Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
Abstract
Oxidative
stress
leads
to
intestinal
barrier
damage,
which
induces
immune
responses
occur
and
further
promotes
oxidative
exacerbating
inflammatory
bowel
disease
(IBD).
In
this
work,
the
multifunctional
Zn
x
Ce
y
O
2
/Se
(ZCSO)
nanozyme
wrapped
with
acid‐resistant
calcium
alginate
hydrogel
designed
for
oral
administration
is
prepared.
The
ZCSO
can
promote
activation
of
Nrf2
pathway,
then
significantly
improve
efficiency
scavenging
reactive
oxygen
species
(ROS)
up‐regulate
protein
expression
glutathione
peroxidase
4
(GPx4),
closely
related
inhibition
ferroptosis.
addition,
inhibiting
growth
some
pathogenic
bacteria
proliferating
due
shows
a
positive
regulation
flora
reduces
secretion
pro‐inflammatory
factors
levels
macrophages,
achieving
significant
preventive
delayed
therapeutic
effect
colitis
mice.
Consequently,
distinctive
properties
render
it
promising
candidate
treatment
IBD
by
effectively
ROS,
thereby
interrupting
detrimental
cycle
between
response,
ultimately
promoting
proliferation
epithelial
cells
reestablish
integrity
mucosal
barrier.
Oral
medication
for
ulcerative
colitis
(UC)
is
often
hindered
by
challenges
such
as
inadequate
accumulation,
limited
penetration
of
mucus
barriers,
and
the
intricate
task
mitigating
excessive
ROS
inflammatory
cytokines.
Here,
we
present
a
strategy
involving
sodium
alginate
microspheres
(SAMs)
incorporating
M2
macrophage
membrane
(M2M)-coated
Janus
nanomotors
(denominated
Motor@M2M)
targeted
treatment
UC.
SAM
provides
protective
barrier,
ensuring
that
Motor@M2M
withstands
harsh
gastric
milieu
exhibits
controlled
release.
M2M
enhances
targeting
precision
to
tissues
acts
decoy
neutralization
Catalytic
decomposition
H
Abstract
Inflammatory
bowel
disease
(IBD)
is
a
recurring
chronic
inflammatory
disease.
Current
treatment
strategies
are
aimed
at
alleviating
clinical
symptoms
and
associated
with
gastrointestinal
or
systemic
adverse
effects.
New
delivery
needed
for
the
of
IBD.
Bacteria
promising
biocarriers,
which
can
produce
drugs
in
situ
sense
gut
real
time.
Herein,
we
focus
on
recent
studies
engineered
bacteria
used
IBD
introduce
application
diagnosis.
On
this
basis,
current
dilemmas
future
developments
bacterial
systems
discussed.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(22), С. 26298 - 26315
Опубликована: Май 26, 2023
Intestinal
immune
dysfunction
and
gut
microbiota
dysbiosis
are
critically
causative
factors
in
the
pathogenesis
of
ulcerative
colitis
(UC);
however,
current
first-line
drugs
for
UC
treatment
clinics
often
remain
great
challenges
due
to
their
nontargeting
therapeutic
efficacy
severe
side
effects.
In
study,
colon-targeting
nanoparticles
based
on
Angelica
sinensis
polysaccharide
with
pH-
redox-responsiveness
were
fabricated
specifically
release
naturally
active
compound
ginsenoside
Rh2
colonic
inflammatory
site,
which
greatly
alleviated
symptoms
improved
microbial
homeostasis.
These
dual
responsive
Rh2-loaded
(Rh2/LA-UASP
NPs)
a
particle
size
117.00
±
4.80
nm
prepared
using
polymer
LA-UASP
obtained
by
grafting
A.
urocanic
acid
α-lipoic
(α-LA).
As
expected,
these
Rh2/LA-UASP
NPs
achieved
redox-responsive
drug
at
pH
5.5
10
mM
GSH.
The
stability,
biocompatibility,
vivo
safety
experiments
exhibited
had
excellent
ability
significant
accumulation
colon.
Meanwhile,
could
escape
from
lysosomes
be
efficiently
internalized
into
intestinal
mucosal
cells,
thereby
effectively
inhibiting
proinflammatory
cytokines.
animal
indicated
that
significantly
integrity
mucosa
increased
colon
length
compared
mice.
Additionally,
weight
loss,
histological
damage,
inflammation
level
ameliorated.
homeostasis
flora
short-chain
fatty
acids
(SCFAs)
after
being
treated
Our
study
proved
pH-and
promising
candidates
treatment.
ACS Nano,
Год журнала:
2024,
Номер
18(19), С. 12117 - 12133
Опубликована: Апрель 22, 2024
Ulcerative
colitis
is
a
chronic
condition
in
which
dysregulated
immune
response
contributes
to
the
acute
intestinal
inflammation
of
colon.
Current
clinical
therapies
often
exhibit
limited
efficacy
and
undesirable
side
effects.
Here,
programmable
nanomicelles
were
designed
for
treatment
loaded
with
RU.521,
an
inhibitor
cyclic
GMP-AMP
synthase-stimulator
interferon
genes
(cGAS-STING)
pathway.
STING-inhibiting
micelles
(SIMs)
comprise
hyaluronic
acid-stearic
acid
conjugates
include
reactive
oxygen
species
(ROS)-responsive
thioketal
linker.
SIMs
selectively
accumulate
at
site
trigger
drug
release
presence
ROS.
Our
vitro
studies
macrophages
vivo
murine
model
demonstrated
that
leverage
HA-CD44
binding
target
sites
inflammation.
Oral
delivery
mice
both
preventive
delayed
therapeutic
models
ameliorated
colitis's
severity
by
reducing
STING
expression,
suppressing
secretion
proinflammatory
cytokines,
enabling
bodyweight
recovery,
protecting
from
colon
shortening,
restoring
colonic
epithelium.
In
end
points
combined
metabolomics
identified
key
metabolites
role
mucosal
findings
highlight
significance
platforms
downregulate
inflammatory
pathways
mucosa
managing
bowel
diseases.
Biomacromolecules,
Год журнала:
2023,
Номер
24(5), С. 2250 - 2263
Опубликована: Апрель 17, 2023
The
pathogenesis
of
inflammatory
bowel
diseases
(IBDs)
including
ulcerative
colitis
(UC)
and
Crohn's
disease
is
extremely
cloudy.
Maintaining
the
level
remission
lesions
in
default
treatment
attitude
at
present.
Epithelial
barrier
restoration
considered
as
same
important
strategy
colonic
targeted
drug
delivery
UC
treatment.
In
this
paper,
we
developed
a
multilayer
natural
polysaccharide
microsphere
(pectin/chitosan/alginate)
with
pH
enzyme
dual
sensitivity
to
reduce
loss
medication
upper
digestive
tract
preferentially
adhere
exposed
epithelial
cells
tissues
by
electrostatic
forces
for
efficiently
Olsalazine
an
was
loaded
chitosan
layer
realized
pH-responsive
release.
Furthermore,
microspheres
exhibited
excellent
capability
suppressing
harmful
flora
bio-adhesion
effect
extend
duration
local
medicine.
vivo
anti-colitis
study,
downregulated
levels
pro-inflammatory
factors
increase
tight
junction
protein
indicated
anti-inflammation
olsalazine-loaded
microspheres.
summary,
these
results
showed
that
could
be
powerful
candidate
system
therapy.
Molecular Nutrition & Food Research,
Год журнала:
2023,
Номер
68(2)
Опубликована: Ноя. 27, 2023
Ulcerative
colitis
(UC)
is
a
classic
inflammatory
bowel
disease
(IBD)
that
represents
serious
threat
to
human
health.
As
natural
flavonoid
with
multiple
biological
activities,
quercetin
(QCT)
suffers
from
low
bioavailability
through
limitations
in
chemical
stability.
Here,
the
study
investigates
regulatory
effects
of
nanoparticles
(QCT
NPs)
on
dextran
sulfate
sodium
(DSS)
induced
mice.
Journal of Materials Chemistry B,
Год журнала:
2023,
Номер
12(1), С. 13 - 38
Опубликована: Ноя. 29, 2023
Inflammatory
bowel
disease
(IBD)
is
a
chronic
and
idiopathic
condition
that
results
in
inflammation
of
the
gastrointestinal
tract,
leading
to
conditions
such
as
ulcerative
colitis
Crohn's
disease.