Associations Between Clinical Manifestations of SARS-CoV-2 Infection and HLA Alleles in a Caucasian Population: A Molecular HLA Typing Study DOI Open Access
Bogusław Tymoniuk, Maciej Borowiec, Joanna Makowska

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(24), С. 7695 - 7695

Опубликована: Дек. 17, 2024

Background and Objectives: Severe COVID-19 still constitutes an important health problem. Taking into account the crucial role of HLA in immune reactions, evaluation impact on risk clinical course seemed necessary, as already available data are inconsistent. The aim present study was to compare profiles patients with symptomatic SARS-CoV-2 infection a healthy control group, well allele frequencies severe non-severe courses COVID-19. Materials Methods: classes were genotyped using next-generation sequencing method 2322 persons, including 2217 hematopoietic stem cell potential donors 105 Results: Symptomatic appeared be associated presence HLA-A*30:01, B*44:02, B*52:01, C*05:01, C*17:01, DRB1*11:02, while HLA-C*07:04 DQB1*03:03 seem play protective role. Moreover, we demonstrated that can HLA-B*08:01, C*04:01, DRB1*03:01, DQB1*03:01, HLA-DRB1*08:01 against disease. Conclusions: Identification alleles potentially broadens knowledge genetic background constitute step development personalized medicine.

Язык: Английский

Response to the Letter to the Editor: Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection DOI Creative Commons
Astrid Marchal, Vanessa Sancho‐Shimizu, Laurent Abel

и другие.

Human Genetics and Genomics Advances, Год журнала: 2025, Номер 6(2), С. 100407 - 100407

Опубликована: Янв. 18, 2025

Язык: Английский

Процитировано

0
Associations Between Clinical Manifestations of SARS-CoV-2 Infection and HLA Alleles in a Caucasian Population: A Molecular HLA Typing Study DOI Open Access
Bogusław Tymoniuk, Maciej Borowiec, Joanna Makowska

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(24), С. 7695 - 7695

Опубликована: Дек. 17, 2024

Background and Objectives: Severe COVID-19 still constitutes an important health problem. Taking into account the crucial role of HLA in immune reactions, evaluation impact on risk clinical course seemed necessary, as already available data are inconsistent. The aim present study was to compare profiles patients with symptomatic SARS-CoV-2 infection a healthy control group, well allele frequencies severe non-severe courses COVID-19. Materials Methods: classes were genotyped using next-generation sequencing method 2322 persons, including 2217 hematopoietic stem cell potential donors 105 Results: Symptomatic appeared be associated presence HLA-A*30:01, B*44:02, B*52:01, C*05:01, C*17:01, DRB1*11:02, while HLA-C*07:04 DQB1*03:03 seem play protective role. Moreover, we demonstrated that can HLA-B*08:01, C*04:01, DRB1*03:01, DQB1*03:01, HLA-DRB1*08:01 against disease. Conclusions: Identification alleles potentially broadens knowledge genetic background constitute step development personalized medicine.

Язык: Английский

Процитировано

0