Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Июнь 22, 2023
Colorectal
cancer
(CRC)
is
a
prevalent
malignancy
that
affects
large
percentage
of
the
global
population.
The
conventional
treatments
for
CRC
have
number
limitations.
Nanoparticles
emerged
as
promising
treatment
method
due
to
their
ability
directly
target
cells
and
regulate
drug
release,
thereby
enhancing
therapeutic
efficacy
minimizing
side
effects.
This
compilation
examines
use
nanoparticles
delivery
systems
treatment.
Different
nanomaterials
can
be
used
administer
anticancer
drugs,
including
polymeric
nanoparticles,
gold
liposomes,
solid
lipid
nanoparticles.
In
addition,
we
discuss
recent
developments
in
nanoparticle
preparation
techniques,
such
solvent
evaporation,
salting-out,
ion
gelation,
nanoprecipitation.
These
methods
demonstrated
high
penetrating
epithelial
cells,
prerequisite
effective
delivery.
article
focuses
on
various
targeting
mechanisms
utilized
by
CRC-targeted
advancements
this
field.
review
offers
descriptive
information
regarding
numerous
nano-preparative
procedures
colorectal
treatments.
We
also
outlook
innovative
techniques
management
CRC,
potential
application
targeted
concludes
with
discussion
current
nanotechnology
patents
clinical
studies
diagnose
CRC.
results
investigation
suggest
great
cancer.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 1322 - 1322
Опубликована: Янв. 22, 2024
Natural
polysaccharides,
which
are
described
in
this
study,
some
of
the
most
extensively
used
biopolymers
food,
pharmaceutical,
and
medical
applications,
because
they
renewable
have
a
high
level
biocompatibility
biodegradability.
The
fundamental
understanding
required
to
properly
exploit
polysaccharides
potential
biocomposite,
nanoconjugate,
pharmaceutical
industries
depends
on
detailed
research
these
molecules.
Polysaccharides
preferred
over
other
polymers
their
biocompatibility,
bioactivity,
homogeneity,
bioadhesive
properties.
also
been
discovered
excellent
rheological
biomucoadhesive
properties,
may
be
design
create
variety
useful
cost-effective
drug
delivery
systems.
Polysaccharide-based
composites
derived
from
natural
sources
widely
exploited
due
multifunctional
particularly
systems
biomedical
applications.
These
materials
achieved
global
attention
great
demand
biochemical
mimic
both
human
animal
cells.
Although
synthetic
account
for
substantial
amount
organic
chemistry,
play
vital
role
range
industries,
including
biomedical,
construction.
As
consequence,
current
study
will
provide
information
polymers,
biological
uses,
food
Polymers,
Год журнала:
2022,
Номер
14(16), С. 3266 - 3266
Опубликована: Авг. 11, 2022
Bleeding
control
plays
a
very
important
role
in
worldwide
healthcare,
which
also
promotes
research
and
development
of
wound
dressings.
The
healing
process
involves
four
stages
hemostasis,
inflammation,
proliferation
remodeling,
is
complex
process,
dressings
play
huge
it.
Electrospinning
technology
simple
to
operate.
Electrospun
nanofibers
have
high
specific
surface
area,
porosity,
oxygen
permeability,
excellent
mechanical
properties,
show
great
utilization
value
the
manufacture
As
one
most
popular
reactive
functional
synthetic
polymers,
polyacrylonitrile
(PAN)
frequently
explored
create
for
wide
variety
applications.
In
recent
years,
researchers
invested
application
PAN
Research
on
spun
reviewed,
future
directions
prospects
electrospun
are
proposed.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 657 - 657
Опубликована: Фев. 15, 2023
The
topical
route
is
the
most
appropriate
for
targeted
delivery
of
drugs
to
skin
tissues
treatment
local
diseases;
however,
stratum
corneum
(SC),
foremost
layer
skin,
acts
as
a
major
barrier.
Numerous
passive
and
active
drug
techniques
have
been
exploited
overcome
this
barrier;
these
modalities
are
associated
with
several
detrimental
effects
which
restrict
their
clinical
applicability.
Alternatively,
nanotechnology-aided
interventions
extensively
investigated
administration
wide
range
therapeutics.
In
review,
we
mainly
focused
on
biopharmaceutical
significance
polymeric
nanoparticles
(PNPs)
(made
from
natural
polymers)
various
diseases
such
psoriasis,
atopic
dermatitis
(AD),
infection,
cancer,
acute-to-chronic
wounds,
acne.
encapsulation
drug(s)
into
inner
core
or
adsorption
onto
shell
PNPs
has
shown
marked
improvement
in
physicochemical
properties,
avoiding
premature
degradation
controlling
release
kinetics,
permeation
through
SC,
retention
layers.
Furthermore,
functionalization
PEGylation,
conjugation
targeting
ligand,
pH/thermo-responsiveness
further
success
optimizing
therapeutic
efficacy
diseases.
Despite
enormous
progress
development
PNPs,
translation
still
lacking,
could
be
potential
future
perspective
researchers
working
field.
Pharmaceutics,
Год журнала:
2023,
Номер
15(4), С. 1142 - 1142
Опубликована: Апрель 4, 2023
Alginate
is
a
naturally
derived
polysaccharide
widely
applied
in
drug
delivery,
as
well
regenerative
medicine,
tissue
engineering
and
wound
care.
Due
to
its
excellent
biocompatibility,
low
toxicity,
the
ability
absorb
high
amount
of
exudate,
it
used
modern
dressings.
Numerous
studies
indicate
that
alginate
care
can
be
enhanced
with
incorporation
nanoparticles,
revealing
additional
properties
beneficial
healing
process.
Among
most
extensively
explored
materials,
composite
dressings
loaded
antimicrobial
inorganic
nanoparticles
mentioned.
However,
other
types
antibiotics,
growth
factors,
active
ingredients
are
also
investigated.
This
review
article
focuses
on
recent
findings
regarding
novel
alginate-based
materials
their
applicability
dressings,
special
attention
paid
potential
use
treatment
chronic
wounds.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 786 - 786
Опубликована: Янв. 8, 2024
Studies
on
bionanocomposite
drug
carriers
are
a
key
area
in
the
field
of
active
substance
delivery,
introducing
innovative
approaches
to
improve
therapy.
Such
play
crucial
role
enhancing
bioavailability
substances,
affecting
therapy
efficiency
and
precision.
The
targeted
delivery
drugs
sites
action
minimization
toxicity
body
is
becoming
possible
through
use
these
advanced
carriers.
Recent
research
has
focused
structures
based
biopolymers,
including
lipids,
polysaccharides,
proteins.
This
review
paper
description
lipid-containing
nanocomposite
(including
liposomes,
lipid
emulsions,
nanoparticles,
solid
nanostructured
carriers),
polysaccharide-containing
alginate
cellulose),
protein-containing
(e.g.,
gelatin
albumin).
It
was
demonstrated
many
investigations
that
such
show
ability
load
therapeutic
substances
efficiently
precisely
control
release.
They
also
desirable
biocompatibility,
which
promising
sign
for
their
potential
application
development
indicates
novel
approach
improving
processes,
contribute
significant
advances
pharmacology,
efficacy
while
minimizing
side
effects.
