Development and Characterization of Luteolin Loaded Niosomesfor Effective Deliveryin Wound Healing DOI Open Access

D.M. Puri,

Harish Bhardwaj, Rajendra Jangde

и другие.

Biosciences Biotechnology Research Asia, Год журнала: 2025, Номер 22(1), С. 375 - 394

Опубликована: Март 25, 2025

ABSTRACT: This study focuses on the development of luteolin-loaded niosomes aimed at enhancing therapeutic efficacy and bioavailability luteolin for wound healing applications. Luteolin, despite its potential, faces significant limitations such as low absorption, poor water solubility, reduced bioavailability. To overcome these challenges, a sustained-release formulation was developed topical application. The optimized using Design Expert software (Version 11) inBox-Behnken (BBD) through response surface methodology. Niosomes were prepared via thinfilm hydration method, with three factors two levels used in optimization process. niosomal preparationswere evaluated by polydispersity index (PDI), zeta vesicle size, entrapment efficiency (EE), Fouriertransform infrared spectroscopy (FTIR), in-vitro drug release profile. showed size 267.2 nm, PDI 0.34, potential -20.25 mV, an EE 78.31%. In-vitro studies established sustained 67.08% over 12 hours. These results demonstrate that formulations have release, improving shows promise addressing issues effectiveness management.

Язык: Английский

Development and Characterization of Luteolin Loaded Niosomesfor Effective Deliveryin Wound Healing DOI Open Access

D.M. Puri,

Harish Bhardwaj, Rajendra Jangde

и другие.

Biosciences Biotechnology Research Asia, Год журнала: 2025, Номер 22(1), С. 375 - 394

Опубликована: Март 25, 2025

ABSTRACT: This study focuses on the development of luteolin-loaded niosomes aimed at enhancing therapeutic efficacy and bioavailability luteolin for wound healing applications. Luteolin, despite its potential, faces significant limitations such as low absorption, poor water solubility, reduced bioavailability. To overcome these challenges, a sustained-release formulation was developed topical application. The optimized using Design Expert software (Version 11) inBox-Behnken (BBD) through response surface methodology. Niosomes were prepared via thinfilm hydration method, with three factors two levels used in optimization process. niosomal preparationswere evaluated by polydispersity index (PDI), zeta vesicle size, entrapment efficiency (EE), Fouriertransform infrared spectroscopy (FTIR), in-vitro drug release profile. showed size 267.2 nm, PDI 0.34, potential -20.25 mV, an EE 78.31%. In-vitro studies established sustained 67.08% over 12 hours. These results demonstrate that formulations have release, improving shows promise addressing issues effectiveness management.

Язык: Английский

Процитировано

0