Cell Reports Medicine, Год журнала: 2023, Номер 4(11), С. 101293 - 101293
Опубликована: Ноя. 1, 2023
In this issue, Pang and colleagues
Язык: Английский
Cell Proliferation, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
ABSTRACT Due to the lack of effective therapeutic approach, glioblastoma (GBM) remains one most malignant brain tumour. By in vitro investigations on primary GBM stem cells, we highlighted underlying mechanisms drug resistance alkylating agents, DNA damage responses. Here, flow cytometric analysis and viability repopulation assays were used assess long‐term cytotoxic effect induced by administration a fourth‐generation platinum prodrug, ( OC ‐6‐44)‐acetatodiamminedichlorido(2‐(2‐propynyl)octanoato) platinum(IV) named Pt(IV)Ac‐POA, comparison widely Cisplatin. The immunofluorescence studies revealed changing pathways involved response two chemotherapies, suggesting particular role Poly (ADP‐Ribose) polymerases onset Cisplatin‐induced cytotoxicity. Thus, this research provides proof concept for how use prodrug which allows co‐administration Cisplatin an Histone DeACetylase inhibitors, could suppress repair mechanisms, novel approach treatment.
Язык: Английский
Процитировано
0
Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер 208, С. 104649 - 104649
Опубликована: Фев. 6, 2025
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2025, Номер 14(3), С. 258 - 258
Опубликована: Фев. 24, 2025
Oxidative stress, which is characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, has critical roles in the initiation, progression, treatment of gastric cancer. On one hand, excessive ROS accumulation induces oxidative damage cancer cell death. other moderate levels cause genetic mutations dysregulation signaling pathways to promote proliferation, inflammation, angiogenesis, metastasis Notably, emerging evidence revealed that also mediate post-translational modifications (oxPTMs) redox-sensitive proteins, can directly affect protein functions regulate redox cells. Therefore, elucidating regulatory mechanisms stress holds great promise identify novel therapeutic targets or redox-targeting strategies. This review will summarize regulating hallmarks highlight ROS-mediated oxPTMs In addition, we discuss strategies targeting for cancer, with emphasis on use bioactive natural products nanomaterials.
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Март 4, 2025
Platinum (Pt)-based chemotherapeutic agents, known for their potent cytotoxicity, are extensively used in clinical oncology. However, therapeutic efficacy is severely limited by a variety of factors, particularly the hypoxic tumor microenvironment (TME), which not only impedes effective drug delivery but also triggers immune suppression, further diminishing antitumor effects Pt drugs. In response to these challenges, we have developed biotin receptor (BR)-targeting oxaliplatin (OXA)-based PtIV prodrug, named Lipo-OPtIV-BT, could encapsulate hemoglobin (Hb) as an oxygen carrier, forming PtIV-loaded lipid nanoparticles (Hb@BTOPtIV). The design Hb@BTOPtIV aims address dual issues poor and suppression effectively increasing local tension TME. Notably, our findings demonstrate that cytotoxic BR-targeting prodrug increased levels synergistically reverse microenvironment, leading improved efficacy. We observed significantly biodistribution drug, enabling it preferentially accumulate regions. Importantly, enhanced oxygenation within TME plays critical role reshaping landscape tumor, promoting more favorable environment chemotherapy. This reversal evidenced infiltration T cells reduced regulatory (Tregs) tumor. These highlight promising potential using amphiphiles improve accumulation at sites counteract immunosuppression induced hypoxia.
Язык: Английский
Процитировано
0
Trends in cancer, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Journal of Neuro-Oncology, Год журнала: 2025, Номер unknown
Опубликована: Март 13, 2025
Язык: Английский
Процитировано
0
Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 4177 - 4193
Опубликована: Март 1, 2025
Combining radiotherapy (RT) with immunotherapy for head and neck squamous cell carcinoma (HNSCC) has limited effectiveness due to the DNA damage repair (DDR) pathway activated by ionizing radiation. DNA-PK, encoded PRKDC gene, plays a key role in this repair. The potential improvement of radioimmunotherapy inhibiting DDR is still unclear. different treatments on tumor growth survival was tested using C3H/HeN mouse model. Flow cytometry analyzed treatment-induced immunophenotypic changes. In vitro, Western blot PCR confirmed impact combining RT cGAS-STING after DNA-PKcs dysfunction. combination DNA-PK inhibitor (NU7441), radiation therapy, PD-1 checkpoint showed improved antitumor effects extended mice. Adding NU7441 into regimen increased CD8+ T infiltration. alterations or dysfunction IR-induced breaks, activating boosting anti-tumor immune response. These findings suggest that targeting may represent promising therapeutic strategy biomarker improve efficacy HNSCC.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Март 28, 2025
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, characterized by rapid proliferation, extensive infiltration, significant intratumoral heterogeneity. Despite advancements conventional treatments, including surgery, radiotherapy, chemotherapy, prognosis for GBM patients remains poor, with a median survival of approximately 15 months. Immunotherapy has emerged as promising alternative; however, unique biological immunological features, its immunosuppressive microenvironment (TME) low mutational burden, render it resistant to many immunotherapeutic strategies. This review explores key challenges immunotherapy, focusing on immune evasion mechanisms, blood-brain barrier (BBB), TME. Immune checkpoint inhibitors CAR-T cells have shown promise preclinical models but limited clinical success due antigen heterogeneity, cell exhaustion, impaired trafficking across BBB. Emerging strategies, dual-targeting cells, engineered secreting therapeutic molecules, advanced delivery systems overcome BBB, show potential enhancing treatment efficacy. Addressing these crucial improving immunotherapy outcomes.
Язык: Английский
Процитировано
0
Experimental Biology and Medicine, Год журнала: 2024, Номер 249
Опубликована: Июль 22, 2024
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, having become a global public health problem, so pathophysiological mechanisms and therapeutic strategies CVDs need further study. Legumain is powerful enzyme that widely distributed in mammals plays an important role variety biological processes. Recent research suggests legumain associated with occurrence progression CVDs. In this review, we provide comprehensive overview pathogenesis The CVDs, such as carotid atherosclerosis, pulmonary hypertension, coronary artery disease, peripheral arterial aortic aneurysms dissection, discussed. potential applications biomarker these also explored. By understanding aim to support new prevent or treat diseases.
Язык: Английский
Процитировано
1
International Immunopharmacology, Год журнала: 2024, Номер 147, С. 113856 - 113856
Опубликована: Дек. 30, 2024
The tumor microenvironment (TME), with hallmark features of hypoxia and immunosuppression, plays a crucial role in the progression various solid tumors. However, intricate interplay between formation immune glioma remains incompletely understood. In present study, we initially identified genes associated through GSEA IMMPORT database analysis. We subsequently hypoxia- immune-related prognosis further cross-analysis multidatabase integrated HSPA5 was ultimately as potential target gene related to hypoxic glioma. Furthermore, conducted MTT, colony formation, EdU, migration invasion assays intracranial orthotopic model analysis evaluate impact interfering expression on microenvironments found that is highly expressed cells tissues poor prognosis. Further investigation revealed promotes malignant biological characteristics reshaping Immunosuppressive phenotype tumor-associated macrophages (TAMs) upregulation HIF-1α/HSPA5 axis. Silencing alleviated tolerance induced polarization TAMs toward M1 phenotype. could exhibit tumor-suppressive effect. These observations suggest by inducing TAMs. Therefore, targeting may be novel therapeutic strategy for
Язык: Английский
Процитировано
1