Iodine(III)‐Mediated Migratory gem‐Difluorinations: Synthesis of β Transformable Functionality Substituted gem‐Difluoroalkanes DOI Open Access
Qingjiang Li, Xiaobin Liu, Honggen Wang

и другие.

The Chemical Record, Год журнала: 2023, Номер 23(12)

Опубликована: Сен. 4, 2023

Abstract Geminal‐difluoroalkanes featuring intriguing steric and electronic properties are of great significance in medicinal chemistry, progresses have been achieved for their synthesis. In recent years, iodine(III) reagent‐mediated migratory gem ‐difluorination alkenes has proved to be an efficient powerful strategy access diverse ‐difluoroalkanes, especially those bearing a readily transformable functionality (TF), which important rapid assembly complex ‐difluorinated molecules modular manner. this review, we systematically summarize the development iodine(III)‐mediated reactions synthesis ‐difluoroalkanes synthetically versatile TF at β position. The reaction mechanism utilities products also discussed. This review is presented grouped basically according types functionalities within products.

Язык: Английский

Synthesis of highly substituted 1,3-dienes through halonium promoted 1,2-sulfur migration of propargylic thioethers DOI Creative Commons
Clara Martínez‐Núñez, Noelia Velasco, Roberto Sanz

и другие.

Chemical Communications, Год журнала: 2024, Номер 60(13), С. 1794 - 1797

Опубликована: Янв. 1, 2024

Highly regio- and diastereoselective synthesis of 2-thiorganyl 1-bromo or 1-iodo-1,3-dienes is reported via 1,2-sulfur migration propargylic sulfides. These dienes are precursors thiophenes selenophenes by reaction with sulfur selenium.

Язык: Английский

Процитировано

4
Iodine(III)‐Mediated Migratory gem‐Difluorinations: Synthesis of β Transformable Functionality Substituted gem‐Difluoroalkanes DOI Open Access
Qingjiang Li, Xiaobin Liu, Honggen Wang

и другие.

The Chemical Record, Год журнала: 2023, Номер 23(12)

Опубликована: Сен. 4, 2023

Abstract Geminal‐difluoroalkanes featuring intriguing steric and electronic properties are of great significance in medicinal chemistry, progresses have been achieved for their synthesis. In recent years, iodine(III) reagent‐mediated migratory gem ‐difluorination alkenes has proved to be an efficient powerful strategy access diverse ‐difluoroalkanes, especially those bearing a readily transformable functionality (TF), which important rapid assembly complex ‐difluorinated molecules modular manner. this review, we systematically summarize the development iodine(III)‐mediated reactions synthesis ‐difluoroalkanes synthetically versatile TF at β position. The reaction mechanism utilities products also discussed. This review is presented grouped basically according types functionalities within products.

Язык: Английский

Процитировано

6