Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 8, 2024
Abstract
Objective:
This
study
aimed
to
investigate
the
causal
relationship
between
inflammatory
cytokines
and
oral
cavity
cancer
risk
using
Mendelian
randomization
analysis.
Methods:
Two-sample
was
conducted
summary-level
genome-wide
association
data
on
41
in
Europeans.
Single
nucleotide
polymorphisms
associated
with
(p<5x10-6)
were
selected
as
instrumental
variables,
excluding
those
linkage
disequilibrium.
Inverse-variance
weighted
analysis
used
primary
method,
supplemented
by
MR
Egger,
median,
simple
mode
methods.
Sensitivity
analyses
included
heterogeneity,
horizontal
pleiotropy,
leave-one-out,
funnel
plot
assessments.
Multivariable
adjusted
for
smoking,
alcohol,
periodontitis
malnutrition
performed.
Results:
In
univariate
analysis,
increased
beta-nerve
growth
factor
(OR:
1.53,
95%
CI:
1.06–2.20),
decreased
macrophage
colony
stimulating
0.87,
0.78–0.98)
interleukin-18
0.80,
0.65–0.98)
causally
higher
risk.
multivariable
effects
of
1.63,
1.24–2.13)
,macrophage
factor(OR:0.87,
CI:0.75–1.00)and
0.82,
0.67–0.99)
remained
significant
after
adjusting
exposures.
No
reverse
causation
found.
Conclusions:
provides
evidence
along
risk,
independent
known
factors.
These
may
represent
etiologic
targets
prevention.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 30, 2024
Acute
myeloid
leukemia
(AML)
is
a
hostile
hematological
malignancy
under
great
danger
of
relapse
and
poor
long-term
survival
rates,
despite
recent
therapeutic
advancements.
To
deal
with
this
unfulfilled
clinical
necessity,
innovative
cell-based
immunotherapies
have
surfaced
as
promising
approaches
to
improve
anti-tumor
immunity
enhance
patient
outcomes.
In
comprehensive
review,
we
provide
detailed
examination
the
latest
developments
in
for
AML,
including
chimeric
antigen
receptor
(CAR)
T-cell
therapy,
(TCR)-engineered
natural
killer
(NK)
therapies.
We
critically
evaluate
unique
mechanisms
action,
current
challenges,
evolving
strategies
efficacy
safety
these
modalities.
The
review
emphasizes
how
cutting-edge
immune-based
are
overcoming
inherent
complexities
heterogeneity
AML.
discuss
identification
optimal
target
antigens,
importance
mitigating
on-target/off-tumor
toxicity,
need
persistence
functionality
engineered
immune
effector
cells.
All
things
considered,
offers
thorough
overview
rapidly
field
immunotherapy
underscoring
significant
progress
made
ongoing
efforts
translate
into
more
effective
durable
treatments
devastating
disease.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15230 - 15230
Опубликована: Окт. 16, 2023
RNA-based
therapy
has
been
an
expanding
area
of
clinical
research
since
the
COVID-19
outbreak.
Often,
its
comparison
made
to
DNA-based
gene
therapy,
such
as
adeno-associated
virus-
and
lentivirus-mediated
therapy.
These
therapies
show
persistent
expression,
with
maximized
therapeutic
efficacy.
However,
accumulating
data
indicate
that
proper
control
expression
is
occasionally
required.
For
example,
in
cancer
immunotherapy,
cytokine
response
syndrome
detrimental
for
host
animals,
while
excess
activation
immune
system
induces
supraphysiological
cytokines.
seems
be
a
rather
mild
it
room
fit
unmet
medical
needs,
whereas
current
unclear
issues.
This
review
focused
on
hematopoietic
disorders,
inherited
which
have
received
attention
possible
applications.
Malignant
neoplasms
arising
from
the
gastrointestinal
(GI)
tract
are
among
most
common
cancer
types
with
a
high
mortality
rate.
Despite
advances
in
treatment
small
subgroup
harboring
targetable
mutations,
outcome
remains
poor,
accounting
for
one
three
cancer-related
deaths
observed
globally.
As
promising
therapeutic
option
various
tumor
types,
immunotherapy
immune
checkpoint
inhibitors
has
also
been
evaluated
GI
cancer,
albeit
limited
efficacy
except
expressing
microsatellite
instability.
In
quest
more
effective
options,
energetic
efforts
have
placed
to
evaluate
role
of
several
approaches
comprising
vaccines,
adoptive
cell
therapies
and
inhibitors.
this
review,
we
report
our
experience
personalized
dendritic
vaccine
cytokine-induced
killer
therapy
patients
cancers
summarize
current
clinical
data
on
combined
strategies.
Vaccines,
Год журнала:
2023,
Номер
11(10), С. 1545 - 1545
Опубликована: Сен. 29, 2023
Malignant
neoplasms
arising
from
the
gastrointestinal
(GI)
tract
are
among
most
common
types
of
cancer
with
high
mortality
rates.
Despite
advances
in
treatment
a
small
subgroup
harboring
targetable
mutations,
outcome
remains
poor,
accounting
for
one
three
cancer-related
deaths
observed
globally.
As
promising
therapeutic
option
various
tumor
types,
immunotherapy
immune
checkpoint
inhibitors
has
also
been
evaluated
GI
cancer,
albeit
limited
efficacy
except
expressing
microsatellite
instability.
In
quest
more
effective
options,
energetic
efforts
have
placed
to
evaluate
role
several
approaches
comprising
vaccines,
adoptive
cell
therapies
and
inhibitors.
this
review,
we
report
our
experience
personalized
dendritic
vaccine
cytokine-induced
killer
therapy
patients
cancers
summarize
current
clinical
data
on
combined
strategies.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 8, 2024
Abstract
Objective:
This
study
aimed
to
investigate
the
causal
relationship
between
inflammatory
cytokines
and
oral
cavity
cancer
risk
using
Mendelian
randomization
analysis.
Methods:
Two-sample
was
conducted
summary-level
genome-wide
association
data
on
41
in
Europeans.
Single
nucleotide
polymorphisms
associated
with
(p<5x10-6)
were
selected
as
instrumental
variables,
excluding
those
linkage
disequilibrium.
Inverse-variance
weighted
analysis
used
primary
method,
supplemented
by
MR
Egger,
median,
simple
mode
methods.
Sensitivity
analyses
included
heterogeneity,
horizontal
pleiotropy,
leave-one-out,
funnel
plot
assessments.
Multivariable
adjusted
for
smoking,
alcohol,
periodontitis
malnutrition
performed.
Results:
In
univariate
analysis,
increased
beta-nerve
growth
factor
(OR:
1.53,
95%
CI:
1.06–2.20),
decreased
macrophage
colony
stimulating
0.87,
0.78–0.98)
interleukin-18
0.80,
0.65–0.98)
causally
higher
risk.
multivariable
effects
of
1.63,
1.24–2.13)
,macrophage
factor(OR:0.87,
CI:0.75–1.00)and
0.82,
0.67–0.99)
remained
significant
after
adjusting
exposures.
No
reverse
causation
found.
Conclusions:
provides
evidence
along
risk,
independent
known
factors.
These
may
represent
etiologic
targets
prevention.
