From Teeth to Body: The Complex Role of Streptococcus mutans in Systemic Diseases

Molecular Oral Microbiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

ABSTRACT Streptococcus mutans , the principal pathogen associated with dental caries, impacts individuals across all age groups and geographic regions. Beyond its role in compromising oral health, a growing body of research has established link between S. various systemic diseases, including immunoglobulin A nephropathy (IgAN), nonalcoholic steatohepatitis (NASH), infective endocarditis (IE), ulcerative colitis (UC), cerebral hemorrhage, tumors. The pathogenic mechanisms frequently involve collagen‐binding proteins (CBPs) protein antigens (PA) present on bacterial surface. These components facilitate intricate interactions host immune system, thereby potentially contributing to pathological processes. Specifically, CBP is implicated deposition IgA complement component C3, which exhibits characteristics reminiscent IgAN‐like lesions through animal models, recent clinical studies suggest potential involvement IgAN. In addition, binds C1q, effectively inhibiting classical activation pathway system. promotes induction cells produce interferon‐gamma (IFN‐γ). Furthermore, leads direct inhibitory effects platelets matrix metalloproteinase‐9 (MMP‐9) at sites vascular injury. Moreover, PA enhances ability invade hepatic tissue. Through utilization PAc, excessively produces kynurenine (KYNA), development progression squamous cell carcinoma (OSCC). This article synthesizes latest advancements understanding conditions humans, expanding our perspective beyond traditional focus caries.

Язык: Английский

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Precision Dietary Intervention: Gut Microbiome and Meta-metabolome as Functional Readouts

Phenomics, Год журнала: 2025, Номер 5(1), С. 23 - 50

Опубликована: Фев. 1, 2025

Язык: Английский

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Multi-omics Reveal the Effects and Regulatory Mechanism of Dietary Echinocystic Acid Supplementation on Abdominal Fat and Liver Steatosis in Broiler Chickens

Poultry Science, Год журнала: 2025, Номер 104(4), С. 104981 - 104981

Опубликована: Март 5, 2025

The accumulation of abdominal fat and the metabolic dysfunction-associated fatty liver disease (MAFLD) are prevalent problems in poultry industry, seriously compromise broiler health reduce economic benefits. Echinocystic acid (EA), a natural product with anti-inflammatory antioxidant effects, has been demonstrated to deposition improve intestinal inflammation mice. However, it not reported research. In this study, we employed chicken hepatocytes (Leghorn male hepatoma cells, LMHs) construct an oleic palmitic (OA/PA)-induced MAFLD model vitro 60 K90 chickens were induced by high-fat diet (HFD) examine impact EA on liver-lipid metabolism deposition. Moreover, metabolomic analysis, 16S rDNA gene sequencing, transcriptomic profiling performed determine mechanism EA. results showed that (10 μM) significantly reduced triglyceride (TG) total cholesterol (TC) levels vitro. without affecting growth performance. decreased TC, TG, low-density lipoprotein-cholesterol (LDL-C) levels, increased high-density (HDL-C) blood. Additionally, supplementation altered composition microbiota, particularly decreasing ratio Firmicutes Bacteroidetes. Furthermore, metabolomics analysis revealed abundance metabolites related arginine mitochondrial oxidation pathways, these predicted be positively correlated gut genera enriched also expression patterns genes lipid inflammation, CYP7A1, CYP7B1, CYP3A5, ACAT, which PPAR signaling pathway steroid hormone metabolism. correlation there was close between differential metabolites, profiles. Collectively, indicated may alleviate regulating modulating microbiota. candidate feed additive prevent industry.

Язык: Английский

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Differential effects of ellagic acid on non-alcoholic fatty liver disease in mice: grouped by urolithin A-producing capacity

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Ellagic acid (EA) exhibits protective effects on non-alcoholic fatty liver disease (NAFLD). However, the ability to produce urolithins and health benefits associated with EA consumption differ considerably among individuals. Therefore, different of high-fat high-fructose diet (HFFD)-induced NAFLD, considering variability in urolithin-producing ability, were explored. Our results showed that could effectively reduce body weight, lipid accumulation insulin resistance, improve oxidative stress inflammation NAFLD mice. The metabolomics analysis indicated metabolism disorder induced by HFFD was obviously improved mainly through regulation unsaturated biosynthesis amino metabolism. In particular, improvement effect mice high urolithin A production better than their low counterparts. Moreover, treatment reshaped gut microbiota imbalance caused HFFD. Specifically, compared model group, lower abundances Faecalibaculum (by 95.11%), Ruminococcus_torques_group 208.14%), Clostridium_sensu_stricto_1 449.37%), Ileibacterium 172.64%), while higher Verrucomicrobia Akkermansia 425.0%) observed high-UroA-producing group (p < 0.05). This study provided new insights into EA's anti-NAFLD effectiveness suggested response capacity greatly determined performance alleviating development NAFLD.

Язык: Английский

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Structure characteristics and fermentation properties of konjac oligosaccharides from konjac peel prepared by one-step fermentation with Bacillus Licheniformis BJ2022

Food Chemistry, Год журнала: 2025, Номер unknown, С. 144332 - 144332

Опубликована: Апрель 1, 2025

Язык: Английский

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Gut microbiota in patients with metabolic, dysfunction-associated steatotic liver disease

Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Purpose of review Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent condition that can progress to fibrosis, steatohepatitis, and hepatocellular carcinoma. This examines recent advances concerning the role gut microbiota in MASLD microbiota-focused interventions positively impact outcome. Recent findings Dysbiotic compromised barrier facilitate translocation microbial-associated molecular patterns harmful metabolites into portal circulation liver, where they exacerbate inflammatory fibrogenic processes. Conversely, other bacterial have protective effects liver. Therefore, homeostasis essential for maintaining health. Summary Levels including ethanol, NH 3 , trimethylamine-L-oxide, 2-oleylglycerol, litocholic acid are often increased patients with MASLD. short-chain fatty acids, indole derivatives, histidine, acids taurodeoxycholic, 3-succinylcholic, hyodeoxycholic decreased. The main aim current interventions/treatments reduce increase beneficial ones. These include drugs (pemafibrate, metformin, obeticholic acid), natural compounds (silymarin, lupeol, dietary fiber, peptides), exogenous bacteria (probiotics, symbionts), special diets (Mediterranean diet, time-restricted feeding), as well transplantation, phage therapy. Most improve permeability, inflammation, fibrosis through regulation, promising alternatives MASLFD management. However, most results come from animal studies, while clinical trials lacking. Further research therefore needed this area.

Язык: Английский

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Gut microbiome dysbiosis as a potential biomarker for liver metabolic disorders in in neonatal hemolytic jaundice

BMC Pediatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 29, 2025

Язык: Английский

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Gut microbial enzymes and metabolic dysfunction-associated steatohepatitis: Function, mechanism, and therapeutic prospects

Cell Host & Microbe, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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Branched-chain amino acids induce hyperammonemia via gut-liver axis-mediated ammonia overproduction in laying hens

Animal nutrition, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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Gut microbiota–NLRP3 inflammasome crosstalk in metabolic dysfunction-associated steatotic liver disease

Clinics and Research in Hepatology and Gastroenterology, Год журнала: 2024, Номер 48(8), С. 102458 - 102458

Опубликована: Сен. 2, 2024

Nonalcoholic fatty liver disease (NAFLD) is a chronic associated with metabolic dysfunction, ranging from hepatic steatosis or without mild inflammation to nonalcoholic steatohepatitis, which can rapidly progress fibrosis and even cancer. In 2023, after several rounds of Delphi surveys, new consensus recommended renaming NAFLD as dysfunction-associated steatotic (MASLD). Ninety-nine percent patients meet the MASLD criteria related cardiovascular risk factors under "multiple parallel hits" lipotoxicity, insulin resistance (IR), proinflammatory diet, an intestinal microbiota disorder, previous research on remains valid. The NLRP3 inflammasome, well-known member pattern recognition receptor (PRR) family, be activated by danger signals transmitted pathogen-associated molecular patterns (PAMPs) damage-associated (DAMPs), well cytokines involved in immune inflammatory responses. activation inflammasome pathway triggers production IL-1β IL-18. MASLD, while changes composition metabolites occur, disrupted also generate IL-18 damaging barrier, negatively regulating gut–liver axis, further aggravating MASLD. Therefore, modulating gut–microbiota–liver axis through may emerge novel therapeutic approach for patients. this article, we review evidence regarding functions their interactions disease.

Язык: Английский

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