Macrophage senescence in health and diseases

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(4), С. 1508 - 1524

Опубликована: Янв. 20, 2024

Macrophage senescence, manifested by the special form of durable cell cycle arrest and chronic low-grade inflammation like senescence-associated secretory phenotype, has long been considered harmful. Persistent senescence macrophages may lead to maladaptation, immune dysfunction, finally development age-related diseases, infections, autoimmune malignancies. However, it is a ubiquitous, multi-factorial, dynamic complex phenomenon that also plays roles in remodeled processes, including wound repair embryogenesis. In this review, we summarize some general molecular changes several specific biomarkers during macrophage which bring new sight recognize senescent different conditions. Also, take an in-depth look at functional macrophages, metabolism, autophagy, polarization, phagocytosis, antigen presentation, infiltration or recruitment. Furthermore, degenerations diseases associated with as well mechanisms relevant genetic regulations are integrated, not only emphasizing possibility regulating benefit age-associated but implication on finding potential targets drugs clinically.

Язык: Английский

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Spermidine‐Functionalized Injectable Hydrogel Reduces Inflammation and Enhances Healing of Acute and Diabetic Wounds In Situ

Advanced Science, Год журнала: 2024, Номер 11(22)

Опубликована: Апрель 11, 2024

Abstract The inflammatory response is a key factor affecting tissue regeneration. Inspired by the immunomodulatory role of spermidine, an injectable double network hydrogel functionalized with spermidine (DN‐SPD) developed, where first and second networks are formed dynamic imine bonds non‐dynamic photo‐crosslinked respectively. single before photo‐crosslinking exhibits excellent injectability thus can be printed in situ to form hydrogels. DN‐SPD has demonstrated desirable mechanical properties adhesion. More importantly, “operando” comparison hydrogels loaded or diethylenetriamine (DETA), sham molecule resembling shown similar physical properties, but quite different biological functions. Specifically, outcomes 3 sets vivo animal experiments demonstrate that not only reduce inflammation caused implanted exogenous biomaterials reactive oxygen species also promote polarization macrophages toward regenerative M2 phenotype, DN‐DETA hydrogel. Moreover, immunoregulation translate into faster more natural healing both acute wounds diabetic wounds. Hence, local administration affords simple elegant approach attenuate foreign body reactions induced treat chronic refractory

Язык: Английский

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Chitosan‐Based Hydrogels as Antibacterial/Antioxidant/Anti‐Inflammation Multifunctional Dressings for Chronic Wound Healing

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(30)

Опубликована: Июль 22, 2024

Abstract Due to repeated microbial infection, persistent inflammation, excessive oxidative stress, and cell dysfunction, chronic wounds are difficult heal, posing a serious threat public health. Therefore, developing multifunctional wound dressings that can regulate the complex microenvironment of enhance cellular function holds great significance. Recently, chitosan has emerged as promising biopolymer for healing due its excellent biocompatibility, biodegradability, versatile bioactivity. The aim this review is provide comprehensive understanding mechanisms delayed discuss healing–promoting properties derivatives, such good antibacterial activity, hemostatic capacity, ability promote tissue regeneration. On basis, potential applications chitosan‐based hydrogels summarized in healing, including providing suitable microenvironment, eliminating bacterial infections, promoting hemostasis, inhibiting alleviating In addition, concerns perspectives clinical application also discussed.

Язык: Английский

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Recent advances of hydrogels as smart dressings for diabetic wounds

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(5), С. 1126 - 1148

Опубликована: Янв. 1, 2024

This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy diabetic wounds.

Язык: Английский

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Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Апрель 26, 2024

Wound healing is a tightly regulated process that ensures tissue repair and normal function following injury. It modulated by activation of pathways such as the transforming growth factor-beta (TGF-β), Notch, Wnt/β-catenin signaling pathways. Dysregulation this causes poor wound healing, which leads to fibrosis ulcerative wounds. The pathway involved in all phases primarily proliferative phase for formation granulation tissue. This review focuses on role its transcriptional regulation target genes. crosstalk between Wnt/β-catenin, TGF-β pathways, well deregulation chronic wounds are also considered, with special focus diabetic ulcers. Lastly, we discuss current prospective therapies wounds, primary strategies photobiomodulation

Язык: Английский

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Microenvironment-responsive smart hydrogels with antibacterial activity and immune regulation for accelerating chronic wound healing

Journal of Controlled Release, Год журнала: 2024, Номер 368, С. 518 - 532

Опубликована: Март 12, 2024

Язык: Английский

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Research progress of natural polysaccharide-based and natural protein-based hydrogels for bacteria-infected wound healing

Chemical Engineering Journal, Год журнала: 2024, Номер 496, С. 153803 - 153803

Опубликована: Июль 6, 2024

Язык: Английский

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The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds

Cellular & Molecular Biology Letters, Год журнала: 2024, Номер 29(1)

Опубликована: Фев. 5, 2024

Abstract Background Chronic nonhealing wounds remain a considerable challenge in clinical treatment due to excessive inflammation and impeded reepithelialization angiogenesis. Therefore, the discovery of novel prohealing agents for chronic skin are urgent important. Amphibian-derived peptides, especially immunomodulatory provide promising strategy trauma. However, mechanism peptides accelerating wound healing remains poorly understood. Methods The ability peptide Andersonin-W1 (AW1) was assessed by cell scratch, proliferation, transwell, tube formation. Next, full-thickness, deep second-degree burns diabetic full-thickness mice were performed detect therapeutic effects AW1. Moreover, tissue regeneration expression inflammatory cytokines evaluated hematoxylin eosin (H&E), enzyme-linked immunosorbent assay (ELISA), immunohistochemistry staining. Molecular docking, colocalization, western blotting used explore AW1 promoting healing. Results We solid evidence display excellent AW1, identified as short antimicrobial our previous report. At relative low concentration nM, promoted migration, scratch repair keratinocyte, macrophage formation HUVEC. also facilitated reepithelialization, granulation regeneration, angiogenesis, thus significantly boosting mice. Mechanistically, macrophages, directly bound Toll-like receptor 4 (TLR4) extracellular region regulated downstream nuclear factor‐κB (NF-κB) signaling pathway facilitate factor secretion suppress induced lipopolysaccharide (LPS). polarization promote transition from proliferative phase then exhibiting on wounds. Conclusions modulates process TLR4/NF-κB molecular axis, facilitating These findings not only provided multifunctional drug candidate but highlighted unique roles “small” elucidation “big” human disease mechanisms. Graphical

Язык: Английский

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Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing

Bioactive Materials, Год журнала: 2024, Номер 44, С. 131 - 151

Опубликована: Окт. 15, 2024

Язык: Английский

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Human Keratinocyte-Derived Exosomal MALAT1 Promotes Diabetic Wound Healing by Upregulating MFGE8 via microRNA-1914-3p

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 949 - 970

Опубликована: Фев. 1, 2023

Purpose: Diabetic wound is a highly prevalent and refractory disease. Extensive studies have confirmed that keratinocytes macrophages play an important role in the process of healing. Additionally, exosomes are regarded as vital intercellular communication tool. This study aimed to investigate human keratinocyte-derived exosomal MALAT1 treatment diabetic by influencing biological function macrophages. Methods: We mainly assessed on changes macrophages, expression keratinocyte-exosomes analyzed quantitative real-time polymerase chain reaction (RT-qPCR). The downstream interaction between RNAs or proteins was mechanistic experiments. Besides, we evaluated effects healing vivo verify vitro results. Results: demonstrated enhanced functions high glucose-injured including phagocytosis, converting pro-healing phenotype reducing apoptosis. Mechanistically, accelerated MFGE8 competitively binding miR-1914-3p, thereby affecting signal axis TGFB1/SMAD3, finally promoting wounds. Human might promote collagen deposition, ECM remodeling, MFGE8, VEGF, CD31 but reduce TGFB SMAD3 model mice wounds, which restored its function. Conclusion: current revealed would suppress miR-1914-3p activate eventually enhancing macrophage It proposed capacity serve new method for clinical wound. Graphical Abstract: Keywords: exosomes, keratinocytes, MALAT1,

Язык: Английский

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