Constipation is associated with an increased risk of major adverse cardiac events in a UK population
AJP Heart and Circulatory Physiology,
Год журнала:
2024,
Номер
327(4), С. H956 - H964
Опубликована: Авг. 16, 2024
Traditional
cardiovascular
risk
factors,
including
hypertension,
only
explain
part
of
major
adverse
cardiac
events
(MACEs).
Understanding
what
other
factors
contribute
to
MACE
is
essential
for
prevention.
Constipation
shares
common
with
hypertension
and
associated
an
increased
several
diseases.
We
hypothesized
that
constipation
underappreciated
factor
MACE.
used
the
population
healthcare
genomic
data
in
UK
Biobank
(
Язык: Английский
Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization.
Gechlang Tang,
Alex V. Carr,
C. Pérez
и другие.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 8, 2025
Absolute
bacterial
biomass
estimation
in
the
human
gut
is
crucial
for
understanding
microbiome
dynamics
and
host-microbe
interactions.
Current
methods
quantifying
stool,
such
as
flow
cytometry,
qPCR,
or
spike-ins
(i.e.,
adding
cells
DNA
from
an
organism
not
normally
found
a
sample),
can
be
labor-intensive,
costly,
confounded
by
factors
like
water
content,
extraction
efficiency,
PCR
inhibitors,
other
technical
challenges
that
add
bias
noise.
We
propose
simple,
cost-effective
approach
circumvents
some
of
these
challenges:
directly
estimating
metagenomes
using
bacterial-to-host
(B:H)
read
ratios.
compare
B:H
ratios
to
standard
outlined
above,
demonstrating
are
useful
proxies
stool
possibly
host-associated
substrates.
show
how
used
track
antibiotic
treatment
response
recovery
both
mice
humans,
which
showed
403-fold
45-fold
reductions
during
treatment,
respectively.
Our
results
indicate
host
metagenomic
fractions
fluctuate
longitudinally
around
stable
mean
healthy
individuals,
average
fraction
varies
across
individuals
<
8-9
fold.
offer
convenient
alternative
absolute
quantification
methods,
without
need
additional
measurements,
experimental
design
considerations,
machine
learning
algorithms,
enabling
retrospective
estimates
existing
data.
Язык: Английский
Rehabilitation for Chronic Constipation: Integrative Approaches to Diagnosis and Treatment
Gastrointestinal Disorders,
Год журнала:
2025,
Номер
7(1), С. 11 - 11
Опубликована: Янв. 22, 2025
Background:
Chronic
constipation
is
a
well-recognized
complication
which
caused
by
hard
and/or
infrequent
defecation.
According
to
estimates,
presents
as
chronic
illness
affecting
16%
of
adults
globally,
who
deal
with
insufficient
bowel
movements
that
cause
discomfort,
bloating,
or
sensation
incomplete
bowel.
Objectives:
This
review
looks
at
the
many
local
and
systemic
factors
contribute
pathogenesis
causative,
including
dietary
habits,
genetic
factors,
colon
function
absorption,
social
economic
lifestyle,
biological
drug
factors.
Results:
Appropriate
diagnostic
management
modalities
are
cornerstone
in
patients
constipation.
However,
there
still
controversies
regarding
timing
these
approaches.
condition
common
reduces
quality
life
represents
burden
on
any
healthcare
system.
In
clinical
practice,
it
remains
problematic,
physicians
most
time
indecisive
therapy
administer
what
time.
Conclusions:
Constipation
new
topic
was
introduced
over
decade
ago
purpose
this
study
shed
some
light
onto
problems
modern
day
techniques
can
be
used
treat
patients,
primarily
through
behavioural,
conservative,
medical,
surgical
means.
Additionally,
particular
conjunction
an
algorithm
designed
enhance
support
practice.
Язык: Английский
Association between dietary index for gut microbiota and chronic kidney disease: A cross-sectional study from U.S. population
Preventive Medicine Reports,
Год журнала:
2025,
Номер
unknown, С. 103060 - 103060
Опубликована: Апрель 1, 2025
Objective:
Emerging
evidence
suggests
that
diet
modulates
gut
microbiota,
which
in
turn
influences
chronic
kidney
disease
(CKD)
progression.
This
study
investigates
the
association
between
newly
proposed
Dietary
Index
for
Gut
Microbiota
(DI-GM)
and
prevalence
prognosis
of
CKD.
Methods:
cross-sectional
analyzed
data
from
U.S.
National
Health
Nutrition
Examination
Survey
2007-2020.
DI-GM
scores
were
calculated
based
on
dietary
intake
14
food
components,
categorized
as
beneficial
or
unfavorable.
Weighted
linear
regression
model,
logistic
restricted
cubic
spline
analysis
used
to
assess
associations
with
Results:
The
CKD
among
28,512
participants
was
17.4
%.
Higher
negatively
associated
(OR
=
0.967,
95
%CI:
0.939-0.995,
p
0.026)
very
high-risk
0.877,
0.821-0.937,
<
0.001).
Beneficial
components
significantly
lower
risk
0.928,
0.892-0.966,
0.001),
while
no
significant
observed
unfavorable
components.
levels
linearly
improved
(p
trend
<0.001).
Coffee
fiber
primary
contributors
both
CKD,
whole
grains
primarily
impacted
its
prognosis.
Conclusions:
DI-GM,
driven
by
is
reduced
These
findings
suggest
promoting
patterns
enhance
microbiota
may
play
a
pivotal
role
management.
Язык: Английский
Senility, defecation disorders, sleep disorders, and non-operative spinal infections: A single-center retrospective analysis
World Journal of Orthopedics,
Год журнала:
2025,
Номер
16(4)
Опубликована: Апрель 16, 2025
Язык: Английский
The relationship of cardiometabolic index with bowel movement frequency: an NHANES-based cross-sectional analysis
Lipids in Health and Disease,
Год журнала:
2025,
Номер
24(1)
Опубликована: Апрель 24, 2025
Prior
studies
have
indicated
a
notable
link
between
gut
health
and
metabolic
syndrome
(MetS).
The
cardiometabolic
index
(CMI),
an
innovative
indicator
of
health,
effectively
predicts
MetS.
Bowel
movement
frequency
(BMF)
closely
reflects
gastrointestinal
function
is
key
sign
health.
Nonetheless,
the
relationship
CMI
BMF
still
unclear.
Our
research
explores
possible
association
these
two
variables.
This
study
employed
2005
to
2010
National
Health
Nutrition
Examination
Survey
data.
for
each
participant
was
determined
by
triglycerides,
high-density
lipoprotein
cholesterol,
waist-to-hip
ratio.
Multiple
regression,
smooth
curve
fitting,
threshold
effect
analyses
were
investigate
BMF.
association's
stability
across
populations
assessed
through
subgroup
interaction
tests.
included
9,678
participants
in
total.
After
controlling
potential
confounding
variables,
those
uppermost
quartile
had
0.69
more
increase
than
bottom
(β
=
0.69,
95%
CI:
0.34,
1.03).
trend
showed
that
increased
steadily
with
advancement
quartiles
(P
<
0.0001).
Associations
shown
be
nonlinear
fitting
analyses.
Specifically,
when
ranged
from
4.97
11.75,
negative
connection
observed
-0.78,
-1.33,
-0.23),
while
positive
associations
identified
other
ranges.
Subgroup
tests
significant
variations
stratified
depression
age
categories
0.05).
indicates
generally
associated
However,
ranges
it
decrease.
Notably,
potent
young,
middle-aged,
depressed
people.
Язык: Английский
Factors affecting postdialysis fatigue among hemodialysis patients: a multi-group path analysis according to nutritional status
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Май 13, 2025
The
aim
was
to
investigate
a
structural
postdialysis
fatigue
model,
verify
the
factors
which
affect
of
hemodialysis
patients,
and
evaluate
moderating
effects
nutritional
status
on
through
multi-group
analysis.
This
multicenter
cross-sectional
study
conducted
in
six
blood
purification
centers
across
hospitals
Taiyuan,
Shanxi,
China,
with
total
1,281
patients
recruited
as
participants.
Data
were
collected
using
Pittsburgh
Sleep
Quality
Index,
Connor-Davidson
Resilience
Scale,
Social
Support
Rate
Post-dialysis
Questionnaire,
Simplified
Nutritional
Appetite
Rome
IV
constipation
diagnostic
criteria.
A
equation
modeling
analysis
then
test
effect
patients.
model's
fit
indices
adequate.
quality,
resilience
social
support
directly
influenced
(β
=
0.181,
-0.322,
-0.200,
p
<
0.01).
partial
mediated
-0.031,
0.038,
0.024,
Multi-group
did
hypothesis
overall
moderation
by
status,
distinct
patterns
between
two
groups
observed
respect
how
background
interpersonal
triggers
related
(Δχ2
28.879,
155.183,
205.135,
210.135,
230.285,
Δdf
6,
9,
11,
14,
17,
magnitude
direct
sleep
quality
greater
poor
(Critical
ratios
for
difference
-1.958,
-4.999).
resilience,
can
fatigue,
also
indirectly
fatigue.
Malnourished
are
more
likely
suffer
from
psychological
Vigorous
efforts
needed
improve
ultimately
might
constipation.
Язык: Английский
Chronic constipation: focus on microbiome-targeted therapies with prebiotics, probiotics, and synbiotics
Almanac of Clinical Medicine,
Год журнала:
2024,
Номер
52(5), С. 280 - 296
Опубликована: Ноя. 4, 2024
Chronic
constipation
is
a
global
medical,
social,
and
economic
problem
due
to
its
negative
impact
on
patients’
quality
of
life
increased
risk
colorectal
cancer,
cardiovascular
cerebrovascular
disorders.
The
gut
microbiota
plays
an
important
role
in
the
pathophysiology
through
interplay
with
immune
system,
enteral
central
nervous
representing
promising
therapeutic
target.
Gut
dysbiosis
patients
characterized
by
reduced
relative
numbers
bacteria
producing
lactate
(Lactobacillaceae,
Bifidobacteriaceae)
butyrate
(Lachnospiraceae,
Oscillospiraceae),
as
well
those
hydrogen
sulfide
(Desulfovibrionaceae)
methanogenic
archaea
(Methanobacteriaceae).
leading
pathogenetic
mechanism
related
intestinal
chronic
constipation,
can
be
microbial
metabolic
abnormalities
(metabolic
dysbiosis)
altered
production
short-chain
fatty
acid,
methane,
sulfide,
tryptophan
metabolites
abnormal
bile
acid
biotransformation.
It
has
been
proven
that
dysbiotic
microbiome
play
which
allows
for
use
prebiotics,
probiotics,
synbiotics
effective
microbiome-modulating
therapy
constipation.
determines
effectiveness
(prebiotics,
synbiotics)
this
syndrome.
Inulin
most
studied
preboitic;
it
soluble
food
fiber
markedly
contributes
regulation
microbiota,
stimulates
growth
beneficial
bacteria,
anti-inflammatory
metabolites.
normalized
function
increasing
stool
frequency,
softening
stool,
reducing
transit
time.
In
addition,
inulin
modulates
response
impacts
absorption
minerals,
appetite,
satiety.
Treatment
probiotics
also
associated
time,
compared
controls.
According
systematic
review
meta-analysis
30
randomized
controlled
trials,
only
Bifidobacterium
lactis
strains
(but
not
other
probiotics)
significantly
increase
frequencies
adults.
Clinical
studies
have
shown
targeted
probiotic
HN019
low
(≤
3
per
week)
frequency
up
4.7–5.0
week,
reduce
time
rate
functional
gastroenterological
symptoms
adults
Beyond
clinical
effects,
leads
changes
bifidobacteria
decreasing
enterobacteria
numbers.
results
trials
confirm
importance
synbiotic
correction
all
improve
fecal
consistency,
prevent
disorders
Synbiotics,
such
combination
inulin,
properties
both
complementary
synergic
synbiotic,
may
greatest
potential
outcomes
or
prebiotics
used
alone.
Язык: Английский