Imaging genomics of cancer: a bibliometric analysis and review

Cancer Imaging, Год журнала: 2025, Номер 25(1)

Опубликована: Март 4, 2025

Imaging genomics is a burgeoning field that seeks to connections between medical imaging and genomic features. It has been widely applied explore heterogeneity predict responsiveness disease progression in cancer. This review aims assess current applications advancements of Literature on cancer was retrieved selected from PubMed, Web Science, Embase before July 2024. Detail information articles, such as systems features, were extracted analyzed. Citation Science Scopus. Additionally, bibliometric analysis the included studies conducted using Bibliometrix R package VOSviewer. A total 370 articles study. The annual growth rate 24.88%. China (133) USA (107) most productive countries. top 2 keywords plus "survival" "classification". research mainly focuses central nervous system (121) genitourinary (110, including 44 breast articles). Despite different utilizing modalities, more than half each employed radiomics Publication databases provide data support for research. development artificial intelligence algorithms, especially feature extraction model construction, significantly advanced this field. conducive enhancing related-models' interpretability. Nonetheless, challenges sample size standardization construction must overcome. And trends revealed study will guide future contribute accurate diagnosis treatment clinic.

Язык: Английский

The diagnostic value of a breast cancer diagnosis model based on serum MiRNAs and serum tumor markers

World Journal of Surgical Oncology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 29, 2025

Abstract Background Breast cancer (BCa) is the leading cause of cancer-related death among women worldwide. MicroRNAs (miRNAs) are promising tools for diagnosis and prognosis. This study investigated role serum miRNAs tumor markers (TMs) in BCa. Methods Differentially expressed were screened from samples BCa patients healthy individuals via high-throughput sequencing. The expression hsa-miR-1911-3p, hsa-miR-4694-5p, hsa-miR-548ao-5p, hsa-miR-4804-3p 169 116 controls was detected qRT-PCR. Serum tumor-associated antigens by chemiluminescence. Logistic regression subsequently used to develop miRNA panel I, TM II, (miRNA + TM) III models. Receiver operating characteristic (ROC) curve, precision-recall (PR) curve decision analyses (DCA) performed assess accuracy three models diagnosis. Additionally, relationships between clinical characteristics with assessed. Results Four (hsa-miR-1911-3p, hsa-miR-4804-3p) newly associated I based on hsa-miR-548ao-5p showed greater diagnostic effectiveness than II antigen 125 (CA125) 153 (CA153), AUC values 0.816 0.777, respectively. had higher an value 0.870. miR-548ao-5p miR-4804-3p closely related features, such as human epidermal growth factor receptor 2 (HER2), estrogen (ER), progesterone (PR), HER2-enriched subtype, stage III/IV, lymph node-transplanted breast cancer. Conclusion MiR-548ao-5p miR-4804-3 could serve potential biomarkers

Язык: Английский

Case Report: Multidisciplinary discussion and management of a case involving a non-seminomatous germ cell tumor complicated by the presence of cancerous thrombus in the inferior vena cava

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Апрель 16, 2025

Testicular cancer predominantly manifests in younger males. It demonstrates a favorable response to cisplatin-based chemotherapy and exhibits promising overall survival. Nevertheless, the emergence of certain rare complications, such as development an embolus vena cava due cancer, suggests that tumor high degree aggressiveness is associated with poorer prognosis. We present case stage IIIC mixed malignant germinoma metastases both lungs, left kidney, right paravascular iliac lymph nodes, periaortic inferior thrombus. Following Multi-disciplinary Team (MDT) discussion, treatment modalities including surgery adjuvant were devised, resulting optimal therapeutic outcomes without complications or significant adverse reactions.

Язык: Английский