Stroke in the21stCentury: A Snapshot of the Burden, Epidemiology, and Quality of Life DOI Creative Commons
Eric S. Donkor

Stroke Research and Treatment, Год журнала: 2018, Номер 2018, С. 1 - 10

Опубликована: Ноя. 27, 2018

Stroke is ranked as the second leading cause of death worldwide with an annual mortality rate about 5.5 million. Not only does burden stroke lie in high but morbidity also results up to 50% survivors being chronically disabled. Thus a disease immense public health importance serious economic and social consequences. The set rise over future decades because demographic transitions populations, particularly developing countries. This paper provides overview the21stcentury from perspective.

Язык: Английский

Nitric Oxide and Peroxynitrite in Health and Disease DOI
Pál Pacher, Joseph S. Beckman, Lucas Liaudet

и другие.

Physiological Reviews, Год журнала: 2007, Номер 87(1), С. 315 - 424

Опубликована: Янв. 1, 2007

The discovery that mammalian cells have the ability to synthesize free radical nitric oxide (NO) has stimulated an extraordinary impetus for scientific research in all fields of biology and medicine. Since its early description as endothelial-derived relaxing factor, NO emerged a fundamental signaling device regulating virtually every critical cellular function, well potent mediator damage wide range conditions. Recent evidence indicates most cytotoxicity attributed is rather due peroxynitrite, produced from diffusion-controlled reaction between another radical, superoxide anion. Peroxynitrite interacts with lipids, DNA, proteins via direct oxidative reactions or indirect, radical-mediated mechanisms. These trigger responses ranging subtle modulations cell overwhelming injury, committing necrosis apoptosis. In vivo, peroxynitrite generation represents crucial pathogenic mechanism conditions such stroke, myocardial infarction, chronic heart failure, diabetes, circulatory shock, inflammatory diseases, cancer, neurodegenerative disorders. Hence, novel pharmacological strategies aimed at removing might represent powerful therapeutic tools future. Evidence supporting these roles presented detail this review.

Язык: Английский

Процитировано

5959
Glutamate uptake DOI
Niels C. Danbolt

Progress in Neurobiology, Год журнала: 2001, Номер 65(1), С. 1 - 105

Опубликована: Сен. 1, 2001

Язык: Английский

Процитировано

3908
Glutamate receptor ion channels DOI
Mark L. Mayer

Current Opinion in Neurobiology, Год журнала: 2005, Номер 15(3), С. 282 - 288

Опубликована: Май 25, 2005

Язык: Английский

Процитировано

3667
Glutamate Receptor Ion Channels: Structure, Regulation, and Function DOI
Stephen F. Traynelis, Lonnie P. Wollmuth, Chris J. McBain

и другие.

Pharmacological Reviews, Год журнала: 2010, Номер 62(3), С. 405 - 496

Опубликована: Авг. 17, 2010

The mammalian ionotropic glutamate receptor family encodes 18 gene products that coassemble to form ligand-gated ion channels containing an agonist recognition site, a transmembrane permeation pathway, and gating elements couple agonist-induced conformational changes the opening or closing of pore. Glutamate receptors mediate fast excitatory synaptic transmission in central nervous system are localized on neuronal non-neuronal cells. These regulate broad spectrum processes brain, spinal cord, retina, peripheral system. postulated play important roles numerous neurological diseases have attracted intense scrutiny. description structure, including its elements, reveals complex assembly multiple semiautonomous extracellular domains linked pore-forming element with striking resemblance inverted potassium channel. In this review we discuss International Union Basic Clinical Pharmacology nomenclature, assembly, accessory subunits, interacting proteins, expression translation, post-translational modifications, antagonist pharmacology, allosteric modulation, mechanisms permeation, normal physiological function, as well potential therapeutic use pharmacological agents acting at receptors.

Язык: Английский

Процитировано

3268
Stroke DOI
Geoffrey A. Donnan, Marc Fisher, Malcolm Macleod

и другие.

The Lancet, Год журнала: 2008, Номер 371(9624), С. 1612 - 1623

Опубликована: Май 1, 2008

Язык: Английский

Процитировано

2118
Cell Biology of Ischemia/Reperfusion Injury DOI
Theodore J. Kalogeris, Christopher Baines, Maike Krenz

и другие.

International review of cell and molecular biology, Год журнала: 2012, Номер unknown, С. 229 - 317

Опубликована: Янв. 1, 2012

Язык: Английский

Процитировано

1904
The Science of Stroke: Mechanisms in Search of Treatments DOI Creative Commons
Michael A. Moskowitz, Eng H. Lo, Costantino Iadecola

и другие.

Neuron, Год журнала: 2010, Номер 67(2), С. 181 - 198

Опубликована: Июль 1, 2010

Язык: Английский

Процитировано

1774
Plasticity during stroke recovery: from synapse to behaviour DOI
Timothy H. Murphy, Dale Corbett

Nature reviews. Neuroscience, Год журнала: 2009, Номер 10(12), С. 861 - 872

Опубликована: Ноя. 4, 2009

Язык: Английский

Процитировано

1759
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways DOI
Giles E. Hardingham,

Yuko Fukunaga,

Hilmar Bading

и другие.

Nature Neuroscience, Год журнала: 2002, Номер 5(5), С. 405 - 414

Опубликована: Апрель 15, 2002

Язык: Английский

Процитировано

1625
Apoptosis in neurodegenerative disorders DOI
Mark P. Mattson

Nature Reviews Molecular Cell Biology, Год журнала: 2000, Номер 1(2), С. 120 - 130

Опубликована: Ноя. 1, 2000

Язык: Английский

Процитировано

1557