Tumor “age” in early-onset colorectal cancer

Cell, Год журнала: 2025, Номер 188(3), С. 589 - 593

Опубликована: Фев. 1, 2025

Язык: Английский

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Rethinking the rise of early onset gastrointestinal cancers: a call to action

JNCI Cancer Spectrum, Год журнала: 2025, Номер 9(1)

Опубликована: Янв. 3, 2025

Since the early 1990s, there has been a dramatic rise in gastrointestinal cancers diagnosed patients under age 50 for reasons that remain poorly understood. The most significant change increase incidence rates of early-onset colorectal cancer, especially left-sided colon and rectal cancers. Increases gastric, pancreatic, other cancer diagnoses have further contributed to this trend. We formed multidisciplinary Think Tank develop strategic, coordinated approach studying This area research is challenging given multifactorial etiologies. focused on epidemiology environment, microbiome, survivorship as key pillars structure framework. advocate comprehensive strategy (1) use existing biospecimens, those collected longitudinally, with correlation exposures (the exposome); (2) standardize microbiome specimen collection analyses blood, tissue, stool specimens minimize contamination biases; (3) prioritize mechanistic studies evaluate findings from biomarker studies; (4) explore unique needs young population. These recommendations build upon prior efforts goal streamlining into important field study while minimizing redundant efforts. hope our serve clarion call motivate others discover why individuals are being at such an alarming rate how best support who diagnosed.

Язык: Английский

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Home Environment as a Therapeutic Target for Prevention and Treatment of Chronic Diseases: Delivering Restorative Living Spaces, Patient Education and Self-Care by Bridging Biophilic Design, E-Commerce and Digital Health Technologies

International Journal of Environmental Research and Public Health, Год журнала: 2025, Номер 22(2), С. 225 - 225

Опубликована: Фев. 5, 2025

A high prevalence of chronic diseases exposes diverse healthcare pain points due to the limited effectiveness pharmaceutical drugs and biologics, sedentary lifestyles, insufficient health literacy, stress, unsatisfactory patient experience, environmental pollution competition with commercial determinants health. To improve care long-term outcomes, impact home environment is overlooked underutilized by healthcare. This cross-disciplinary work describes perspectives on (1) as a therapeutic target for prevention treatment (2) transforming health-centric household goods e-commerce platforms into digital interventions. We provide rationale creating environments grounded in biophilic design (multisensory, enrichment) supporting physical activities, quality sleep, nutrition, music, stress reduction, self-efficacy, social support education, hence providing clinical benefits through modulation autonomic nervous system, neuroplasticity behavior change. These pleiotropic "active non-pharmacological ingredients" can be personalized people living depression, anxiety, migraine, pain, cancer, cardiovascular other conditions. discuss prospects integrating create "therapeutic environment" interventions delivered therapeutics their combinations prescription drugs. multimodal approach enhance engagement while bridging consumer spending outcomes.

Язык: Английский

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Rural-Urban Disparity in Premature Cancer Mortality in Young People Aged 15–44 Years in China, 2004–2021

International Journal of Public Health, Год журнала: 2025, Номер 70

Опубликована: Фев. 12, 2025

Objective This study aims to examine and compare premature cancer mortality in young people aged 15–44 years old between rural urban areas inform early-onset prevention. Methods The data were obtained from the China Death Surveillance Datasets 2004 2021. sample consisted of deaths old. Age-standardized rates (ASMRs) calculated, joinpoint regressions used trends ASMRs. Results There overall decreasing ASMRs for all cancers both However, decrease was relatively slower areas, where pancreatic ovarian showed increasing trends. five leading types consistently remained liver, lung, leukemia, stomach, other after 2013. Conclusion Our findings indicate that there rural-urban disparities people, which a different pattern compared age groups. More efforts are needed develop effective prevention strategies, with particular emphasis on liver areas.

Язык: Английский

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Comprehensive genomic analysis in sporadic early-onset colorectal adenocarcinoma patients

BMC Cancer, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 25, 2025

The incidence of colorectal cancer (CRC) in young adults has increased worldwide. Our study aimed to evaluate genomic alterations early-onset (aged 15–39 years) sporadic CRC. Formalin-fixed, paraffin-embedded tissue samples from 90 patients with histologically confirmed adenocarcinoma proficient mismatch repair status Siriraj Hospital (Bangkok, Thailand) were extracted. Patients clinically suspected familial adenomatous polyposis excluded. A 517-gene mutational analysis was performed by next-generation sequencing using the Oncomine Comprehensive Assay Plus kit. previously reported molecular data adult-onset CRC our group used as a comparator group. five most frequently mutated genes APC (66%), TP53 (51%), KRAS (47%), ARID1A (31%), and KMT2B (31%). When compare adult-onset, NOTCH1 (11.1% vs. 1.9%), FBXW7 (23.3% 14.8%), PIK3CA (20% 12.1%), FGFR3 (8.9% 3.7%) mutations more prevalent early-onset. No differences observed other common mutations, such TP53, EGFR, KRAS, NRAS BRAF mutations. An prevalence codon 12 also compared (38.9% 29.6%). Overall, landscape between early- appears similar. However, revealed enrichment NOTCH1, FBXW7, PIK3CA, along G12 frequent cases. Further studies larger cohort on comprehensive genetic/epigenetic signatures are required.

Язык: Английский

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The Role of Proteomics and Genomics in the Development of Colorectal Cancer Diagnostic Tools and Potential New Treatments

ACS Pharmacology & Translational Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Язык: Английский

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Universal genetic counseling and testing for Black women: A risk-stratified approach to addressing breast cancer disparities

Clinical Breast Cancer, Год журнала: 2024, Номер 25(3), С. 193 - 197

Опубликована: Дек. 5, 2024

Язык: Английский

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