Multifunctional Nanomedicine for Targeted Atherosclerosis Therapy: Activating Plaque Clearance Cascade and Suppressing Inflammation

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Atherosclerosis (AS) is a prevalent inflammatory vascular disease characterized by plaque formation, primarily composed of foam cells laden with lipids. Despite lipid-lowering therapies, effective clearance remains challenging due to the overexpression CD47 molecule on apoptotic cells, inhibiting macrophage-mediated cellular efferocytosis and resolution. Moreover, AS lesions are often associated severe inflammation oxidative stress, exacerbating progression. Herein, we introduce multifunctional nanomedicine (CEZP) targeting pathogenesis via "cell efferocytosis–lipid degradation–cholesterol efflux" paradigm, additional anti-inflammatory properties. CEZP comprises poly(lactic-co-glycolic acid) nanoparticles encapsulated within metal–organic framework shell coordinated zinc ions (Zn2+) epigallocatechin gallate (EGCG), enabling CpG encapsulation. Upon intravenous administration, accumulates at sites, facilitating macrophage uptake orchestrating treatment through synergistic mechanisms. enhances efferocytosis, Zn2+ promotes intracellular lipid degradation, EGCG upregulates adenosine 5′-triphosphate-binding cassette transporters for cholesterol efflux while also exhibiting antioxidant effects. In vivo validation confirms CEZP's ability stabilize plaques, reduce burden, modulate phenotype. excreted from body without safety concerns, offering low-toxicity nonsurgical strategy eradication.

Язык: Английский

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Lipocalin family proteins and their diverse roles in cardiovascular disease

Pharmacology & Therapeutics, Год журнала: 2023, Номер 244, С. 108385 - 108385

Опубликована: Март 24, 2023

Язык: Английский

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​Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarction

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Апрель 30, 2024

Ischemic heart disease is one of the leading causes mortality worldwide, and thus calls for development more effective therapeutic strategies. This study aimed to identify potential targets coronary (CHD) myocardial infarction (MI) by investigating causal relationship between plasma proteins these conditions.

Язык: Английский

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Peptide‐Based Supramolecular Therapeutics for Fighting Major Diseases

Advanced Functional Materials, Год журнала: 2024, Номер 34(25)

Опубликована: Фев. 21, 2024

Abstract Peptide‐based supramolecular therapeutics (PST) refer to those theranostic nanomedicines based on peptide or derivatives self‐assembly that are constructed in vitro vivo. Benefiting from the inherent advantages of peptides, such as good biocompatibility, high bioactivity, and flexible tunability, reported PST have shown excellent application prospects combating many major diseases including cancer, cardiovascular disease, infectious autoimmune metabolic so on. Through thoughtful design, can be fabricated various forms, self‐assembled precursor molecules, functional nano‐assemblies, macroscopic large‐scale hydrogels. The involved peptides play different roles, serving drug carriers for effective delivery, acting scaffold materials cell culture, functioning bioactive sequences treating diseases. In this review, a comprehensive overview traditional strategies is provided build emphasize their therapeutic applications fighting pose threat human life health. Moreover, main challenges systems application, clinical translation also briefly discussed. It hoped review arouse much more attention paid promote its practical biomedical field.

Язык: Английский

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Use of Poly Lactic-co-glycolic Acid Nano and Micro Particles in the Delivery of Drugs Modulating Different Phases of Inflammation

Pharmaceutics, Год журнала: 2023, Номер 15(6), С. 1772 - 1772

Опубликована: Июнь 20, 2023

Chronic inflammation contributes to the pathogenesis of many diseases, including apparently unrelated conditions such as metabolic disorders, cardiovascular neurodegenerative osteoporosis, and tumors, but use conventional anti-inflammatory drugs treat these diseases is generally not very effective given their adverse effects. In addition, some alternative medications, natural compounds, have scarce solubility stability, which are associated with low bioavailability. Therefore, encapsulation within nanoparticles (NPs) may represent an strategy enhance pharmacological properties bioactive molecules, poly lactic-co-glycolic acid (PLGA) NPs been widely used because high biocompatibility biodegradability possibility finely tune erosion time, hydrophilic/hydrophobic nature, mechanical by acting on polymer's composition preparation technique. Many studies focused PLGA-NPs deliver immunosuppressive treatments for autoimmune allergic or elicit protective immune responses, in vaccination cancer immunotherapy. By contrast, this review PLGA preclinical vivo models other a key role played chronic unbalance between reparative phases inflammation, particular focus intestinal bowel disease; cardiovascular, neurodegenerative, osteoarticular, ocular diseases; wound healing.

Язык: Английский

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Role of miR‐15a‐5p and miR‐199a‐3p in the inflammatory pathway regulated by NF‐κB in experimental and human atherosclerosis

Clinical and Translational Medicine, Год журнала: 2023, Номер 13(8)

Опубликована: Авг. 1, 2023

Abstract Background Cardiovascular diseases (CVDs) prevalence has significantly increased in the last decade and atherosclerosis development is main trigger. MicroRNAs (miRNAs) are non‐coding RNAs that negatively regulate gene expression of their target levels frequently altered CVDs. Methods By RT‐qPCR, we analysed miR‐9‐5p, miR‐15a‐5p, miR‐16‐5p miR‐199a‐3p aorta from apolipoprotein knockout ( ApoE −/− ) mice, an experimental model hyperlipidemia‐induced atherosclerosis, human aortic carotid atherosclerotic samples. silico studies, Western blot analysis immunofluorescence detected targets miRNAs. Results Our results show miR‐15a‐5p decreased samples patients mice with atherosclerosis. In addition, found both miRNAs participate inflammatory pathway nuclear factor kappa B (NF‐κB), such as IKKα, IKKβ p65. vein endothelial cells (HUVECs) vascular smooth muscle (VSMCs), overexpression or p65 protein well NF‐κB activation. On other hand, reduced ox‐LDL uptake inflammation regulated by VSMCs. Moreover, although were exosomes advanced only ROC analyses for area under curve was 0.8951 a p value .0028. Conclusions suggest decrease could be involved activation pathway, VSMCs, contributing to progression Finally, used novel diagnostic biomarker

Язык: Английский

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A Dual‐Targeting, Multi‐Faceted Biocompatible Nanodrug Optimizes the Microenvironment to Ameliorate Abdominal Aortic Aneurysm

Advanced Materials, Год журнала: 2024, Номер 36(33)

Опубликована: Июнь 24, 2024

Abdominal aortic aneurysm (AAA) is a highly lethal cardiovascular disease that currently lacks effective pharmacological treatment given the complex pathophysiology of disease. Here, single-cell RNA-sequencing data from patients with AAA and mouse model are analyzed, which reveals pivotal pathological changes, including M1-like polarization macrophages loss contractile function in smooth muscle cells (SMCs). Both cell types express integrin αvβ3, allowing for their dual targeting single rationally designed molecule. To this end, biocompatible nanodrug, termed EVMS@R-HNC, consists multifunctional drug everolimus (EVMS) encapsulated by hepatitis B virus core protein modifies to contain RGD sequence specifically bind αvβ3 designed. vitro vivo results show EVMS@R-HNC can target as well SMCs. Upon binding EVMS released intracellularly where it exhibits multiple functions, inhibiting M1 macrophage polarization, thereby suppressing self-propagating inflammatory cascade immune microenvironment imbalance, while preserving normal Collectively, these suggest presents promising therapeutic approach management AAA.

Язык: Английский

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Light-Responsive Functional Nanomaterials as Pioneering Therapeutics: A Paradigm Shift to Combat Age-Related Disorders

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(34), С. 8212 - 8234

Опубликована: Янв. 1, 2024

Aging, marked by dysregulated cellular systems, gives rise to a spectrum of age-related disorders, including neurodegeneration, atherosclerosis, immunosenescence, and musculoskeletal issues. These conditions contribute significantly the global disease burden, posing challenges health span economic resources. Current therapeutic approaches, although diverse in mechanism, often fall short targeting underlying pathologies. They fail address issues compounded altered pharmacokinetics elderly. Nanotechnology emerges as transformative solution, offering tissue-specific targeted therapies through nanoparticles. Functional nanomaterials (FNMs) respond internal or external stimuli, with light-responsive gaining prominence. Harnessing benefits deep tissue penetration ease manipulation particularly near-infrared spectrum, FNMs present innovative strategies for comorbidities. This review comprehensively summarizes potential FNM-based approaches environments also emphasizes advantages over traditional treatment modalities. Specifically, it focuses on development various classes functional plasmonic nanomaterials, carriers, upconversion 2D transition metal oxide dichalcogenide carbon-based against age related diseases. We foresee that such advanced developments field nanotechnology could provide new hope clinical diagnosis disorders.

Язык: Английский

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A Pharmacological Review of Tanshinones, Naturally Occurring Monomers from Salvia miltiorrhiza for the Treatment of Cardiovascular Diseases

Oxidative Medicine and Cellular Longevity, Год журнала: 2023, Номер 2023, С. 1 - 24

Опубликована: Фев. 6, 2023

Cardiovascular diseases (CVDs) are a set of heart and blood vessel disorders that include coronary disease (CHD), rheumatic disease, other conditions. Traditional Chinese Medicine (TCM) has definite effects on CVDs due to its multitarget multicomponent properties, which gradually gaining national attention. Tanshinones, the major active chemical compounds extracted from Salvia miltiorrhiza, exhibit beneficial improvement multiple diseases, especially CVDs. At level biological activities, they play significant roles, including anti-inflammation, anti-oxidation, anti-apoptosis anti-necroptosis, anti-hypertrophy, vasodilation, angiogenesis, combat against proliferation migration smooth muscle cells (SMCs), as well anti-myocardial fibrosis ventricular remodeling, all effective strategies in preventing treating Additionally, at cellular level, Tanshinones produce marked cardiomyocytes, macrophages, endothelia, SMCs, fibroblasts myocardia. In this review, we have summarized brief overview structures pharmacological CVD treatment expound different properties various cell types

Язык: Английский

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Recent advances in three-dimensional printing in cardiovascular devices: Bench and bedside applications

Smart Materials in Medicine, Год журнала: 2023, Номер 5(1), С. 36 - 51

Опубликована: Июль 17, 2023

Three-dimensional (3D) printing is emerging as an innovative technology, which widely used in cardiovascular disease at bench and bedside. During the last decade, with development of 3D industry, many printed models have been clinic, because it can provide advantage haptic feedback, direct manipulation, enhanced doctors' understanding anatomy underlying pathologies. In addition to preparation models, technology also shows great application potential regenerative medicine has advantages integrating cells, cytokines materials. Although still a gap between bedside, this gradually narrowing new materials recently. review, we firstly analyze characteristics clinical needs diseases, introduce concept category technology. Secondly, summarize stents, vascular graft, network, heart organs end, discuss challenges future perspectives diseases.

Язык: Английский

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