Bringing ophthalmology into the scientific world: Novel nanoparticle-based strategies for ocular drug delivery DOI
Milad Abbasi, Hossein Aghamollaei, Ahmad Vaez

и другие.

The Ocular Surface, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Emerging role of macrophages in neuropathic pain DOI Creative Commons

Sihan Tong,

Delin Liu, Peng Liao

и другие.

Journal of Orthopaedic Translation, Год журнала: 2025, Номер 51, С. 227 - 241

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Spermine Significantly Increases the Transfection Efficiency of Cationic Polymeric Gene Vectors DOI Creative Commons

Yue Lv,

Jing Xue, Peng‐Fei Cui

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 131 - 131

Опубликована: Янв. 17, 2025

Background/Objectives: Non-viral vectors have gained recognition for their ability to enhance the safety of gene delivery processes. Among these, polyethyleneimine (PEI) stands out as most widely utilized cationic polymer due its accessibility. Traditional methods modifying PEI, such ligand conjugation, chemical derivatization, and cross-linking, are associated with intricate preparation procedures, limited transfection efficiency, suboptimal biocompatibility. Methods: In this investigation, enhanced efficiency was achieved through straightforward physical blending PEI carriers spermine. Results: Transfection assays explored maximal enhancement potential conferred by spermine, alongside further methodological refinements aimed at optimizing efficacy, showcasing a increase up 40.7%. Through comparison different addition sequences optimal complex PEI/Spermine/DNA selected. Characterization revealed that, compared PEI/DNA, particle size increased approximately 150 nm. Molecular dynamics simulation results that spermine can interaction between DNA, thereby forming system lower energy greater stability. Mechanistic inquiries studies also disclosed augments endosomal escape capability without altering pathways involved in cellular uptake nanoparticles, facilitating heightened expression. Conclusions: PEI-Sper emerges promising non-viral vector delivery, distinguished simplicity preparation, cost-effectiveness, superior efficiency.

Язык: Английский

Процитировано

0
Distinct roles of mTORC2 in excitatory and inhibitory neurons in inflammatory and neuropathic pain DOI Creative Commons
Wei He, Xin Ge, Ru‐Rong Ji

и другие.

Brain, Год журнала: 2025, Номер 148(2), С. 357 - 359

Опубликована: Янв. 21, 2025

This scientific commentary refers to ‘Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain’ by Wong et al. (https://doi.org/10.1093/brain/awae275).

Язык: Английский

Процитировано

0
Bringing ophthalmology into the scientific world: Novel nanoparticle-based strategies for ocular drug delivery DOI
Milad Abbasi, Hossein Aghamollaei, Ahmad Vaez

и другие.

The Ocular Surface, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0