Identification of bile acids in snake bile by hydrogen/deuterium exchange mass spectrometry and quantitative structure-retention relationship analysis DOI
Yinyu Wei,

Chenyue Zhu,

Xinyuan Ye

и другие.

Journal of Chromatography A, Год журнала: 2024, Номер 1736, С. 465384 - 465384

Опубликована: Сен. 17, 2024

Язык: Английский

How bile acids and the microbiota interact to shape host immunity DOI
Michael H. Lee, Sean‐Paul Nuccio, Ipsita Mohanty

и другие.

Nature reviews. Immunology, Год журнала: 2024, Номер 24(11), С. 798 - 809

Опубликована: Июль 15, 2024

Язык: Английский

Процитировано

30
Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut DOI Creative Commons
Huimin Ye, Sabrina Borusak,

Claudia Eberl

и другие.

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Сен. 18, 2023

Taurine-respiring gut bacteria produce H

Язык: Английский

Процитировано

14
Applications of Metabolomics and Lipidomics in the Neonatal Intensive Care Unit DOI
Jonathan Reiss, Samson Mataraso, Lindsay F. Holzapfel

и другие.

NeoReviews, Год журнала: 2025, Номер 26(2), С. e100 - e114

Опубликована: Фев. 1, 2025

The metabolome and lipidome comprise the thousands of molecular compounds in an organism. Molecular consist upstream metabolic components intracellular reactions or byproducts cellular pathways. biochemical perturbations are associated with disorders newborns infants. diagnosis inborn errors metabolism has relied on targeted metabolomics for several decades. Newer approaches offer potential to identify novel biomarkers common diseases newborn infant. They may also elucidate predictive diagnostic measures a variety health trajectories. Here, we review relevance highlight challenges opportunities future investigations.

Язык: Английский

Процитировано

0
MS/MS Mass Spectrometry Filtering Tree for Bile Acid Isomer Annotation DOI Creative Commons
Ipsita Mohanty, Shipei Xing, Vanessa Castillo

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Abstract Bile acids are essential steroids regulating immunity, nutrient absorption, insulin, appetite, and body temperature. Their structural diversity is vast, but due to spectral similarities, MS/MS matching often fails resolve isomers. This study introduces a proof-of-concept workflow using mass spectrometry query language filtering tree that distinguishes isomeric bile in untargeted LC-MS/MS data. Its application revealed deoxycholyl-2-aminophenol amidate linked whole grain consumption.

Язык: Английский

Процитировано

0
Role of the Gut-Brain Axis in Severe Traumatic Brain Injury: Insights from Experimental Models and Clinical Studies DOI Creative Commons
Venencia Albert, Arulselvi Subramanian, Deepak Agrawal

и другие.

Indian Journal of Neurotrauma, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Abstract Introduction Traumatic brain injury (TBI) induces systemic alterations, including gut microbiome dysbiosis, increased intestinal permeability, and neuroinflammatory responses. This review explores the bidirectional gut-brain interactions, focusing on inflammation, potential therapeutic interventions. Materials Methods A comprehensive of preclinical human studies was conducted to assess microbiota changes following TBI. Key findings microbial shifts, markers, strategies were analyzed. Results Experimental animal models demonstrate that TBI leads loss short-chain fatty acid-producing bacteria, bacterial translocation due impaired barrier function. These alterations exacerbate cascades, microglial activation, cytokine release, oxidative stress. Dysbiosis-induced metabolic shifts influence tryptophan metabolism kynurenine pathway contributing excitotoxicity neurodegeneration. Human reveal persistent imbalances in severe patients, correlating with inflammation prolonged recovery. Conclusion Despite growing evidence linking neuroinflammation secondary injury, challenges remain translating clinical applications. Heterogeneity experimental models, variability assessment techniques, gaps mechanistic understanding hinder standardization. Emerging microbiome-targeted therapies, probiotics, offer promising avenues for modulating improving neurological recovery post-TBI. Further research is needed establish causal relationships, optimize strategies, evaluate long-term outcomes.

Язык: Английский

Процитировано

0
Cholestasis in alcohol-associated liver disease DOI Creative Commons
Shengmin Yan, Xiao‐Ming Yin

American Journal Of Pathology, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Cross-organ metabolite production and consumption in healthy and atherogenic conditions DOI
Hosung Bae, Sunhee Jung, Johnny Le

и другие.

Cell, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Gut microbiota genome features associated with brain injury in extremely premature infants DOI Creative Commons

David Seki,

Rasmus Hansen Kirkegaard, Jay Osvatic

и другие.

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Окт. 7, 2024

Severe brain damage is common among premature infants, and the gut microbiota has been implicated in its pathology. Although order of colonizing bacteria well described, mechanisms underlying aberrant assembly remain elusive. Here, we employed long-read nanopore sequencing to assess abundances microbial species their functional genomic potential stool samples from a cohort 30 extremely infants. We identify several key traits significantly associated with severe damage, such as for nitrate respiration iron scavenging. Members

Язык: Английский

Процитировано

2
Identification of bile acids in snake bile by hydrogen/deuterium exchange mass spectrometry and quantitative structure-retention relationship analysis DOI
Yinyu Wei,

Chenyue Zhu,

Xinyuan Ye

и другие.

Journal of Chromatography A, Год журнала: 2024, Номер 1736, С. 465384 - 465384

Опубликована: Сен. 17, 2024

Язык: Английский

Процитировано

0