Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues
Human Genomics,
Год журнала:
2025,
Номер
19(1)
Опубликована: Янв. 31, 2025
Non-communicable
diseases
(NCDs)
such
as
cardiovascular
diseases,
chronic
respiratory
cancers,
diabetes,
and
mental
health
disorders
pose
a
significant
global
challenge,
accounting
for
the
majority
of
fatalities
disability-adjusted
life
years
worldwide.
These
arise
from
complex
interactions
between
genetic,
behavioral,
environmental
factors,
necessitating
thorough
understanding
these
dynamics
to
identify
effective
diagnostic
strategies
interventions.
Although
recent
advances
in
multi-omics
technologies
have
greatly
enhanced
our
ability
explore
interactions,
several
challenges
remain.
include
inherent
complexity
heterogeneity
multi-omic
datasets,
limitations
analytical
approaches,
severe
underrepresentation
non-European
genetic
ancestries
most
omics
which
restricts
generalizability
findings
exacerbates
disparities.
This
scoping
review
evaluates
landscape
data
related
NCDs
2000
2024,
focusing
on
advancements
integration,
translational
applications,
equity
considerations.
We
highlight
need
standardized
protocols,
harmonized
data-sharing
policies,
advanced
approaches
artificial
intelligence/machine
learning
integrate
study
gene-environment
interactions.
also
opportunities
translating
insights
(GxE)
research
into
precision
medicine
strategies.
underscore
potential
advancing
enhancing
patient
outcomes
across
diverse
underserved
populations,
emphasizing
fairness-centered
strategic
investments
build
local
capacities
underrepresented
populations
regions.
Язык: Английский
Linking Antibiotic Residues and Antibiotic Resistance Genes to Water Quality Parameters in Urban Reservoirs: A Seasonal Perspective
Environments,
Год журнала:
2025,
Номер
12(3), С. 96 - 96
Опубликована: Март 18, 2025
The
interaction
between
antibiotics
and
antibiotic
resistance
genes
(ARGs)
in
freshwater
ecosystems
has
become
a
critical
environmental
concern.
This
study
investigates
seasonal
variations
of
sulfonamide
tetracycline
their
relationship
with
ARGs
three
urban
reservoirs
Nanjing,
China:
Pingshan
Forest
Park,
Shanhu
Lake
Wetland
Zhaoqiao
Reservoir.
Sampling
was
conducted
May
September
2023
to
assess
water
quality,
concentrations,
ARG
abundance.
A
total
30
samples
were
analyzed
regard
physicochemical
parameters,
heavy
metals,
antibiotics.
quantitative
PCR
assay
used
measure
the
abundance
relative
16S
rRNA
gene.
Sulfonamide
concentrations
ranged
from
120
ng/L,
while
tetracyclines
50–160
ng/L.
Notably,
sulfamethazine
decreased
significantly
two
(Shanhu
Zhaoqiao,
p
<
0.05),
other
showed
minimal
variation,
indicating
persistent
contamination
agricultural
runoff
wastewater
discharge.
lower
than
September,
being
cumulatively
genes.
Strong
correlations
(r
>
0.7)
observed
parameters
like
dissolved
oxygen
pH.
High
levels
areas
without
nearby
hospitals
or
pharmaceutical
companies,
implicating
agriculture
as
major
pollution
source.
By
analyzing
across
eutrophic
China,
we
highlight
drivers
proliferation
propose
targeted
mitigation
strategies.
Язык: Английский
Environmental Pollutants and Atherosclerosis: Epigenetic Mechanisms Linking Genetic Risk and Disease
Atherosclerosis,
Год журнала:
2025,
Номер
unknown, С. 119131 - 119131
Опубликована: Фев. 1, 2025
Язык: Английский
Single-Ligand Modulated Size-Dependent Multi-Color Au/Os Nanoclusters for Multi-Analyte Detection
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
The
development
of
nanoclusters
(NCs)
capable
multicolor
emissions
for
simultaneous
detection
multiple
analytes
has
aroused
tremendous
interest.
However,
the
current
methods
synthesizing
NCs
with
mainly
depend
on
a
ligand
strategy,
which
not
only
compromises
stability
but
also
alters
their
physicochemical
properties.
Herein,
we
propose
novel
strategy
designing
single-ligand
capped
bimetallic
Au/Os
fluorescence
by
adjusting
size
NCs.
This
size-controlled,
encapsulation
enhances
and
compatibility
ensures
uniformity
in
properties,
thereby
overcoming
limitations
inherent
multiligand
systems.
By
meticulously
modulating
reaction
parameters,
achieved
precise
tuning
size,
resulting
synthesis
fluorescent
displaying
blue
(465
nm),
green
(507
yellow
(560
nm)
emissions.
These
were
then
incorporated
into
an
array
system
differentiation
tetracyclines
(TCs)
virtue
interaction
TCs
through
inner
filter
effect
(IFE).
Finally,
each
TC
elicited
unique
response,
was
subsequently
analyzed
principal
component
analysis.
sensor
been
successfully
employed
milk,
urine,
water,
demonstrating
its
practical
application
potential.
developed
this
work
holds
great
promise
Язык: Английский
Artificial intelligence: A key fulcrum for addressing complex environmental health issues
Environment International,
Год журнала:
2025,
Номер
unknown, С. 109389 - 109389
Опубликована: Март 1, 2025
Язык: Английский
fastGxE: Powering genome-wide detection of genotype-environment interactions in biobank studies
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
Abstract
Traditional
genome-wide
association
studies
(GWAS)
have
primarily
focused
on
detecting
main
genotype
effects,
often
overlooking
genotype-environment
interactions
(GxE),
which
are
essential
for
understanding
context-specific
genetic
effects
and
refining
disease
etiology.
Here,
we
present
fastGxE,
a
scalable
effective
GxE
method
designed
to
identify
variants
that
interact
with
environmental
factors
influence
traits
of
interest.
fastGxE
controls
both
polygenic
interaction
is
robust
the
number
involved
in
interactions,
ensures
scalability
analysis
large
biobank
studies,
achieving
speed
improvements
32.98-126.49
times
over
existing
approaches.
We
illustrate
benefits
through
extensive
simulations
an
in-depth
32
physical
67
blood
biomarkers
from
UK
Biobank.
In
real
data
applications,
identifies
nine
genomic
loci
associated
traits,
including
six
novel
ones,
26
biomarkers,
19
novel.
The
new
discoveries
highlight
dynamic
interplay
between
genetics
environment,
uncovering
potentially
clinically
significant
pathways
could
inform
personalized
interventions
treatment
strategies.
Язык: Английский
Ethical, Legal, and Social Implications of Gene‐Environment Interaction Research
Genetic Epidemiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 24, 2024
ABSTRACT
Many
complex
disorders
are
impacted
by
the
interplay
of
genetic
and
environmental
factors.
In
gene‐environment
interactions
(GxE),
an
individual's
epigenetic
makeup
impacts
response
to
exposures.
Understanding
GxE
can
impact
health
at
individual,
community,
population
levels.
The
rapid
expansion
research
in
biomedical
studies
for
diseases
raises
many
unique
ethical,
legal,
social
implications
(ELSIs)
that
have
not
been
extensively
explored
addressed.
This
review
article
builds
on
discussions
originating
from
a
workshop
held
National
Institute
Environmental
Health
Sciences
(NIEHS)
Human
Genome
Research
(NHGRI)
January
2022,
entitled:
“Ethical,
Legal,
Social
Implications
Gene‐Environment
Interaction
Research.”
We
expand
upon
multiple
key
themes
inform
broad
recommendations
general
guidance
addressing
some
most
challenging
ELSI
research.
Key
takeaways
include
strategies
approaches
establishing
sustainable
community
partnerships,
incorporating
determinants
justice
considerations
into
research,
effectively
communicating
translating
findings,
privacy
discrimination
concerns
all
going
forward.
Additional
guidelines,
resources,
approaches,
training,
capacity
building
required
further
support
innovative
multidisciplinary
teams.
Язык: Английский
Mutational Signatures in Cancer Genomics and Toxicology
Elsevier eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Developmental Immunotoxicology – Alternative Methods
Elsevier eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Epigenetic biomarkers of autoimmune risk and protective antioxidant signaling in methylmercury-exposed adults
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2022,
Номер
unknown
Опубликована: Июль 6, 2022
I.
Abstract
Background
Epigenome-wide
association
studies
(EWAS)
are
a
highly
promising
approach
that
can
inform
precision
environmental
health.
However,
current
EWAS
underpowered
for
biomarker
detection
and
increasing
sample
sizes
will
require
substantial
resources.
Therefore,
alternative
approaches
identifying
candidate
biomarkers
through
critical
moving
the
field
forward.
Objectives
To
provide
proof-of-principle
maximizing
exposure
variance
in
by
selecting
participants
from
disproportionately
exposed
global
populations
enables
effective
detection,
even
small
sizes.
Methods
We
profiled
genome-wide
DNA
methylation
using
Illumina
Infinium
MethylationEPIC
BeadChip
whole
blood
N=32
individuals
Madre
de
Dios,
Peru
with
high
methylmercury
(MeHg)
due
to
artisanal
small-scale
gold
mining.
compared
N=16
(>10
μg/g)
vs.
low
(<1
total
hair
mercury
(a
proxy
exposure),
matched
on
age
sex.
Results
identified
nine
differentially
methylated
CpG
sites
(FDR<0.05),
including
several
known
links
MeHg
toxicity.
The
most
significantly
different
site
was
an
intronic
enhancer
of
SLC5A7
gene,
which
encodes
L-type
amino
acid
transporter
1
(LAT1)
facilitates
transport
into
protein-rich
tissue,
muscle
brain.
Our
Gene
Ontology
transcription
factor
motif
enrichment
analyses
differential
genes
involved
outcomes
established
MeHg,
immune
response,
neurotoxicity,
type
2
diabetes
(T2D)
risk.
Last,
we
epigenetic
PUFA-mediated
protection
against
Discussion
Here,
show
samples
detect
CpGs
pathways
interest
relevant
biology.
Similar
be
leveraged
develop
targeted,
custom
sequencing
panels
microarrays
limited
replicated,
validated
given
exposure.
Язык: Английский