Eosinophilic Esophagitis and Cow’s Milk: Mechanisms, Challenges, and Treatment Perspectives DOI Open Access
Giulio Dinardo, Alessandro Fiocchi, Maria Cristina Artesani

и другие.

Nutrients, Год журнала: 2025, Номер 17(2), С. 265 - 265

Опубликована: Янв. 12, 2025

Eosinophilic esophagitis is a chronic, antigen-driven, immune-mediated disease characterized by esophageal dysfunction and significant eosinophilic infiltration. Its rising incidence prevalence over recent decades reflect both increased clinical awareness the influence of environmental factors such as dietary patterns allergen exposure. Among food allergens, cow’s milk proteins are most commonly implicated triggers, contributing to inflammation through complex immunological pathways involving IgE-mediated non-IgE-mediated mechanisms. Dietary elimination has been shown induce histologic remission in 60% pediatric patients, underscoring its pivotal role management. Despite these promising results, challenges persist, including variability individual responses, burden adherence restrictive diets, gaps understanding molecular mechanisms driving milk-induced inflammation. This review examines relationship between milk, focusing on pathogenesis management, offering insights into therapeutic implications. Understanding interplay particularly may inform development targeted interventions improve outcomes for affected patients.

Язык: Английский

Eosinophilic Esophagitis and Cow’s Milk: Mechanisms, Challenges, and Treatment Perspectives DOI Open Access
Giulio Dinardo, Alessandro Fiocchi, Maria Cristina Artesani

и другие.

Nutrients, Год журнала: 2025, Номер 17(2), С. 265 - 265

Опубликована: Янв. 12, 2025

Eosinophilic esophagitis is a chronic, antigen-driven, immune-mediated disease characterized by esophageal dysfunction and significant eosinophilic infiltration. Its rising incidence prevalence over recent decades reflect both increased clinical awareness the influence of environmental factors such as dietary patterns allergen exposure. Among food allergens, cow’s milk proteins are most commonly implicated triggers, contributing to inflammation through complex immunological pathways involving IgE-mediated non-IgE-mediated mechanisms. Dietary elimination has been shown induce histologic remission in 60% pediatric patients, underscoring its pivotal role management. Despite these promising results, challenges persist, including variability individual responses, burden adherence restrictive diets, gaps understanding molecular mechanisms driving milk-induced inflammation. This review examines relationship between milk, focusing on pathogenesis management, offering insights into therapeutic implications. Understanding interplay particularly may inform development targeted interventions improve outcomes for affected patients.

Язык: Английский

Процитировано

1