Ethanolic Extracts of Cissus quadrangularis Linn. (Vitaceae) Attenuate Vincristine‐Induced Peripheral Neuropathy in Rats: An Evidence of the Antioxidant, Calcium Inhibitory, and Neuromodulatory Properties DOI Creative Commons

Feigni Youyi Marcelle Olga,

Marius Mbiantcha,

Yousseu Nana William

и другие.

Advances in Pharmacological and Pharmaceutical Sciences, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Cissus quadrangularis Linn. ( C. , Vitaceae) is a plant reported to treat injured tendons, broken bones, asthma, stomach ache, scurvy, and digestive disorders. The present study evaluated the antihyperalgesic effects of ethanolic extract Vincristine sulfate (100 μg/kg, i.p.) was administered in rats for 10 days with 2 break induce painful peripheral neuropathy. Mechanical hyperalgesia allodynia tests were performed assess threshold Calcium levels sciatic nerve, oxidant stress markers, GABA 5‐HT also determined brain spinal cord after 15 days. Ethanolic (180 360 mg/kg) pregabalin (50 consecutive results revealed that significantly p < 0.001) inhibited animals vincristine administration. decreased total calcium MDA while increasing GSH activity, level, as well cord. this suggest uses antioxidant capacity, inhibitory action, neuromodulation prevent development neuropathy This demonstrates promising molecule management neuropathic pain induced by anticancer drugs.

Язык: Английский

Exploring the Analgesic Potential of L-Lysine: Molecular Mechanisms, Preclinical Evidence, and Implications for Pharmaceutical Pain Therapy DOI Creative Commons

Walaa Alibrahem,

Nihad Kharrat Helu,

Gréta Törős

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(5), С. 666 - 666

Опубликована: Май 19, 2025

Pain is a complex, multifaceted sensory–emotional state. It still poses significant challenge in clinical treatment, especially cases of chronic pain. Concerns associated with the use opioids as analgesics have led to search for new and safer pain relievers. This review examines potential lysine control by exploring its molecular mechanisms preclinical evidence implications. Lysine has demonstrated analgesic effects inhibiting NMDA receptors, modulating dopamine serotonin pathways, interfering neuroimmune signaling cascades. Studies animal models shown that administration reduces responses without altering motor function. Despite favorable profile terms minor side promising effectiveness nutritional supplement, more research needed optimize efficacy, adjust dosage, ensure safety long-term use.

Язык: Английский

Процитировано

0

Terpenoids: A Promising Traditional Chinese Medicine for Neuropathic Pain Relief DOI Creative Commons

Hui-Si Yang,

David H. Mauki, Yiqing Zheng

и другие.

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107789 - 107789

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Bifunctionalized Betulinic Acid Conjugates with C-3-Monodesmoside and C-28-Triphenylphosphonium Moieties with Increased Cancer Cell Targetability DOI

Olga V. Tsepaeva,

Taliya I. Salikhova, Rezeda A. Ishkaeva

и другие.

Journal of Natural Products, Год журнала: 2023, Номер 86(8), С. 1939 - 1949

Опубликована: Июль 27, 2023

A convenient synthesis is presented for a new class of bioactive bifunctionalized conjugates lupane-type triterpenoids with triphenylphosphonium (TPP) and glycopyranosyl targeting moieties. The main steps include glycosylation haloalkyl esters the triterpene acid at C-3 position by imidate derivatives glycopyranose followed product modification C-28 triphenylphosphine. betulinic (BetA) TPP d-glucose, l-rhamnose, or d-mannose moieties were thus synthesized as potential next-generation BetA-derived anticancer compounds. LC-MS/MS analysis in glucose-free physiological solution indicated that glycosides showed better accumulation PC-3 prostate cancer cells than both BetA TPP–BetA conjugate, while transporting effect monosaccharide residues increased follows: < l-rhamnose ≈ d-glucose. At saturated concentrations, caused disturbing on mitochondria more drastic drop transmembrane but weaker overproduction mitochondrial reactive oxygen species (ROS) compared to conjugate. Cytotoxicity culture medium was comparable higher nonglycosylated depending cell line, whereas compounds less active toward primary fibroblasts. Glycosylation tended increase pro-apoptotic decrease pro-autophagic activities derivatives. considered comparison summarized data natural modified glycosides. results obtained are important development an targetability.

Язык: Английский

Процитировано

4

Inhibition of N-type calcium channels by phenoxyaniline and sulfonamide analogues DOI Creative Commons
Anjie S. Bispat, Fernanda C. Cardoso, Md. Mahadhi Hasan

и другие.

RSC Medicinal Chemistry, Год журнала: 2024, Номер 15(3), С. 916 - 936

Опубликована: Янв. 1, 2024

A detailed SAR study led to two potent Ca V 2.2 inhibitors, the sulfonamide derivatives 42 and 45, which showed high plasma stability, low toxicity, favourable CNS MPO scores (4.0–4.4), strong potency.

Язык: Английский

Процитировано

1

Phytochemical Profiling and Antioxidant Activities of the Most Favored Ready-to-Use Thai Curries, Pad-Ka-Proa (Spicy Basil Leaves) and Massaman DOI Creative Commons
Sunisa Siripongvutikorn,

Kanyamanee Pumethakul,

Chutha Takahashi Yupanqui

и другие.

Foods, Год журнала: 2024, Номер 13(4), С. 582 - 582

Опубликована: Фев. 14, 2024

Food is one of the factors with highest impact on human health. Today, attention paid not only to food properties such as energy provision and palatability but also functional aspects including phytochemical, antioxidant properties, etc. Massaman spicy basil leaf curries are famous Thai dishes a good harmony flavor taste, derived from multiple herbs spices, galangal rhizomes, chili pods, garlic bulbs, peppers, shallots, coriander seeds, that provide an array health benefits. The characterization phytochemicals detected by LC-ESI-QTOF-MS/MS identified 99 components (Masaman) 62 (spicy curry) quininic acid, hydroxycinnamic luteolin, kaempferol, catechin, eugenol, betulinic gingerol. cynaroside luteolin-7-O-glucoside found in curry play key role activities were at significantly higher concentration than curry. Phenolic flavonoid compounds generally exhibit bitter astringent all panelists scored both 7 out 9, confirming their acceptable flavor. Results suggest leaves contain various different levels may be further used ingredients nutraceutical products.

Язык: Английский

Процитировано

1

Simultaneous use of venlafaxine and calcium channel blockers on tolerance to morphine: The role of mitochondrial damage and oxidative stress in the brain DOI

Asma Soleimanii,

Faezeh Fallah, Behnam Ghorbanzadeh

и другие.

Pharmacology Biochemistry and Behavior, Год журнала: 2024, Номер 245, С. 173864 - 173864

Опубликована: Авг. 30, 2024

Язык: Английский

Процитировано

1

Regulation of pain neurotransmitters and chondrocytes metabolism mediated by voltage-gated ion channels: A narrative review DOI Creative Commons
Xinwei Wang, Xueping Li

Heliyon, Год журнала: 2023, Номер 9(7), С. e17989 - e17989

Опубликована: Июль 1, 2023

Osteoarthritis (OA) is one of the leading causes chronic pain and dysfunction. It essential to comprehend nature cartilage degeneration its influencing factors on OA treatment. Voltage-gated ion channels (VGICs) are in chondrocytes extracellular matrix (ECM) metabolism regulate neurotransmitters between central nervous system. This narrative review focused primarily effects VGICs regulating metabolism, most studies have voltage-sensitive calcium (VSCCs), voltage-gated sodium (VGSCs), acid-sensing (ASICs), potassium (VGKCs), chloride (VGCCs). Various coordinate maintain intracellular environment's homeostasis jointly metabolic under normal circumstances. In model, channel transport abnormal, influx increased, which leads increased neuronal excitability. The changes strongly associated with disease process individual risk factors. Future should explore how affect their surrounding tissues, will help clinicians pharmacists develop more effective targeted drugs alleviate progression disease.

Язык: Английский

Процитировано

3

Ethanolic Extracts of Cissus quadrangularis Linn. (Vitaceae) Attenuate Vincristine‐Induced Peripheral Neuropathy in Rats: An Evidence of the Antioxidant, Calcium Inhibitory, and Neuromodulatory Properties DOI Creative Commons

Feigni Youyi Marcelle Olga,

Marius Mbiantcha,

Yousseu Nana William

и другие.

Advances in Pharmacological and Pharmaceutical Sciences, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Cissus quadrangularis Linn. ( C. , Vitaceae) is a plant reported to treat injured tendons, broken bones, asthma, stomach ache, scurvy, and digestive disorders. The present study evaluated the antihyperalgesic effects of ethanolic extract Vincristine sulfate (100 μg/kg, i.p.) was administered in rats for 10 days with 2 break induce painful peripheral neuropathy. Mechanical hyperalgesia allodynia tests were performed assess threshold Calcium levels sciatic nerve, oxidant stress markers, GABA 5‐HT also determined brain spinal cord after 15 days. Ethanolic (180 360 mg/kg) pregabalin (50 consecutive results revealed that significantly p < 0.001) inhibited animals vincristine administration. decreased total calcium MDA while increasing GSH activity, level, as well cord. this suggest uses antioxidant capacity, inhibitory action, neuromodulation prevent development neuropathy This demonstrates promising molecule management neuropathic pain induced by anticancer drugs.

Язык: Английский

Процитировано

0