Cited by Facing stress and inflammation: From the cell to the planet

Impact of COVID-19 vaccination programmes in Europe: lives saved and lessons learned DOI

Oliver J. Watson, Alexandra B. Hogan

The Lancet Respiratory Medicine, Год журнала: 2024, Номер 12(9), С. 663 - 664

Опубликована: Авг. 7, 2024

Язык: Английский

Процитировано

Editorial: Immune studies of SARS-CoV2 and vaccines using preclinical modeling DOI

Cordelia Dunai,

Smita S. Iyer,

William J. Murphy

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 16, 2025

Preclinical animal models remain essential for understanding viral pathogenesis as well the development and assessment of vaccines therapeutic strategies. It is extremely important, particularly immunological studies, to understand species differences limitations both from immune standpoints (summarized in Table 1). Much has been learned about coronaviruses (including pivotal earlier studies on SARS-Co-V) preclinical which shed insights responses underlying them (reviewed by Collins et al).It difficult estimate how many lives saved globally during pandemic, but approximately 1.5 million were WHO European Region first developed tested (1). SARS-CoV-2 virus pathology complex systemic leading challenges best model it preclinically different species. A lot research focussed neutralizing antibodies response against their apparent rapid diminution. Previous demonstrated aberrant inflammatory responses, elderly obese due cytokine release syndrome Chegni al. (2)). Additionally, was shown that inflammation can occur brain even mild COVID-19 infection non-human primate offering an initial insight into other organs, not just lungs, are affected (3).Efforts continue make more similar human scenarios modifying genes method incorporating factors such age, obesity, multiple infections. This special issue covers this concept increased translatability strategies improve vaccines.One mouse difference ACE2, a receptor uses enter cells. Initial using K18-hACE2 transgenic enabled with SARS-CoV-2, however its broader expression representative clinical scenario leads severe wider-spread (4)(5)(6)(7)(8). Fine-tuning model, Liu al introduced ACE2 TMPRSS2 replace orthologous gene loci under control respective murine promoters (9). investigation (with peak load at dpi 4) longer-term useful long-term effects memory.A novel low inoculum also study lacked active replication present neuroinvasive (10). majority cases because very rare find protein parenchyma (11). Despite lack brains SARS-CoV-2-infected K18-hACE2-tg mice, there elevated proinflammatory cytokines increase microglia reactivity indicating indirect activation (10).Intriguingly, quite early interesting phenomenon emerged-the BCG vaccine associated protection (12). However, replicated randomized controlled trials (13,14). Due prevalence health impact tuberculosis, co-infection important issue. Williams investigated mice M. tuberculosis SARS-CoV-2. Counter-intuitively, actually had reduced mortality rate (15). The authors found high levels including TNF IFN-γ vivo vitro PBMCs epithelial cells suggesting activated innate pathways lead broad protective antiviral (15).It efficiency optimize delivery, timing, targets, adjuvants especially since periodic immunizations now recommended persistent generation new variants. While emphasis literature antibodies, generating strong T cell immunity although precise roles poorly understood understudied (16,17). Therefore, B epitopes promising strategy Prakash (18). Other include: intranasal delivery i.e. needle-free all advantages stimulating mucosal Zhou (19); coupling stimulation (CCL20/MIP-3α) Gordy (20); stabilizing spike trimer robust Avila-Nieto (21). Song went step beyond most usually do look than one administration or regimen heterologous boost resulted antibody production (22). These types given paucity assessing repeated vaccinations components means further them.It note have advantage controlling numerous variables (outbred diverse populations, sex, prior pathogen exposure, etc) (summary pros cons Added these regarding tissue assays available, studies. modelling offers ability allow thorough mechanistic dissection reviewed (23). emergence chronic symptoms after infection, post-acute sequelae (PASC), highlight importance determine mechanisms involved. marked changes arise normal aging necessitate area populations risk poor outcome following (24). Given tremendous heterogeneity population along need continuous consideration needs be undertaken result greatest efficacy minimal adverse over time.

Язык: Английский

Процитировано

High-frequency PCR-testing as a powerful approach for SARS-CoV-2 surveillance in the field of critical infrastructure: A longitudinal, retrospective study in a German tertiary care hospital DOI

Bastian Fischer, Martin Farr, Jan Gummert

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0317009 - e0317009

Опубликована: Фев. 6, 2025

A high number of SARS-CoV-2 infections are mild, often even asymptomatic. Because specificity and sensitivity, RT-PCR is considered the gold-standard for COVID-19 testing. The technology played a key role in detecting sources infection at an early stage therefore preventing larger outbreaks. This was especially important case critical infrastructure, such as hospitals. Until now, comprehensive studies concerning impact high-frequency PCR-testing German tertiary care hospitals during pandemic lacking. We analyzed about 285.000 oral swab probes 3.421 healthcare-workers RNA positivity between November 2020 February 2023. Our data show that frequent useful tool surveillance. Due to longitudinal character study, we were able observe variant-specific differences. For example, omicron-variant led reinfection-rates well lower Ct-values. Nevertheless, reinfection rates our hospital much compared other healthcare-worker cohorts described literature, which again attributable testing-regime implemented phase pandemic. further reveal longer infection-duration elderly younger individuals.

Язык: Английский

Процитировано

AVERTED MORTALITY BY COVID-19 VACCINATION IN BELGIUM BETWEEN 2021 AND 2023 DOI

Veerle Stouten,

Izaak Van Evercooren,

Catharina Vernemmen

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

ABSTRACT Background Vaccination campaigns were rolled out primarily to limit the impact of COVID-19 on severe health outcomes, including mortality. Aim We aimed estimate number averted deaths by vaccination in Belgian population aged 65 years and older, between January 2021 2023. Methods Nationwide data infections, vaccine administrations all-cause mortality individually linked. estimated Vaccine Effectiveness against (VE) among persons having received a dose last 6 months, using Cox proportional hazards model adjusted for age, sex, time since vaccination, previous infection, underlying conditions, province income. death was defined as person with laboratory-confirmed SARS-CoV-2 infection who died within specified interval. Based obtained VE estimates, coverage national data, we deaths. Results (0-59 days after vaccination) 65-79 year ≥80 year-olds respectively, at 81.9% (78.1%-85.1%) 74.7% (71.2%-77.7%) during Alpha, 90.5% (88.8%-91.9%) 91.4% (90.4%- 92.4%) Delta 84.0% (81.8%-85.9%) 74.5% (72.4%-76.5%) Omicron period. Among 12,806 (11,633- 13,982), representing 54% reduction (51%-56%) expected (without vaccination). During period reduced 68%, Alpha 31%. Discussion Vaccinating underscoring importance vaccines reducing

Язык: Английский

Процитировано

The burden of COVID-19 death for different cancer types: a large population-based study DOI

You Mo,

Duncan Wei,

Xiaozheng Chen

и другие.

Journal of Global Health, Год журнала: 2025, Номер 15

Опубликована: Фев. 13, 2025

Viral mutations and immune dysfunction still lead to recurrent infections of COVID-19 in cancer patients. Our aim this study was explore the differences cumulative risk death from different types characterise clinical demographic factors associated with death. We conducted a population-based using National Cancer Database, which included all types. calculated age-standardised mortality, mortality. Further, we employed multivariate competing analysis calculate 5.3% patients suffered The highest mortality chronic lymphocytic leukaemia, while lung bronchus exhibited lower risk. Notably, years diagnosis independently predict hazard ratios (HR) cancers were as follows: HR = 1.29 (95% confidence interval (CI) 1.20-1.40, P < 0.001), colon rectum 1.22 CI 1.16-1.29, urinary bladder 1.15-1.30, non-Hodgkin lymphoma 1.17 1.11-1.23, kidney 1.15 1.06-1.24, breast 1.11 1.06-1.16, 0.001). Radiotherapy, chemotherapy, surgical resection did not significantly correlate revealed burden across leukaemia prostate cancer, had Years Based on results, support more prompt assessment treatment for various cancer.

Язык: Английский

Процитировано

‘It's a shot, not a vaccine like MMR’: A new type of vaccine-specific scepticism on twitter/X during the COVID-19 pandemic DOI

Elena Semino,

Tara Coltman-Patel,

William Dance

и другие.

Vaccine X, Год журнала: 2025, Номер unknown, С. 100620 - 100620

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

XBB1.5-Adapted COVID-19 Vaccine Acceptance Among Dialysis and Kidney Transplant Patients: A Bi-National Survey Study DOI

Georg F. Beilhack, Rossella Monteforte, Florian Frommlet

и другие.

Vaccines, Год журнала: 2025, Номер 13(3), С. 213 - 213

Опубликована: Фев. 21, 2025

Background: A decrease in governmental vaccination initiatives and diminishing public enthusiasm for vaccines could jeopardize vaccine uptake, potentially endangering those who are most at risk. In this survey study, we evaluated the current acceptance rates of newly developed monovalent XBB1.5-adapted COVID-19 among kidney transplant recipients dialysis patients Austria Israel identified factors influencing acceptance. Methods: The involved a total 656 aged 18 older was carried out from 20 November to 21 December 2023, Medical University Vienna, Rabin Center Petah Tikva, Israel. Logistic regression analysis used explore relationships between variables such as age, gender, country, past infection status severity, renal replacement therapy, education level, willingness receive annual flu vaccine. Results: showed that 54% 63% expressed modified main hesitancy due concerns about potential side effects, with 44% 53% expressing apprehension. influenza vaccine, age Austria, were key predictors greater Conclusions: This study more than 50% our willing adapted Yet, remained significant barrier even these high-risk groups, despite availability an updated targeting Omicron subvariant XBB1.5.

Язык: Английский

Процитировано

Vaccination Decisions and Social Capital in Japan DOI

Toshihiro Okubo, Ilan Noy

SSM - Population Health, Год журнала: 2025, Номер 30, С. 101769 - 101769

Опубликована: Фев. 26, 2025

Язык: Английский

Процитировано

The impact of public healthcare system on COVID-19 mortality rate in selected European and South Caucasian countries DOI

Gaetano Perone

Eurasian economic review, Год журнала: 2025, Номер unknown

Опубликована: Март 2, 2025