Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation

Organic Process Research & Development, Год журнала: 2024, Номер 28(4), С. 831 - 846

Опубликована: Март 8, 2024

We present and analyze the results of a pharmaceutical industry-wide survey strategies approaches that companies have for implementing photochemical reactions in discovery chemistry, process development, commercial manufacturing. The questions encompass types pursue why, reactors (batch flow) used, how they are characterized photochemistry, scale-up reactions, prioritize resources developing among other topics. focuses on many these topics from perspectives chemists scientists to highlight similarities differences between their specific transformations materials construction used reactors. clearly demonstrate photochemistry is viable synthetic strategy producing active ingredients (APIs), all way commercialization. While more prevalent early stage indicate leveraging successful scale-ups later stages often using flow significant knowledge resulting experiences. Nevertheless, there still gaps adopting across development very limited experience discussing with regulatory agencies. Overall, offers considerable benefits synthesizing APIs API processes, such as greenness sustainability, shortening routes, potential improved product quality.

Язык: Английский

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High‐Throughput Exploration of a Thioxanthone‐catalyzed Photoredox C−O Coupling

ChemPhotoChem, Год журнала: 2024, Номер 8(6)

Опубликована: Фев. 9, 2024

Abstract Using High‐Throughput Experimentation (HTE), a visible light‐mediated etherification method was developed, employing the organic photocatalyst thioxanthen‐9‐one (TXO) and commercially available, air‐stable nickel source. Design of Experiments (DoE) techniques were utilized in conjunction with HTE to identify optimal reaction conditions which are mild, cost‐effective, robust therefore suitable for use an industrial setting. A diverse substrate scope prepared via parallel synthesis selected examples demonstrated on 4.2 mmol scale batch. Furthermore, successfully performed 83 scale, utilizing standard jacketed reactor Kessil PR160 L lamps.

Язык: Английский

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A review on sustainable synthesis methods, characterization and applications of inorganic metal complexes: Recent advances and future approaches

Results in Chemistry, Год журнала: 2024, Номер 10, С. 101743 - 101743

Опубликована: Авг. 1, 2024

Язык: Английский

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Synthesis of 3-Chloro-6-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)pyridazine and Its Deuterated Analogue

Russian Journal of General Chemistry, Год журнала: 2024, Номер 94(11), С. 2833 - 2840

Опубликована: Ноя. 1, 2024

Язык: Английский

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