The role of neutrophils in osteosarcoma: insights from laboratory to clinic DOI Creative Commons
Ming Xia, Yu Han,

Lihui Sun

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 8, 2024

Osteosarcoma, a highly aggressive malignant bone tumor, is significantly influenced by the intricate interactions within its tumor microenvironment (TME), particularly involving neutrophils. This review delineates multifaceted roles of neutrophils, including tumor-associated neutrophils (TANs) and neutrophil extracellular traps (NETs), in osteosarcoma’s pathogenesis. TANs exhibit both pro- anti-tumor phenotypes, modulating growth immune evasion, while NETs facilitate cell adhesion, migration, immunosuppression. Clinically, neutrophil-related markers such as neutrophil-to-lymphocyte ratio (NLR) predict patient outcomes, highlighting potential for neutrophil-targeted therapies. Unraveling these complex crucial developing novel treatment strategies that harness TME to improve osteosarcoma management.

Язык: Английский

Sivelestat sodium protects against renal ischemia/reperfusion injury by reduction of NETs formation DOI
Yanqi Liu, Yu Xin, Mengyao Yuan

и другие.

Archives of Biochemistry and Biophysics, Год журнала: 2025, Номер 765, С. 110318 - 110318

Опубликована: Янв. 23, 2025

Язык: Английский

Процитировано

1
Diosmetin Inhibits NETs Formation in Neutrophils Through Regulating Nrf2 Signaling DOI Creative Commons
Lijuan Guo,

Hongyang Luo,

Yuxin Lei

и другие.

Thoracic Cancer, Год журнала: 2025, Номер 16(6)

Опубликована: Март 1, 2025

Neutrophil extracellular traps (NETs) are important pieces of equipment for neutrophils. Excess NETs play promoting roles in cancer-associated thrombosis (CAT). Therefore, directing formation is a promising therapeutic strategy and related diseases. Diosmetin, an antioxidant flavonoid derived from dietary sources, might be involved CAT. Firstly, the tests cell-free DNA Immunofluorescence were applied to evaluate levels Luminol-based chemiluminescence DCFH-DA probe used detect reactive oxygen species (ROS) Then, network pharmacological analysis molecular docking predict potential target molecules diosmetin. The RT-qPCR was performed measure Nrf2 HO-1. A series functional assays neutrophils examine effect diosmetin on other neutrophil functions. Finally, animal model deep vein constructed assess thrombosis. Diosmetin reduced ROS mechanisms suggested that primary treatment increased HO-1 NETs-generating An inhibitor diminished negative generation. Lastly, murine results indicated via formation. exerts as anti-NETs through signaling neutrophils, showing thromboembolism pathological processes, such

Язык: Английский

Процитировано

0
Pain management in cancer patients – Could opioids or NSAIDs influence outcomes? DOI Creative Commons
Laura Smith,

A Lal,

Patrice Forget

и другие.

Best Practice & Research Clinical Anaesthesiology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
The role of neutrophils in osteosarcoma: insights from laboratory to clinic DOI Creative Commons
Ming Xia, Yu Han,

Lihui Sun

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 8, 2024

Osteosarcoma, a highly aggressive malignant bone tumor, is significantly influenced by the intricate interactions within its tumor microenvironment (TME), particularly involving neutrophils. This review delineates multifaceted roles of neutrophils, including tumor-associated neutrophils (TANs) and neutrophil extracellular traps (NETs), in osteosarcoma’s pathogenesis. TANs exhibit both pro- anti-tumor phenotypes, modulating growth immune evasion, while NETs facilitate cell adhesion, migration, immunosuppression. Clinically, neutrophil-related markers such as neutrophil-to-lymphocyte ratio (NLR) predict patient outcomes, highlighting potential for neutrophil-targeted therapies. Unraveling these complex crucial developing novel treatment strategies that harness TME to improve osteosarcoma management.

Язык: Английский

Процитировано

0