Exploring the Analgesic Potential of L-Lysine: Molecular Mechanisms, Preclinical Evidence, and Implications for Pharmaceutical Pain Therapy
Walaa Alibrahem,
Nihad Kharrat Helu,
Gréta Törős
и другие.
Pharmaceutics,
Год журнала:
2025,
Номер
17(5), С. 666 - 666
Опубликована: Май 19, 2025
Pain
is
a
complex,
multifaceted
sensory–emotional
state.
It
still
poses
significant
challenge
in
clinical
treatment,
especially
cases
of
chronic
pain.
Concerns
associated
with
the
use
opioids
as
analgesics
have
led
to
search
for
new
and
safer
pain
relievers.
This
review
examines
potential
lysine
control
by
exploring
its
molecular
mechanisms
preclinical
evidence
implications.
Lysine
has
demonstrated
analgesic
effects
inhibiting
NMDA
receptors,
modulating
dopamine
serotonin
pathways,
interfering
neuroimmune
signaling
cascades.
Studies
animal
models
shown
that
administration
reduces
responses
without
altering
motor
function.
Despite
favorable
profile
terms
minor
side
promising
effectiveness
nutritional
supplement,
more
research
needed
optimize
efficacy,
adjust
dosage,
ensure
safety
long-term
use.
Язык: Английский
Terpenoids: A Promising Traditional Chinese Medicine for Neuropathic Pain Relief
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107789 - 107789
Опубликована: Май 1, 2025
Язык: Английский
Bifunctionalized Betulinic Acid Conjugates with C-3-Monodesmoside and C-28-Triphenylphosphonium Moieties with Increased Cancer Cell Targetability
Journal of Natural Products,
Год журнала:
2023,
Номер
86(8), С. 1939 - 1949
Опубликована: Июль 27, 2023
A
convenient
synthesis
is
presented
for
a
new
class
of
bioactive
bifunctionalized
conjugates
lupane-type
triterpenoids
with
triphenylphosphonium
(TPP)
and
glycopyranosyl
targeting
moieties.
The
main
steps
include
glycosylation
haloalkyl
esters
the
triterpene
acid
at
C-3
position
by
imidate
derivatives
glycopyranose
followed
product
modification
C-28
triphenylphosphine.
betulinic
(BetA)
TPP
d-glucose,
l-rhamnose,
or
d-mannose
moieties
were
thus
synthesized
as
potential
next-generation
BetA-derived
anticancer
compounds.
LC-MS/MS
analysis
in
glucose-free
physiological
solution
indicated
that
glycosides
showed
better
accumulation
PC-3
prostate
cancer
cells
than
both
BetA
TPP–BetA
conjugate,
while
transporting
effect
monosaccharide
residues
increased
follows:
<
l-rhamnose
≈
d-glucose.
At
saturated
concentrations,
caused
disturbing
on
mitochondria
more
drastic
drop
transmembrane
but
weaker
overproduction
mitochondrial
reactive
oxygen
species
(ROS)
compared
to
conjugate.
Cytotoxicity
culture
medium
was
comparable
higher
nonglycosylated
depending
cell
line,
whereas
compounds
less
active
toward
primary
fibroblasts.
Glycosylation
tended
increase
pro-apoptotic
decrease
pro-autophagic
activities
derivatives.
considered
comparison
summarized
data
natural
modified
glycosides.
results
obtained
are
important
development
an
targetability.
Язык: Английский
Inhibition of N-type calcium channels by phenoxyaniline and sulfonamide analogues
RSC Medicinal Chemistry,
Год журнала:
2024,
Номер
15(3), С. 916 - 936
Опубликована: Янв. 1, 2024
A
detailed
SAR
study
led
to
two
potent
Ca
V
2.2
inhibitors,
the
sulfonamide
derivatives
42
and
45,
which
showed
high
plasma
stability,
low
toxicity,
favourable
CNS
MPO
scores
(4.0–4.4),
strong
potency.
Язык: Английский
Phytochemical Profiling and Antioxidant Activities of the Most Favored Ready-to-Use Thai Curries, Pad-Ka-Proa (Spicy Basil Leaves) and Massaman
Foods,
Год журнала:
2024,
Номер
13(4), С. 582 - 582
Опубликована: Фев. 14, 2024
Food
is
one
of
the
factors
with
highest
impact
on
human
health.
Today,
attention
paid
not
only
to
food
properties
such
as
energy
provision
and
palatability
but
also
functional
aspects
including
phytochemical,
antioxidant
properties,
etc.
Massaman
spicy
basil
leaf
curries
are
famous
Thai
dishes
a
good
harmony
flavor
taste,
derived
from
multiple
herbs
spices,
galangal
rhizomes,
chili
pods,
garlic
bulbs,
peppers,
shallots,
coriander
seeds,
that
provide
an
array
health
benefits.
The
characterization
phytochemicals
detected
by
LC-ESI-QTOF-MS/MS
identified
99
components
(Masaman)
62
(spicy
curry)
quininic
acid,
hydroxycinnamic
luteolin,
kaempferol,
catechin,
eugenol,
betulinic
gingerol.
cynaroside
luteolin-7-O-glucoside
found
in
curry
play
key
role
activities
were
at
significantly
higher
concentration
than
curry.
Phenolic
flavonoid
compounds
generally
exhibit
bitter
astringent
all
panelists
scored
both
7
out
9,
confirming
their
acceptable
flavor.
Results
suggest
leaves
contain
various
different
levels
may
be
further
used
ingredients
nutraceutical
products.
Язык: Английский
Simultaneous use of venlafaxine and calcium channel blockers on tolerance to morphine: The role of mitochondrial damage and oxidative stress in the brain
Pharmacology Biochemistry and Behavior,
Год журнала:
2024,
Номер
245, С. 173864 - 173864
Опубликована: Авг. 30, 2024
Язык: Английский
Regulation of pain neurotransmitters and chondrocytes metabolism mediated by voltage-gated ion channels: A narrative review
Heliyon,
Год журнала:
2023,
Номер
9(7), С. e17989 - e17989
Опубликована: Июль 1, 2023
Osteoarthritis
(OA)
is
one
of
the
leading
causes
chronic
pain
and
dysfunction.
It
essential
to
comprehend
nature
cartilage
degeneration
its
influencing
factors
on
OA
treatment.
Voltage-gated
ion
channels
(VGICs)
are
in
chondrocytes
extracellular
matrix
(ECM)
metabolism
regulate
neurotransmitters
between
central
nervous
system.
This
narrative
review
focused
primarily
effects
VGICs
regulating
metabolism,
most
studies
have
voltage-sensitive
calcium
(VSCCs),
voltage-gated
sodium
(VGSCs),
acid-sensing
(ASICs),
potassium
(VGKCs),
chloride
(VGCCs).
Various
coordinate
maintain
intracellular
environment's
homeostasis
jointly
metabolic
under
normal
circumstances.
In
model,
channel
transport
abnormal,
influx
increased,
which
leads
increased
neuronal
excitability.
The
changes
strongly
associated
with
disease
process
individual
risk
factors.
Future
should
explore
how
affect
their
surrounding
tissues,
will
help
clinicians
pharmacists
develop
more
effective
targeted
drugs
alleviate
progression
disease.
Язык: Английский
Ethanolic Extracts of Cissus quadrangularis Linn. (Vitaceae) Attenuate Vincristine‐Induced Peripheral Neuropathy in Rats: An Evidence of the Antioxidant, Calcium Inhibitory, and Neuromodulatory Properties
Advances in Pharmacological and Pharmaceutical Sciences,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Cissus
quadrangularis
Linn.
(
C.
,
Vitaceae)
is
a
plant
reported
to
treat
injured
tendons,
broken
bones,
asthma,
stomach
ache,
scurvy,
and
digestive
disorders.
The
present
study
evaluated
the
antihyperalgesic
effects
of
ethanolic
extract
Vincristine
sulfate
(100
μg/kg,
i.p.)
was
administered
in
rats
for
10
days
with
2
break
induce
painful
peripheral
neuropathy.
Mechanical
hyperalgesia
allodynia
tests
were
performed
assess
threshold
Calcium
levels
sciatic
nerve,
oxidant
stress
markers,
GABA
5‐HT
also
determined
brain
spinal
cord
after
15
days.
Ethanolic
(180
360
mg/kg)
pregabalin
(50
consecutive
results
revealed
that
significantly
p
<
0.001)
inhibited
animals
vincristine
administration.
decreased
total
calcium
MDA
while
increasing
GSH
activity,
level,
as
well
cord.
this
suggest
uses
antioxidant
capacity,
inhibitory
action,
neuromodulation
prevent
development
neuropathy
This
demonstrates
promising
molecule
management
neuropathic
pain
induced
by
anticancer
drugs.
Язык: Английский