The role of androgens on experimental pain sensitivity: a systemic review and meta-analysis DOI Creative Commons

Elizabeth Wu-Chen,

Gourav Banerjee, Elise Requadt

и другие.

PAIN Reports, Год журнала: 2025, Номер 10(2), С. e1263 - e1263

Опубликована: Март 17, 2025

Abstract Animal studies have shown androgens, especially testosterone, may an analgesic effect on nociceptive behavior. However, it is unclear if this present in humans. This review and meta-analysis aim to summarize synthesize the role of androgens experimental pain sensitivity Studies were included they examined (1) relationships between sensitivity, (2) group differences androgen or levels, (3) interventions sensitivity. After a comprehensive search, 31 papers identified. When possible, meta-analyses performed. Most impact testosterone pain, only few focused other such as dehydroepiandrosterone sulfate. Overall, current data do not support adult men women with without chronic pain. In addition, Pearson correlations did find levels ratings heat stimulus (3 studies, n = 93, Z correlation coefficient −0.43, confidence intervals [−1.50, 0.64]) electrical thresholds (4 147, 0.24, [−0.10, 0.58]). Moreover, contradicting results found intervention that increased decreased levels. Thus, suggested be minor, even though there wide heterogeneity studies. Future should examine interaction hormones

Язык: Английский

Sex hormones and diseases of the nervous system DOI Open Access

Hyman M. Schipper

Brain medicine :, Год журнала: 2025, Номер unknown, С. 1 - 10

Опубликована: Фев. 18, 2025

The influence of gonadal hormones on neurological health and disease is a rapidly developing domain in fundamental clinical neuroscience. Sex hormones, directly or via their neurosteroid metabolites, impact monoaminergic, cholinergic, peptidergic neurotransmission play essential roles shaping brain organization function under normal pathological conditions. expression various disorders may be modified by hormonal fluctuations related to the menstrual cycle, pregnancy, menopause, oral contraceptive use. Understanding these interactions could lead targeted antihormonal therapies for diverse conditions, including but not limited catamenial epilepsy, Parkinson disease, acute intermittent porphyria.

Язык: Английский

Процитировано

0
The role of androgens on experimental pain sensitivity: a systemic review and meta-analysis DOI Creative Commons

Elizabeth Wu-Chen,

Gourav Banerjee, Elise Requadt

и другие.

PAIN Reports, Год журнала: 2025, Номер 10(2), С. e1263 - e1263

Опубликована: Март 17, 2025

Abstract Animal studies have shown androgens, especially testosterone, may an analgesic effect on nociceptive behavior. However, it is unclear if this present in humans. This review and meta-analysis aim to summarize synthesize the role of androgens experimental pain sensitivity Studies were included they examined (1) relationships between sensitivity, (2) group differences androgen or levels, (3) interventions sensitivity. After a comprehensive search, 31 papers identified. When possible, meta-analyses performed. Most impact testosterone pain, only few focused other such as dehydroepiandrosterone sulfate. Overall, current data do not support adult men women with without chronic pain. In addition, Pearson correlations did find levels ratings heat stimulus (3 studies, n = 93, Z correlation coefficient −0.43, confidence intervals [−1.50, 0.64]) electrical thresholds (4 147, 0.24, [−0.10, 0.58]). Moreover, contradicting results found intervention that increased decreased levels. Thus, suggested be minor, even though there wide heterogeneity studies. Future should examine interaction hormones

Язык: Английский

Процитировано

0