Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis

Science Advances, Год журнала: 2024, Номер 10(26)

Опубликована: Июнь 28, 2024

Oral medication for ulcerative colitis (UC) is often hindered by challenges such as inadequate accumulation, limited penetration of mucus barriers, and the intricate task mitigating excessive ROS inflammatory cytokines. Here, we present a strategy involving sodium alginate microspheres (SAMs) incorporating M2 macrophage membrane (M2M)-coated Janus nanomotors (denominated Motor@M2M) targeted treatment UC. SAM provides protective barrier, ensuring that Motor@M2M withstands harsh gastric milieu exhibits controlled release. M2M enhances targeting precision to tissues acts decoy neutralization Catalytic decomposition H

Язык: Английский

---

Recent advances in bacteria‐based platforms for inflammatory bowel diseases treatment

Exploration, Год журнала: 2024, Номер 4(5)

Опубликована: Март 5, 2024

Abstract Inflammatory bowel disease (IBD) is a recurring chronic inflammatory disease. Current treatment strategies are aimed at alleviating clinical symptoms and associated with gastrointestinal or systemic adverse effects. New delivery needed for the of IBD. Bacteria promising biocarriers, which can produce drugs in situ sense gut real time. Herein, we focus on recent studies engineered bacteria used IBD introduce application diagnosis. On this basis, current dilemmas future developments bacterial systems discussed.

Язык: Английский

---

Natural dietary ROS scavenger-based nanomaterials for ROS-related chronic disease prevention and treatment

Chemical Engineering Journal, Год журнала: 2024, Номер 490, С. 151756 - 151756

Опубликована: Апрель 30, 2024

Язык: Английский

---

Colon-Targeting Angelica sinensis Polysaccharide Nanoparticles with Dual Responsiveness for Alleviation of Ulcerative Colitis

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(22), С. 26298 - 26315

Опубликована: Май 26, 2023

Intestinal immune dysfunction and gut microbiota dysbiosis are critically causative factors in the pathogenesis of ulcerative colitis (UC); however, current first-line drugs for UC treatment clinics often remain great challenges due to their nontargeting therapeutic efficacy severe side effects. In study, colon-targeting nanoparticles based on Angelica sinensis polysaccharide with pH- redox-responsiveness were fabricated specifically release naturally active compound ginsenoside Rh2 colonic inflammatory site, which greatly alleviated symptoms improved microbial homeostasis. These dual responsive Rh2-loaded (Rh2/LA-UASP NPs) a particle size 117.00 ± 4.80 nm prepared using polymer LA-UASP obtained by grafting A. urocanic acid α-lipoic (α-LA). As expected, these Rh2/LA-UASP NPs achieved redox-responsive drug at pH 5.5 10 mM GSH. The stability, biocompatibility, vivo safety experiments exhibited had excellent ability significant accumulation colon. Meanwhile, could escape from lysosomes be efficiently internalized into intestinal mucosal cells, thereby effectively inhibiting proinflammatory cytokines. animal indicated that significantly integrity mucosa increased colon length compared mice. Additionally, weight loss, histological damage, inflammation level ameliorated. homeostasis flora short-chain fatty acids (SCFAs) after being treated Our study proved pH-and promising candidates treatment.

Язык: Английский

---

Nanotechnology-enabled M2 macrophage polarization and ferroptosis inhibition for targeted inflammatory bowel disease treatment

Journal of Controlled Release, Год журнала: 2024, Номер 367, С. 339 - 353

Опубликована: Фев. 1, 2024

Язык: Английский

---

Inhibiting the cGAS-STING Pathway in Ulcerative Colitis with Programmable Micelles

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12117 - 12133

Опубликована: Апрель 22, 2024

Ulcerative colitis is a chronic condition in which dysregulated immune response contributes to the acute intestinal inflammation of colon. Current clinical therapies often exhibit limited efficacy and undesirable side effects. Here, programmable nanomicelles were designed for treatment loaded with RU.521, an inhibitor cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway. STING-inhibiting micelles (SIMs) comprise hyaluronic acid-stearic acid conjugates include reactive oxygen species (ROS)-responsive thioketal linker. SIMs selectively accumulate at site trigger drug release presence ROS. Our vitro studies macrophages vivo murine model demonstrated that leverage HA-CD44 binding target sites inflammation. Oral delivery mice both preventive delayed therapeutic models ameliorated colitis's severity by reducing STING expression, suppressing secretion proinflammatory cytokines, enabling bodyweight recovery, protecting from colon shortening, restoring colonic epithelium. In end points combined metabolomics identified key metabolites role mucosal findings highlight significance platforms downregulate inflammatory pathways mucosa managing bowel diseases.

Язык: Английский

---

CaGA nanozymes inhibit oxidative stress and protect mitochondrial function in ulcerative colitis therapy

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

---

Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment

Biomacromolecules, Год журнала: 2023, Номер 24(5), С. 2250 - 2263

Опубликована: Апрель 17, 2023

The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy. Maintaining the level remission lesions in default treatment attitude at present. Epithelial barrier restoration considered as same important strategy colonic targeted drug delivery UC treatment. In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH enzyme dual sensitivity to reduce loss medication upper digestive tract preferentially adhere exposed epithelial cells tissues by electrostatic forces for efficiently Olsalazine an was loaded chitosan layer realized pH-responsive release. Furthermore, microspheres exhibited excellent capability suppressing harmful flora bio-adhesion effect extend duration local medicine. vivo anti-colitis study, downregulated levels pro-inflammatory factors increase tight junction protein indicated anti-inflammation olsalazine-loaded microspheres. summary, these results showed that could be powerful candidate system therapy.

Язык: Английский

---

pH Sensitive Quercetin Nanoparticles Ameliorate DSS‐Induced Colitis in Mice by Colon‐Specific Delivery

Molecular Nutrition & Food Research, Год журнала: 2023, Номер 68(2)

Опубликована: Ноя. 27, 2023

Ulcerative colitis (UC) is a classic inflammatory bowel disease (IBD) that represents serious threat to human health. As natural flavonoid with multiple biological activities, quercetin (QCT) suffers from low bioavailability through limitations in chemical stability. Here, the study investigates regulatory effects of nanoparticles (QCT NPs) on dextran sulfate sodium (DSS) induced mice.

Язык: Английский

---

Orally-administered nanomedicine systems targeting colon inflammation for the treatment of inflammatory bowel disease: latest advances

Journal of Materials Chemistry B, Год журнала: 2023, Номер 12(1), С. 13 - 38

Опубликована: Ноя. 29, 2023

Inflammatory bowel disease (IBD) is a chronic and idiopathic condition that results in inflammation of the gastrointestinal tract, leading to conditions such as ulcerative colitis Crohn's disease.

Язык: Английский

---