Chronic paternal alcohol exposures induce dose-dependent changes in offspring craniofacial shape and symmetry DOI Creative Commons
Samantha Higgins, Sanat S. Bhadsavle,

Matthew N. Gaytan

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Июль 1, 2024

Although dose-response analyses are a fundamental tool in developmental toxicology, few studies have examined the impacts of toxicant dose on non-genetic paternal inheritance offspring disease and dysgenesis. In this study, we used geometric morphometric to examine different levels preconception alcohol exposure craniofacial shape symmetry mouse model. Procrustes ANOVA followed by canonical variant analysis facial relationships revealed that Low-, Medium-, High-dose treatments each induced distinct changes symmetry. Our identified threshold between 1.543 2.321 g/kg/day. Below threshold, shape, including right shift features. contrast, above exposures caused shifts both center, disrupting Consistent with previous clinical studies, predominantly mapped regions lower portion face, mandible (lower jaw) maxilla (upper jaw). Notably, high-dose also impacted positioning eye. reveal use may be an unrecognized factor contributing incidence severity alcohol-related defects, complicating diagnostics fetal spectrum disorders.

Язык: Английский

Maternal, Paternal, and Dual-Parental Alcohol Exposures Result in Both Overlapping and Distinct Impacts on Behavior in Adolescent Offspring DOI
Kara N. Thomas, Alison Basel,

H. Joseph Reitz

и другие.

Alcohol, Год журнала: 2025, Номер 124, С. 65 - 77

Опубликована: Янв. 22, 2025

Язык: Английский

Процитировано

0
Preconception Paternal Alcohol Consumption Elicits Postnatal Changes in Neural Retinas of the Offspring DOI Creative Commons

Kofi Owusu-Ansah,

Kara N. Thomas,

Kelsey Cox

и другие.

Investigative Ophthalmology & Visual Science, Год журнала: 2025, Номер 66(2), С. 16 - 16

Опубликована: Фев. 6, 2025

Purpose: This study aims to determine the impact of preconception paternal alcohol consumption (PPAC) on retinal function and morphology in PPAC-offspring. Fetal spectrum disorder (FASD)–related ocular defects caused by maternal exposure has been well investigated, but influence PPAC offspring eyes remains unknown. Methods: Adult C57BL/6J male mice were exposed either 10% ethanol or water (control) for six weeks bred naïve females. Dark-adapted light responses at two, four, months old assessed using electroretinography (ERG) born control males. The thicknesses whole retinas different layers PPAC-offspring analyzed two old. Results: Some had only one developed eye. ERG a- b-wave amplitudes reduced compared controls, with a more pronounced effect significant effects inner function. At old, there was thinning nuclear plexiform thickness similar between both treatment groups. Conclusions: provides pioneering evidence that contributes FASD-related including negative impacts young adult offspring. Thus adverse prior conception their (from childhood early adulthood) should be considered as seriously contribution FASD.

Язык: Английский

Процитировано

0
Parental Alcohol Exposures Associate with Lasting Mitochondrial Dysfunction and Accelerated Aging in a Mouse Model DOI Creative Commons
Alison Basel, Sanat S. Bhadsavle,

Katherine Z. Scaturro

и другие.

Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2024

Although detrimental changes in mitochondrial morphology and function are widely described symptoms of fetal alcohol exposure, no studies have followed these deficits into adult life or determined if they predispose individuals with spectrum disorders (FASDs) to accelerated biological aging. Here, we used a multiplex preclinical mouse model compare markers cellular senescence age-related outcomes induced by maternal, paternal, dual-parental exposures. We find that even middle (postnatal day 300), the offspring alcohol-exposed parents exhibited significant increases stress-induced premature brain liver, including an upregulation cell cycle inhibitory proteins increased senescence-associated β-galactosidase activity. Strikingly, male offspring, observe interaction between maternal paternal use, histological indicators liver disease exceeding those either use alone. Our indicate chronic parental causes enduring dysfunction resulting reduced NAD+/NAHD ratio altered expression NAD+-dependent deacetylases SIRT1 SIRT3. These observations suggest some aspects FASDs may be linked aging due programmed regulation bioenergetics.

Язык: Английский

Процитировано

1
Chronic paternal alcohol exposures induce dose-dependent changes in offspring craniofacial shape and symmetry DOI Creative Commons
Samantha Higgins, Sanat S. Bhadsavle,

Matthew N. Gaytan

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Июль 1, 2024

Although dose-response analyses are a fundamental tool in developmental toxicology, few studies have examined the impacts of toxicant dose on non-genetic paternal inheritance offspring disease and dysgenesis. In this study, we used geometric morphometric to examine different levels preconception alcohol exposure craniofacial shape symmetry mouse model. Procrustes ANOVA followed by canonical variant analysis facial relationships revealed that Low-, Medium-, High-dose treatments each induced distinct changes symmetry. Our identified threshold between 1.543 2.321 g/kg/day. Below threshold, shape, including right shift features. contrast, above exposures caused shifts both center, disrupting Consistent with previous clinical studies, predominantly mapped regions lower portion face, mandible (lower jaw) maxilla (upper jaw). Notably, high-dose also impacted positioning eye. reveal use may be an unrecognized factor contributing incidence severity alcohol-related defects, complicating diagnostics fetal spectrum disorders.

Язык: Английский

Процитировано

0