Journal of Medicinal Chemistry,
Год журнала:
2020,
Номер
63(22), С. 13466 - 13513
Опубликована: Авг. 26, 2020
Toll-like
receptors
(TLRs)
are
a
class
of
proteins
that
recognize
pathogen-associated
molecular
patterns
(PAMPs)
and
damaged-associated
(DAMPs),
they
involved
in
the
regulation
innate
immune
system.
These
transmembrane
receptors,
localized
at
cellular
or
endosomal
membrane,
trigger
inflammatory
processes
through
either
myeloid
differentiation
primary
response
88
(MyD88)
TIR-domain-containing
adapter-inducing
interferon-β
(TRIF)
signaling
pathways.
In
last
decades,
extensive
research
has
been
performed
on
TLR
modulators
their
therapeutic
implication
under
several
pathological
conditions,
spanning
from
infections
to
cancer,
metabolic
disorders
neurodegeneration
autoimmune
diseases.
This
Perspective
will
highlight
recent
discoveries
this
field,
emphasizing
role
TLRs
different
diseases
effect
natural
synthetic
modulators,
it
discuss
insights
for
future
exploitation
human
health.
International Journal of Inflammation,
Год журнала:
2019,
Номер
2019, С. 1 - 15
Опубликована: Июнь 2, 2019
Experimental
work
of
the
last
two
decades
has
revealed
general
steps
wound
healing
process.
This
complex
network
been
organized
in
three
sequential
and
overlapping
steps.
The
first
step
inflammatory
phase
is
an
immediate
response
to
injury;
primary
sensory
neurons
sense
injury
send
danger
signals
brain,
stop
bleeding
start
inflammation.
following
target
phase,
led
by
peripheral
blood
mononuclear
cells,
eliminate
pathogens
clean
wound.
Once
this
completed,
resolved
homeostasis
restored.
aim
proliferative
second
repair
damage
begin
tissue
remodeling.
Fibroplasia,
reepithelialization,
angiogenesis,
nerve
are
central
actions
phase.
Lastly,
objective
final
complete
remodeling
restore
skin
integrity.
review
provides
present
day
information
regarding
status
participant
extracellular
matrix,
cytokines,
chemokines,
growth
factors,
as
well
their
interactions
with
microenvironment
during
Antioxidants,
Год журнала:
2018,
Номер
7(8), С. 98 - 98
Опубликована: Июль 24, 2018
Wound
healing
is
a
well-tuned
biological
process,
which
achieved
via
consecutive
and
overlapping
phases
including
hemostasis,
inflammatory-related
events,
cell
proliferation
tissue
remodeling.
Several
factors
can
impair
wound
such
as
oxygenation
defects,
aging,
stress
well
deleterious
health
conditions
infection,
diabetes,
alcohol
overuse,
smoking
impaired
nutritional
status.
Growing
evidence
suggests
that
reactive
oxygen
species
(ROS)
are
crucial
regulators
of
several
processes.
ROS
centrally
involved
in
all
processes
low
concentrations
generation
required
for
the
fight
against
invading
microorganisms
survival
signaling.
Excessive
production
or
detoxification
causes
oxidative
damage,
main
cause
non-healing
chronic
wounds.
In
this
context,
experimental
clinical
studies
have
revealed
antioxidant
anti-inflammatory
strategies
proven
beneficial
state.
Among
available
strategies,
treatments
using
mitochondrial-targeted
antioxidants
particular
interest.
Specifically,
peptides
elamipretide
potential
to
mitigate
mitochondrial
dysfunction
aberrant
inflammatory
response
through
activation
nucleotide-binding
oligomerization
domain
(NOD)-like
family
receptors,
pyrin
containing
3
(NLRP3)
inflammasome,
nuclear
factor-kappa
B
(NF-κB)
signaling
pathway
inhibition,
factor
(erythroid-derived
2)-like
2
(Nrf2).
Stem Cell Research & Therapy,
Год журнала:
2019,
Номер
10(1)
Опубликована: Март 29, 2019
Normal
wound
healing
is
a
dynamic
and
complex
multiple
phase
process
involving
coordinated
interactions
between
growth
factors,
cytokines,
chemokines,
various
cells.
Any
failure
in
these
phases
may
lead
wounds
to
become
chronic
have
abnormal
scar
formation.
Chronic
affect
patients'
quality
of
life,
since
they
require
repetitive
treatments
incur
considerable
medical
costs.
Thus,
much
effort
has
been
focused
on
developing
novel
therapeutic
approaches
for
treatment.
Stem-cell-based
strategies
proposed
treat
wounds.
They
shown
potential
improving
the
rate
regenerating
skin.
However,
there
are
many
challenges
using
stem
cells
skin
regeneration.
In
this
review,
we
present
some
sets
data
published
embryonic
cells,
induced
pluripotent
adult
Additionally,
will
discuss
different
angles
whereby
can
contribute
their
unique
features
show
current
drawbacks.
Frontiers in Pharmacology,
Год журнала:
2018,
Номер
9
Опубликована: Март 28, 2018
Alarming
data
about
increasing
resistance
to
conventional
antibiotics
are
reported,
while
at
the
same
time
development
of
new
is
stagnating.
Skin
and
soft
tissue
infections
(SSTIs)
mainly
caused
by
so
called
ESKAPE
pathogens
(Enterococcus
faecium,
Staphylococcus
aureus,
Klebsiella
pneumoniae,
Acinetobacter
baumannii,
Pseudomonas
aeruginosa,
Enterobacter
species)
which
belong
most
recalcitrant
bacteria
resistant
almost
all
common
antibiotics.
S.
aureus
P.
aeruginosa
frequent
isolated
from
chronic
wounds
topical
has
become
a
major
issue.
Therefore,
treatment
options
urgently
needed.
In
recent
years,
research
focused
on
synthetic
antimicrobial
peptides
(AMPs)
with
lower
toxicity
improved
activity
compared
their
endogenous
counterparts.
AMPs
appear
be
promising
therapeutic
for
SSTIs
as
they
show
broad
spectrum
activity,
low
rates
display
pivotal
immunomodulatory
well
wound
healing
promoting
activities
such
induction
cell
migration
proliferation
angiogenesis.
this
review,
we
evaluate
potential
bacterial
provide
an
overview
mechanisms
actions
that
contribute
combat
skin
improve
healing.
Bacteria
growing
in
biofilms
more
than
planktonic
counterparts
due
limited
biofilm
penetration
distinct
metabolic
physiological
functions,
often
result
chronification
wounds.
Thus,
further
discuss
feasibility
anti-biofilm
agents.
Finally,
highlight
perspectives
future
therapies
issues
remain
bring
successfully
market.
International Journal of Inflammation,
Год журнала:
2017,
Номер
2017, С. 1 - 17
Опубликована: Янв. 1, 2017
Wound
healing
is
a
complex
event
that
develops
in
three
overlapping
phases:
inflammatory,
proliferative,
and
remodeling.
These
phases
are
distinct
function
histological
characteristics.
However,
they
depend
on
the
interaction
of
cytokines,
growth
factors,
chemokines,
chemical
mediators
from
cells
to
perform
regulatory
events.
In
this
article,
we
will
review
pathway
skin
cascade,
relating
major
inflammatory
mediators,
cellular
molecular,
as
well
demonstrating
local
systemic
factors
interfere
disorders
associated
with
tissue
repair
deficiency.
Finally,
discuss
current
therapeutic
interventions
wounds
treatment,
alternative
therapies
used
promising
results
development
new
products
potential.
Physiological Reviews,
Год журнала:
2018,
Номер
98(2), С. 727 - 780
Опубликована: Фев. 21, 2018
When
cells
undergo
necrotic
cell
death
in
either
physiological
or
pathophysiological
settings
vivo,
they
release
highly
immunogenic
intracellular
molecules
and
organelles
into
the
interstitium
thereby
represent
strongest
known
trigger
of
immune
system.
With
our
increasing
understanding
necrosis
as
a
regulated
genetically
determined
process
(RN,
necrosis),
necroinflammation
can
be
pharmacologically
prevented.
This
review
discusses
current
knowledge
about
signaling
pathways
origin
necroinflammation.
Multiple
RN
such
necroptosis,
ferroptosis,
pyroptosis
have
been
evolutionary
conserved
most
likely
because
their
differences
immunogenicity.
As
consequence
necrosis,
however,
all
damage
associated
molecular
patterns
(DAMPs)
that
extensively
investigated
over
last
two
decades.
Analysis
allows
characterizing
specific
signatures
for
each
particular
pathway
death.
While
RN-pathways
share
DAMPs
general,
them
actively
regulate
system
by
additional
expression
and/or
maturation
pro-
anti-inflammatory
cytokines/chemokines.
In
addition,
demonstrated
to
modulate
regeneration.
For
purpose
better
necroinflammation,
we
introduce
novel
classification
this
help
detect
relative
contribution
RN-pathway
certain
conditions.
