Exploring the effect of SGLT2 inhibitors on the risk of primary open-angle glaucoma using Mendelian randomization analysis

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 22, 2025

This study aimed to evaluate the causal effect of sodium-glucose cotransporter protein 2 (SGLT2) inhibition on primary open-angle glaucoma (POAG) and explore potential mechanisms. A drug-targeted Mendelian randomization (MR) was conducted using genetic variation related SGLT2 inhibition, based gene expression glycated hemoglobin levels. Genetic summary statistics for POAG were obtained from FinnGen consortium a multi-ancestry genome-wide association study. Glaucomatous endophenotype data also incorporated. two-step MR analysis performed examine whether pathways obesity, blood pressure, lipid levels, oxidative stress, inflammation mediated between POAG. Genetically predicted associated with reduced risk (OR: 0.28; 95% CI: 0.12 0.63; P = 2.22 × 10- 3), confirmed in validation cohort. It decreased optic cup area, vertical cup-disc ratio, increased disc area. Mediation indicated that partly by diastolic pressure (4.8%). suggests is promising therapeutic target However, further large-scale randomized controlled trials are required confirm these findings.

Язык: Английский

Ketogenic Diet and Neuroinflammation: Implications for Neuroimmunometabolism and Therapeutic Approaches to Refractory Epilepsy

Nutrients, Год журнала: 2024, Номер 16(23), С. 3994 - 3994

Опубликована: Ноя. 22, 2024

Refractory epilepsy, characterized by seizures that do not respond to standard antiseizure medications, remains a significant clinical challenge. The central role of the immune system on occurrence epileptic disorders has been long studied, but recent perspectives immunometabolism and neuroinflammation are reshaping scientific knowledge. ketogenic diet its variants have considered an important medical nutrition therapy for refractory epilepsy may potential modulation effect system, specifically, metabolism cells. In this comprehensive review, we gathered current evidence-based practice, interventional ongoing trials addressing in epilepsy. We also discussed detail anticonvulsant mechanisms, neuroimmunometabolism, highlighting Th17/Treg homeostasis as one most interesting aspects deserving consideration future trials.

Язык: Английский

Sodium-glucose cotransporter protein 2 inhibition, plasma proteins, and ischemic stroke: A mediation Mendelian randomization and colocalization study

Journal of Stroke and Cerebrovascular Diseases, Год журнала: 2024, Номер 34(1), С. 108136 - 108136

Опубликована: Ноя. 12, 2024

To determine the effect of sodium-glucose cotransporter protein 2 (SGLT2) inhibition on ischemic stroke (IS) and investigate circulating proteins that mediate effects SGLT2 IS.

Язык: Английский