A review of the effects of different types of social behaviors on the recruitment of neuropeptides and neurotransmitters in the nucleus accumbens

Frontiers in Neuroendocrinology, Год журнала: 2025, Номер unknown, С. 101175 - 101175

Опубликована: Янв. 1, 2025

Язык: Английский

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Hormonal contraceptives during adolescence impact the female brain and behavior in a rat model

Hormones and Behavior, Год журнала: 2025, Номер 171, С. 105725 - 105725

Опубликована: Апрель 6, 2025

Millions of people take hormonal contraceptives (HCs), often starting during adolescence when ovarian hormones influence brain and behavioral maturation. However, there is a fundamental lack information about the neurobehavioral consequences alterations via adolescent HC use. To begin addressing this gap, we validated rodent model administration characterized its impact on endocrine, transcriptional, endpoints. Cohorts intact post-pubertal female Sprague-Dawley rats received daily subcutaneous injections either vehicle or [10 μg ethinyl estradiol (EE) + 20 levonorgestrel (LNG)] for duration from postnatal day (PND) 35 to PND56. Blood tissue was collected at PND57. Other cohorts PND35 until assays were completed PND57-64. treatment effective, as vaginal lavage indicated disrupted estrous cycling ELISA suppressed serum luteinizing hormone in HC-treated rats. Liquid chromatography-mass spectrometry analysis showed EE LNG well diminished levels allopregnanolone testosterone NanoString nCounter that impacted expression genes related synapses, white matter, neuroimmune, monoamine, signaling hypothalamus medial prefrontal cortex. While no effects HCs seen sociability social preference test stress coping behavior forced swim test, risk-assessment behaviors novelty-induced hypophagia paradigm altered anxiety-like open field elevated plus maze. Overall, these data suggest exposure contraceptive critical developmental period may shape behavior.

Язык: Английский

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The medial amygdala’s neural circuitry: Insights into social processing and sex differences

Frontiers in Neuroendocrinology, Год журнала: 2025, Номер unknown, С. 101190 - 101190

Опубликована: Апрель 1, 2025

Язык: Английский

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Peripartum buprenorphine and oxycodone exposure impair maternal behavior and increase neuroinflammation in the brains of new mother rats

Brain Behavior and Immunity, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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Evidence for the contribution of vasopressin V1B receptors in the pathophysiology of depression

Biochemical Pharmacology, Год журнала: 2024, Номер 231, С. 116672 - 116672

Опубликована: Ноя. 26, 2024

Язык: Английский

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Immune-regulating effect of oxytocin and its association with the hypothalamic-pituitary axes

Journal of Neuroimmunology, Год журнала: 2024, Номер 394, С. 578419 - 578419

Опубликована: Июль 27, 2024

Язык: Английский

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SHANK3 and olfaction; spatial atlas of mouse brain; persistence of autism diagnoses

The Transmitter, Год журнала: 2023, Номер unknown

Опубликована: Янв. 1, 2023

Язык: Английский

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