Glutamine’s double-edged sword: fueling tumor growth and offering therapeutic hope DOI Creative Commons

Liguang Fang,

Dandan Gao, Zhe Jiang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 10, 2025

Tumor metabolic reprogramming is a highly complex process that enables tumor survival in the presence of limited nutrients, involving multiple signaling pathways, non-coding RNAs (ncRNAs), and transcription factors. Lately, glutamine has been found to enhance growth, spread, drug resistance cancer cells, while also fostering an immunosuppressive microenvironment aids development. However, some tumors, such as pancreatic melanoma, additional can inhibit proliferation this mechanism closely related regulation immune microenvironment. Therefore, further exploration metabolism tumors essential for understanding pathogenesis developing new metabolically targeted therapies. We systematically review latest research on its role system regulation. Additionally, we clinical progress therapies their application combination with current anti-tumor treatments. Ultimately, address challenges prospects involved anti-cancer strategies aimed at metabolism.

Язык: Английский

Herbacetin as a Novel Ferroptosis Inhibitor for Mitigating Myocardial Damage Induced by Doxorubicin DOI
Hai Yang, Shaohong Huang,

Xinyu Heng

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Glutamine’s double-edged sword: fueling tumor growth and offering therapeutic hope DOI Creative Commons

Liguang Fang,

Dandan Gao, Zhe Jiang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 10, 2025

Tumor metabolic reprogramming is a highly complex process that enables tumor survival in the presence of limited nutrients, involving multiple signaling pathways, non-coding RNAs (ncRNAs), and transcription factors. Lately, glutamine has been found to enhance growth, spread, drug resistance cancer cells, while also fostering an immunosuppressive microenvironment aids development. However, some tumors, such as pancreatic melanoma, additional can inhibit proliferation this mechanism closely related regulation immune microenvironment. Therefore, further exploration metabolism tumors essential for understanding pathogenesis developing new metabolically targeted therapies. We systematically review latest research on its role system regulation. Additionally, we clinical progress therapies their application combination with current anti-tumor treatments. Ultimately, address challenges prospects involved anti-cancer strategies aimed at metabolism.

Язык: Английский

Процитировано

0