Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 19, 2025
Type
2
diabetes
(T2D)
is
a
widespread
metabolic
disorder
marked
by
hyperglycemia,
arising
from
insulin
resistance
and
relative
deficiency.
This
review
investigates
the
critical
role
of
Na+/K+-ATPase
(NKA),
transmembrane
protein
essential
for
maintaining
cellular
ion
gradients,
in
pathophysiology
T2D.
We
provide
an
overview
NKA's
biological
functions,
emphasizing
its
involvement
signaling
pathways,
secretion,
glucose
homeostasis.
The
potential
NKA
as
therapeutic
target
T2D
analyzed,
showcasing
innovative
strategies
such
activators,
gene
therapy,
stem
cell
therapy
aimed
at
enhancing
activity
to
achieve
better
glycemic
control.
Additionally,
multifunctional
viability
modulating
immune
responses
islet
transplantation
may
offer
benefits
improving
transplant
outcomes.
By
elucidating
complex
interactions
between
T2D,
this
aims
shed
light
on
developing
novel
interventions
that
meet
multifaceted
needs
individuals
suffering
chronic
condition,
ultimately
their
health
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 438 - 438
Опубликована: Фев. 11, 2025
Background/Objectives:
Type
2
diabetes
mellitus
(T2DM)
and
its
macro-
microvascular
complications
are
major
health
concerns
with
multiple
factors,
like
advanced
end
glycation
products
(AGEs),
in
the
background.
AGEs
induce
long-lasting
functional
modification
of
proteins
collagen
vascular
wall
nerve
tissue.
We
investigated
effect
alpha-lipoic
acid
(ALA)
treatment
on
AGEs,
soluble
AGE
receptor
(sRAGE),
AGE/sRAGE
ratio,
parameters
endothelial
dysfunction
their
correlations.
Methods:
In
our
6-month
intervention
study,
54
T2DM
patients
neuropathy
treated
according
to
actual
therapeutic
guidelines
unchanged
oral
antidiabetic
drugs
were
included
by
daily
administration
600
mg
ALA.
A
total
24
gender
age-matched
without
served
as
controls.
Results:
work,
we
first
demonstrated
attenuating
alpha
lipoic
therapy
humans
(11.89
(9.44–12.88)
10.95
(9.81–12.82)
AU/μg
(p
=
0.017)).
sRAGE
levels
or
AGEs/sRAGE
ratio
not
affected
ALA
presence
neuropathy.
found
a
correlation
between
changes
improvement
current
perception
threshold
progranulin
levels,
an
inverse
change
asymmetric
dimethylarginine.
Conclusions:
According
results,
decreases
which
may
contribute
clinically
well-known
beneficial
diabetic
function.
Antibiotics,
Год журнала:
2025,
Номер
14(2), С. 198 - 198
Опубликована: Фев. 14, 2025
Background:
Diabetes
mellitus
exacerbates
immune
dysfunction,
leading
to
higher
susceptibility
infections.
This
study
investigated
the
effects
of
antibiotics
on
macrophage
functions
under
high
glucose
conditions
mimic
a
diabetic
context.
Methods:
Using
murine
cell
line
RAW
264.7,
present
evaluated
cytotoxicity,
phagocytosis,
bactericidal
activity,
and
pro-inflammatory
cytokine
production
after
treatment
with
four
antibiotics:
oxytetracycline,
ciprofloxacin,
sulfamethoxazole-trimethoprim,
cefotaxime.
Results:
All
demonstrated
no
cytotoxicity
across
1×-8×
MIC
concentrations.
Hyperglycemia
significantly
impaired
phagocytosis
activity
while
inducing
mediator
markers,
IL-1,
IL-6,
TNF-α,
iNOS.
Only
ciprofloxacin
improved
phagocytic
achieving
levels
comparable
low
control.
Treatments
cefotaxime
enhanced
without
altering
profile.
Conclusions:
These
findings
underscore
negative
effect
suggest
that
may
be
potential
therapeutic
option
for
diabetes-associated
Journal of Pharmacy and Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
This
research
studied
two
extracts
from
Treculia
africana
leaves
for
their
potential
against
hyperglycaemia-related
disorders.
The
influence
of
the
on
α-glucosidase
activity
and
albumin
glycation
was
investigated,
cell
viability
estimated
in
HT-29
human
colorectal
cells.
Phenolic
flavonoid
contents
antiradical
were
also
detected.
examined
using
HPLC-DAD
analysis.
methanol
dichloromethane
leaf
showed
a
significant
concentration-dependent
inhibition
(IC50=
3.73
21.28
µg/ml,
respectively).
Both
inhibited
ribose-induced
bovine
serum
250
µg/ml.
Phytochemical
analysis
revealed
presence
chlorogenic
acid
α-mangostin
extracts.
did
not
change
up
to
thus
showing
very
low
cytotoxicity.
extract
T.
manner,
supporting
use
traditional
medicine
control
hyperglycaemia.
Chlorogenic
α-mangostin,
latter
identified
first
time
this
species,
found
leaves.
Further,
vivo
studies
pilot
clinical
trials
should
be
conducted
standardized
evaluate
effectiveness
diabetes
mellitus.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 19, 2025
Type
2
diabetes
(T2D)
is
a
widespread
metabolic
disorder
marked
by
hyperglycemia,
arising
from
insulin
resistance
and
relative
deficiency.
This
review
investigates
the
critical
role
of
Na+/K+-ATPase
(NKA),
transmembrane
protein
essential
for
maintaining
cellular
ion
gradients,
in
pathophysiology
T2D.
We
provide
an
overview
NKA's
biological
functions,
emphasizing
its
involvement
signaling
pathways,
secretion,
glucose
homeostasis.
The
potential
NKA
as
therapeutic
target
T2D
analyzed,
showcasing
innovative
strategies
such
activators,
gene
therapy,
stem
cell
therapy
aimed
at
enhancing
activity
to
achieve
better
glycemic
control.
Additionally,
multifunctional
viability
modulating
immune
responses
islet
transplantation
may
offer
benefits
improving
transplant
outcomes.
By
elucidating
complex
interactions
between
T2D,
this
aims
shed
light
on
developing
novel
interventions
that
meet
multifaceted
needs
individuals
suffering
chronic
condition,
ultimately
their
health
