Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 24, 2024
Background
The
occurrence
of
immune-related
adverse
events
(irAEs)
seemed
to
be
associated
with
better
outcomes
in
advanced
gastric
cancer
(AGC)
patients.
However,
research
focusing
on
the
impact
single-organ
irAE
(uni-irAE)
or
multi-organ
irAEs
(multi-irAEs)
AGC
outcome
is
relatively
limited.
In
this
study,
we
investigated
individually
different
survival
as
well
co-occurrence
patterns
multi-irAEs.
Methods
uni-irAE,
multi-irAEs,
and
non-irAE
were
identified
based
National
Comprehensive
Cancer
Network
(NCCN)
guidelines.
ICI
efficacy
for
disease
control
rate
(DCR)
objective
response
(ORR)
was
assessed
Response
Evaluation
Criteria
Solid
Tumors
(RECIST)
Version
1.1.
association
progression-free
(PFS)
overall
(OS)
analyzed
using
Kaplan–Meier
method
Cox
regression
model.
We
also
performed
pairwise
correlation
analysis
identify
irAEs.
Results
A
total
288
patients
including
175
non-irAE,
73
40
multi-irAE
evaluated
their
outcome.
displayed
higher
DCR
(78.8%
vs.
67.4%,
p
=0.037)
when
compared
those
patients,
both
uni-irAE
(82.2%
=0.019)
(72.5%
=0.534)
showed
than
that
multivariate
analyses
revealed
multi-irAEs
an
independent
risk
factor
PFS
(hazard
ratio
[HR]
0.63,
95%
confidence
interval
[CI]
0.41~0.96,
=0.031)
OS
(HR
0.47,
CI
0.29~0.76,
=0.002),
whereas
not
obtained.
thyroid,
adrenal
gland,
heart,
skin,
lung
exhibited
a
high
organ-specific
experiencing
skin
had
favorable
without
these
Conclusion
Multi-irAEs
some
can
used
predictive
indicators
treatment
are
often
accompanied
by
occurrence.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 27, 2024
Abstract
Alterations
in
the
gut
microbiota
have
been
linked
to
hypertension,
with
role
of
archaea,
despite
being
stable
constituents,
remaining
largely
unexplored.
Shotgun
metagenomic
analyses
fecal
samples
were
performed
on
341
participants
from
3
cohorts:
discovery
cohort
(88
individuals),
validation
1
(175
and
2
(78
individuals).
Principal
Coordinates
Analysis
(PCoA)
based
Bray-Curtis
distances
revealed
significant
alterations
composition
enteric
archaea
between
control
individuals
hypertensive
patients
(P
<
0.05).
Hypertensive
groups
showed
reduced
abundances
halophilic
(Halorhabdus,
Halovivax,
Halorubrum_lipolyticum)
methanogenic
(Methanomassiliicoccus
Candidatus_Methanomassiliicoccus_intestinalis).
Eleven
species,
depleted
patients,
distinguished
them
individuals,
areas
under
receiver
operating
characteristic
curve
0.85,
0.79,
0.91
discovery,
1,
2,
respectively.
Significant
correlations
observed
these
clinical
data
across
cohorts.
Additionally,
a
positive
correlation
richness
bacteria
suggests
close
cross-kingdom
synergy
within
microbiome.
This
study
highlights
shifts
archaeal
populations
underscoring
potential
biomarkers
hypertension
diagnosis
suggesting
avenues
for
future
therapeutic
research.
Bone Reports,
Год журнала:
2024,
Номер
23, С. 101809 - 101809
Опубликована: Окт. 11, 2024
Emerging
insights
in
osteoimmunology
have
enabled
researchers
to
explore
depth
the
role
of
immune
modulation
regulating
bone
health.
Bone
is
one
common
sites
metastasis
notably
case
breast
cancer,
prostate
cancer
and
several
other
types.
High
calcium
ion
concentration
presence
factors
within
mineralized
matrix
including
TGF-β,
BMP
etc.,
aid
tumor
growth
proliferation.
Accumulating
evidence
has
substantiated
gut-microbiota
(GM)
tumorigenesis,
further
providing
a
strong
impetus
for
growing
"immune-cancer-gut
microbiota"
relationship.
Recent
advancements
research
highlight
importance
intra-tumor
microbiota
conjunction
with
GM
metastasis.
Intratumoral
owing
their
ability
cause
genetic
instability,
mutations,
epigenetic
modifications
microenvironment,
been
recognized
affect
cell
physiology.
The
host
system
crosstalk
shapes
innate
adaptive
arms
system,
which
key
player
progression.
In
this
review,
we
aim
decipher
microorganisms
mediating
by
shedding
light
on
immuno-onco-microbiome
(IOM)
axis.
We
discussed
feasible
therapeutic
interventions
based
microbiome-immune
axis
includes
prebiotics,
probiotics,
postbiotics.
Here,
leverage
conceptual
framework
published
articles
microbiota-based
therapies
target
metastases.
Understanding
complicated
nexus
will
provide
into
fundamental
governing
metastases
subsequently
help
managing
malignancy
better
efficacy.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 24, 2024
Background
The
occurrence
of
immune-related
adverse
events
(irAEs)
seemed
to
be
associated
with
better
outcomes
in
advanced
gastric
cancer
(AGC)
patients.
However,
research
focusing
on
the
impact
single-organ
irAE
(uni-irAE)
or
multi-organ
irAEs
(multi-irAEs)
AGC
outcome
is
relatively
limited.
In
this
study,
we
investigated
individually
different
survival
as
well
co-occurrence
patterns
multi-irAEs.
Methods
uni-irAE,
multi-irAEs,
and
non-irAE
were
identified
based
National
Comprehensive
Cancer
Network
(NCCN)
guidelines.
ICI
efficacy
for
disease
control
rate
(DCR)
objective
response
(ORR)
was
assessed
Response
Evaluation
Criteria
Solid
Tumors
(RECIST)
Version
1.1.
association
progression-free
(PFS)
overall
(OS)
analyzed
using
Kaplan–Meier
method
Cox
regression
model.
We
also
performed
pairwise
correlation
analysis
identify
irAEs.
Results
A
total
288
patients
including
175
non-irAE,
73
40
multi-irAE
evaluated
their
outcome.
displayed
higher
DCR
(78.8%
vs.
67.4%,
p
=0.037)
when
compared
those
patients,
both
uni-irAE
(82.2%
=0.019)
(72.5%
=0.534)
showed
than
that
multivariate
analyses
revealed
multi-irAEs
an
independent
risk
factor
PFS
(hazard
ratio
[HR]
0.63,
95%
confidence
interval
[CI]
0.41~0.96,
=0.031)
OS
(HR
0.47,
CI
0.29~0.76,
=0.002),
whereas
not
obtained.
thyroid,
adrenal
gland,
heart,
skin,
lung
exhibited
a
high
organ-specific
experiencing
skin
had
favorable
without
these
Conclusion
Multi-irAEs
some
can
used
predictive
indicators
treatment
are
often
accompanied
by
occurrence.
