Aboral cell types of Clytia and coral larvae have shared features and link taurine to the regulation of settlement
Science Advances,
Год журнала:
2025,
Номер
11(20)
Опубликована: Май 16, 2025
Larval
settlement
is
of
interest
both
for
ecologists
and
evolutionary
biologists,
who
have
proposed
that
anterior
sensory
systems
substrate
selection
provided
the
basis
animal
brains.
Nevertheless,
cellular
molecular
regulation
settlement,
including
in
Cnidaria
(corals,
jellyfish,
sea
anemones,
hydroids),
not
well
understood.
We
generated
compared
(aboral)
transcriptomes
single-cell
RNA
sequencing
datasets
from
planula
larvae
three
cnidarian
species:
jellyfish
Clytia
hemisphaerica
corals
Astroides
calycularis
Pocillopora
acuta
.
Integrating
these
characterizing
aboral
cell
types,
we
defined
common
features
end
identified
clade-specific
specializations
types.
Among
shared
were
genes
implicated
taurine
uptake
catabolism
expressed
distinct
specialized
In
functional
assays
using
planulae,
exogenous
inhibited
settlement.
These
findings
define
architecture
pole
implicate
localized
destruction
regulating
Язык: Английский
Candidate stem cell isolation and transplantation in Hexacorallia
Cell Reports,
Год журнала:
2024,
Номер
43(11), С. 114944 - 114944
Опубликована: Ноя. 1, 2024
Stem
cells
are
the
foundation
for
cell
therapy
due
to
their
ability
self-renew,
differentiate
into
other
types,
and
persist
throughout
life
of
an
organism.
isolation
transplantation
have
not
yet
been
established
in
Hexacorallia,
a
cnidarian
subclass
containing
stony
corals
sea
anemones.
Here,
we
demonstrate
that
candidate
stem
hexacorallian
Nematostella
vectensis
can
be
transplanted
adult
animals.
These
exhibited
hallmarks
functional
properties;
they
integrated
recipients'
tissues
rescued
them
from
lethal
doses
chemotherapy.
Additionally,
these
proliferated
survived
serial
transplantations.
Notably,
showed
this
cellular
subpopulation
enriched
by
sorting
using
species-non-specific
markers
similar
subpopulations
isolated
hexacorallians,
including
corals.
This
research
establishes
basis
studying
biology
on
level
Hexacorallia.
Язык: Английский
Aboral cell types of Clytia and coral larvae have shared features and link taurine to the regulation of settlement
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 3, 2024
Abstract
Planktonic
larvae
of
many
marine
invertebrates
settle
on
a
suitable
substrate
and
metamorphose
into
bottom-dwelling
adults.
Larval
settlement
is
considerable
interest
both
for
ecologists
evolutionary
biologists,
who
have
proposed
that
anterior
sensory
systems
selection
provided
the
basis
animal
brains.
Nevertheless
cellular
molecular
regulation
larval
settlement,
including
in
Cnidaria
(corals,
jellyfish,
sea
anemones,
hydroids)
not
well
understood.
We
generated
compared
(aboral)
transcriptomes
single-cell
RNA-seq
datasets
from
planula
three
cnidarian
species:
hydrozoan
jellyfish
Clytia
hemisphaerica,
scleractinian
corals
Astroides
calycularis
Pocillopora
acuta
.
Integrating
these
characterizing
aboral
cell
types,
we
defined
common
architecture
end,
identified
clade-specific
specializations
unique
neural
cells
neurosecretory
types
with
distinct
signatures
coral
planulae.
Among
features
were
genes
implicated
taurine
uptake
catabolism
expressed
specialized
types.
In
functional
assays,
exogenous
inhibited
These
findings
define
detailed
framework
pole,
implicate
localized
destruction
defining
competence.
Язык: Английский