Progress in the study of the mechanism of ferroptosis in coronary heart disease and clinical intervention strategies DOI Creative Commons
Yingzhi Liu, Zixuan Yu,

Yuwen Lu

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 16, 2025

Coronary heart disease (CHD), a serious cardiovascular condition with complex and diverse pathogenesis, has recently seen increased attention to the role of ferroptosis—a novel iron-dependent form programmed cell death. This review synthesizes current research on ferroptosis mechanisms in CHD emerging clinical intervention strategies. Ferroptosis is characterized by dysregulated iron metabolism, lipid peroxidation, reactive oxygen species (ROS) accumulation, processes intimately linked pathophysiology. Under ischemic hypoxic conditions commonly coronary artery (CAD), cardiomyocytes become particularly susceptible ferroptosis, resulting cellular dysfunction diminished cardiac performance. Mechanistic studies have revealed that altered expression metabolism-related proteins (including GPX4, FTH1, TfR1, HO-1), accumulation peroxidation products, disruption antioxidant defense systems (particularly Nrf2/GPX4 pathway) are central progression tissue. Clinically, both specific inhibitors (such as Ferrostatin-1) traditional medicine components Puerarin) emerged promising therapeutic candidates, showing cardioprotective effects experimental models. However, into remains its early stages, significant questions regarding relationship other death pathways efficacy ferroptosis-targeting interventions requiring further investigation. Future directions should include in-depth mechanistic exploration development more effective, safer targeting pathway disease.

Язык: Английский

Progress in the study of the mechanism of ferroptosis in coronary heart disease and clinical intervention strategies DOI Creative Commons
Yingzhi Liu, Zixuan Yu,

Yuwen Lu

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 16, 2025

Coronary heart disease (CHD), a serious cardiovascular condition with complex and diverse pathogenesis, has recently seen increased attention to the role of ferroptosis—a novel iron-dependent form programmed cell death. This review synthesizes current research on ferroptosis mechanisms in CHD emerging clinical intervention strategies. Ferroptosis is characterized by dysregulated iron metabolism, lipid peroxidation, reactive oxygen species (ROS) accumulation, processes intimately linked pathophysiology. Under ischemic hypoxic conditions commonly coronary artery (CAD), cardiomyocytes become particularly susceptible ferroptosis, resulting cellular dysfunction diminished cardiac performance. Mechanistic studies have revealed that altered expression metabolism-related proteins (including GPX4, FTH1, TfR1, HO-1), accumulation peroxidation products, disruption antioxidant defense systems (particularly Nrf2/GPX4 pathway) are central progression tissue. Clinically, both specific inhibitors (such as Ferrostatin-1) traditional medicine components Puerarin) emerged promising therapeutic candidates, showing cardioprotective effects experimental models. However, into remains its early stages, significant questions regarding relationship other death pathways efficacy ferroptosis-targeting interventions requiring further investigation. Future directions should include in-depth mechanistic exploration development more effective, safer targeting pathway disease.

Язык: Английский

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