Toxicology Reports,
Год журнала:
2018,
Номер
5, С. 1140 - 1152
Опубликована: Янв. 1, 2018
Caffeine
is
a
widely
recognized
psychostimulant
compound
with
long
history
of
consumption
by
humans.
While
it
has
received
significant
amount
attention
there
still
much
to
be
learned
respect
its
toxicology
in
humans,
especially
cases
overdose.
A
review
the
and
clinical
caffeine
including
features,
pharmacokinetics,
toxicokinetics,
thorough
examination
mechanism
action
management/treatment
strategies
are
undertaken.
higher
(i.e.,
several
grams)
quantities
known
cause
toxicity
potentially
lethality,
mainly
younger
individuals
who
have
experienced
severe
side
effects
death
despite
consuming
doses
not
otherwise
such
harm
troubling
deserves
further
study.
An
attempted
case
reconstruction
performed
an
effort
shed
light
on
this
issue
focus
pharmacokinetics
pharmacodynamics
caffeine.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Фев. 9, 2022
Evidence
suggests
that
caffeine
(CF)
reduces
cardiovascular
disease
(CVD)
risk.
However,
the
mechanism
by
which
this
occurs
has
not
yet
been
uncovered.
Here,
we
investigated
effect
of
CF
on
expression
two
bona
fide
regulators
circulating
low-density
lipoprotein
cholesterol
(LDLc)
levels;
proprotein
convertase
subtilisin/kexin
type
9
(PCSK9)
and
receptor
(LDLR).
Following
observation
reduced
PCSK9
levels
increased
hepatic
LDLR
expression,
additional
CF-derived
analogs
with
potency
for
inhibition
compared
to
itself
were
developed.
The
PCSK9-lowering
was
subsequently
confirmed
in
a
cohort
healthy
volunteers.
Mechanistically,
demonstrate
increases
endoplasmic
reticulum
(ER)
Ca2+
block
transcriptional
activation
sterol
regulatory
element-binding
protein
2
(SREBP2)
responsible
regulation
PCSK9,
thereby
increasing
clearance
LDLc.
Our
findings
highlight
ER
as
master
regulator
metabolism
identify
may
protect
against
CVD.
Nutrients,
Год журнала:
2018,
Номер
10(5), С. 530 - 530
Опубликована: Апрель 25, 2018
Improving
cerebrovascular
function
may
be
a
key
mechanism
whereby
healthy
lifestyle,
of
which
diet
combined
with
increased
physical
activity
levels
is
cornerstone,
protects
against
cognitive
impairments.
In
this
respect,
effects
on
cerebral
blood
flow
(CBF)—a
sensitive
physiological
marker
function—are
major
interest.
This
review
summarizes
the
impact
specific
dietary
determinants
and
exercise
CBF
in
adults
discusses
relation
between
these
potential
changes
function.
A
limited
number
randomized
controlled
trials
have
already
demonstrated
beneficial
an
acute
intake
nitrate
polyphenols
CBF,
but
evidence
for
relationship
as
well
improvements
functioning
limited.
Moreover,
long-term
trans-resveratrol
supplementation
has
been
shown
to
increase
populations
at
risk
accelerated
decline.
Long-term
n-3
long-chain
polyunsaturated
fatty
acids
also
related
performance
not
yet
found.
Significant
decreases
perfusion
were
observed
by
commonly
consumed
amounts
caffeine,
while
alcohol
was
dose-dependent
way.
However,
are
clear.
Finally,
training
promising
approach
improve
increases
contribute
following
levels.
Nutrients,
Год журнала:
2020,
Номер
12(10), С. 3080 - 3080
Опубликована: Окт. 9, 2020
Caffeine
occurs
naturally
in
various
foods,
such
as
coffee,
tea,
and
cocoa,
it
has
been
used
safely
a
mild
stimulant
for
long
time.
However,
excessive
caffeine
consumption
(1~1.5
g/day)
can
cause
poisoning
(caffeinism),
which
includes
symptoms
anxiety,
agitation,
insomnia,
gastrointestinal
disorders.
Recently,
there
increasing
interest
the
effect
of
protective
factor
or
risk
neurological
psychiatric
Currently,
importance
personalized
medicine
is
being
emphasized,
research
on
sex/gender
differences
needs
to
be
conducted.
Our
review
focuses
several
disorders
with
respect
sex
provide
better
understanding
use
those
The
findings
may
help
establish
new
strategies
developing
sex-specific
therapies.
Brain Sciences,
Год журнала:
2019,
Номер
9(8), С. 178 - 178
Опубликована: Июль 26, 2019
This
paper
presents
the
first
comprehensive
review
on
vigilance
enhancement
using
both
conventional
and
unconventional
means,
further
discusses
resulting
contradictory
findings.
It
highlights
key
differences
observed
between
research
findings
argues
that
variations
of
experimental
protocol
could
be
a
significant
contributing
factor
towards
such
results.
Furthermore,
reveals
effectiveness
means
in
reduction
decrement
compared
to
means.
Meanwhile,
discussion
challenges
techniques
is
presented,
with
several
suggested
recommendations
alternative
strategies
maintain
an
adequate
level
for
task
at
hand.
Additionally,
this
provides
evidence
support
use
studies,
regardless
their
practical
challenges.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2021,
Номер
63(9), С. 1238 - 1261
Опубликована: Авг. 28, 2021
Coffee
is
one
of
the
most
popular
beverages
worldwide;
however,
its
impact
on
health
outcomes
and
adverse
effects
not
fully
understood.
The
current
review
aims
to
establish
an
update
about
benefits
coffee
consumption
highlighting
side
effects,
finally
coming
up
with
attempt
provide
some
recommendations
doses.
A
literature
using
PubMed/Medline
database
was
carried
out
data
were
summarized
by
applying
a
narrative
approach
available
evidence
based
literature.
main
findings
following:
first,
may
contribute
prevention
inflammatory
oxidative
stress-related
diseases,
such
as
obesity,
metabolic
syndrome
type
2
diabetes;
second,
seems
be
associated
lower
incidence
several
types
cancer
reduction
in
risk
all-cause
mortality;
finally,
400
mg/day
(1-4
cups
per
day)
caffeine
safe.
However,
time
gap
between
drugs
should
taken
into
account
order
avoid
interaction.
cross-sectional
or/and
observational
studies
association
intake
outcomes;
thus,
randomized
controlled
are
needed
identify
causality
link.
Nutrients,
Год журнала:
2022,
Номер
14(16), С. 3367 - 3367
Опубликована: Авг. 17, 2022
Nootropics,
also
known
as
"smart
drugs"
are
a
diverse
group
of
medicinal
substances
whose
action
improves
human
thinking,
learning,
and
memory,
especially
in
cases
where
these
functions
impaired.
This
review
provides
an
up-to-date
overview
the
potential
effectiveness
importance
nootropics.
Based
on
their
nature
effects,
this
heterogeneous
drugs
has
been
divided
into
four
subgroups:
classical
nootropic
compounds,
increasing
brain
metabolism,
cholinergic,
plants
extracts
with
effects.
Each
subgroup
nootropics
contains
several
main
representatives,
for
each
one,
its
uses,
indications,
experimental
treatments,
dosage,
possible
side
effects
contraindications
discussed.
For
plant
extracts,
there
is
brief
description
representative,
occurrence,
history,
chemical
composition
part.
Lastly,
specific
recommendations
regarding
use
by
both
ill
healthy
individuals
summarized.
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2023,
Номер
22(3), С. 1686 - 1721
Опубликована: Март 1, 2023
Abstract
The
functional
components
in
tea
confer
various
potential
health
benefits
to
humans.
To
date,
several
special
products
featuring
(STPFCs)
have
been
successfully
developed,
such
as
O
‐methylated
catechin‐rich
tea,
γ‐aminobutyric
acid‐rich
low‐caffeine
and
selenium‐rich
products.
STPFCs
some
unique
enhanced
when
compared
with
conventional
products,
which
can
meet
the
specific
needs
preferences
of
different
groups
huge
market
potential.
processing
strategies
improve
by
regulating
component
content
an
active
area
research
food
science.
fresh
leaves
varieties
rich
are
used
raw
materials,
technologies
employed
prepare
STPFCs.
Huge
progress
has
achieved
development
these
However,
current
status
not
yet
systematically
reviewed.
Here,
studies
on
comprehensively
reviewed
a
focus
their
strategies.
Additionally,
other
chemical
be
developed
into
teas
application
industry
discussed.
Finally,
suggestions
promises
challenges
for
future
study
provided.
This
paper
might
shed
light
Future
should
screening
varieties,
identifying
new
components,
evaluating
health‐promoting
effects,
improving
flavor
quality,
elucidating
interactions
between
components.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2023,
Номер
64(28), С. 10164 - 10186
Опубликована: Июнь 20, 2023
The
knowledge
of
the
relationship
between
chemical
structure
food
components
with
their
mechanisms
action
is
crucial
for
understanding
diet
health
benefits.
This
review
relates
variability
present
in
coffee
beverages
involved
key
physiological
events,
supporting
as
a
polyvalent
functional
food.
Coffee
intake
has
been
related
several
health-promoting
properties
such
neuroprotective
(caffeine,
chlorogenic
acids
and
melanoidins),
anti-inflammatory
acids,
melanoidins,
diterpenes),
microbiota
modulation
(polysaccharides,
acids),
immunostimulatory
(polysaccharides),
antidiabetic
(trigonelline,
antihypertensive
(chlorogenic
acids)
hypocholesterolemic
lipids).
Nevertheless,
caffeine
diterpenes
are
ambivalent
effects
on
health.
Additionally,
large
range
potentially
harmful
compounds,
including
acrylamide,
hydroxymethylfurfural,
furan,
advanced
glycation
end
products,
formed
during
roasting
beverages.
However,
part
daily
human
dietary
healthy
habits,
configuring
paradox.
