthermore,
certain
genes
metabolic
pathways
be
favorable
unfavorable
outcome
disease.
Analysis
could
serve
an
additional
assessment
tool,
helping
distinguish
regressing
progressive
conditions.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 15, 2024
Despite
successful
suppression
of
plasma
HIV
replication
by
antiretroviral
therapy
(ART),
some
women
living
with
(WLHIV)
can
still
experience
genital
shedding
(discordant
shedding).
Female
tract
(FGT)
microbiome
and
virome
dynamics
during
long-term
ART
in
WLHIV
are
poorly
understood
but
might
contribute
to
discordant
shedding,
as
the
known
influence
FGT
health.
To
understand
microbial
communities
over
time
usage
we
characterized
125
cervicovaginal
specimens
collected
two
years
31
Lima,
Peru.
Intrapersonal
bacterial
variation
was
higher
shedders
compared
non-shedders.
Cervicovaginal
composition
changed
time,
particularly
Specifically,
anellovirus
relative
abundance
inversely
associated
duration
CD4
counts.
Our
results
suggest
that
is
instability,
immune
recovery
influences
composition.
