Susceptibility for Some Infectious Diseases in Patients With Diabetes: The Key Role of Glycemia DOI Creative Commons
Jesús Chávez‐Reyes, Carlos Enrique Escárcega‐González, Erika Chavira-Suárez

и другие.

Frontiers in Public Health, Год журнала: 2021, Номер 9

Опубликована: Фев. 16, 2021

Uncontrolled diabetes results in several metabolic alterations including hyperglycemia. Indeed, preclinical and clinical studies have suggested that this condition may induce susceptibility the development of more aggressive infectious diseases, especially those caused by some bacteria (including Chlamydophila pneumoniae, Haemophilus influenzae, Streptococcus among others) viruses [such as coronavirus 2 (CoV2), Influenza A virus, Hepatitis B, etc.]. Although precise mechanisms link glycemia to exacerbated infections remain elusive, hyperglycemia is known a wide array changes immune system activity, in: (i) microenvironment cells (e.g., pH, blood viscosity other biochemical parameters); (ii) supply energy bacteria; (iii) inflammatory response; (iv) oxidative stress result bacterial proliferative metabolism. Consistent with evidence, are typical (and/or worse prognosis) patients hypercaloric diets stressful lifestyle (conditions promote hyperglycemic episodes). On basis, present review particularly focused on: role viral analyzing findings; discussing possible which increase for developing infections; further understanding impact on system.

Язык: Английский

The burden and risks of emerging complications of diabetes mellitus DOI Open Access
Dunya Tomic, Jonathan E. Shaw, Dianna J. Magliano

и другие.

Nature Reviews Endocrinology, Год журнала: 2022, Номер 18(9), С. 525 - 539

Опубликована: Июнь 6, 2022

Язык: Английский

Процитировано

664
Coronavirus Disease (Covid-19) Associated Mucormycosis (CAM): Case Report and Systematic Review of Literature DOI Creative Commons
Deepak Garg, Valliappan Muthu, Inderpaul Singh Sehgal

и другие.

Mycopathologia, Год журнала: 2021, Номер 186(2), С. 289 - 298

Опубликована: Фев. 5, 2021

Язык: Английский

Процитировано

562
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity DOI Creative Commons
Marcin F. Osuchowski, Martin Sebastian Winkler, Tomasz Skirecki

и другие.

The Lancet Respiratory Medicine, Год журнала: 2021, Номер 9(6), С. 622 - 642

Опубликована: Май 7, 2021

The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with devastating consequences. While the medical community has gained insight into epidemiology of COVID-19, important questions remain about clinical complexities and underlying mechanisms disease phenotypes. Severe most commonly involves respiratory manifestations, although other systems are also affected, acute is often followed by protracted complications. Such complex manifestations suggest dysregulates host response, triggering wide-ranging immuno-inflammatory, thrombotic, parenchymal derangements. We review intricacies pathophysiology, its various phenotypes, anti-SARS-CoV-2 response at humoral cellular levels. Some similarities exist between failure origins, but evidence for many distinctive mechanistic features indicates constitutes a new entity, emerging data suggesting involvement an endotheliopathy-centred pathophysiology. Further research, combining basic studies, needed advance understanding pathophysiological characterise immuno-inflammatory derangements across range phenotypes enable optimum care patients COVID-19.

Язык: Английский

Процитировано

481
Global pandemics interconnected — obesity, impaired metabolic health and COVID-19 DOI Creative Commons
Norbert Stefan, Andreas L. Birkenfeld, Matthias B. Schulze

и другие.

Nature Reviews Endocrinology, Год журнала: 2021, Номер 17(3), С. 135 - 149

Опубликована: Янв. 21, 2021

Obesity and impaired metabolic health are established risk factors for the non-communicable diseases (NCDs) type 2 diabetes mellitus, cardiovascular disease, neurodegenerative diseases, cancer nonalcoholic fatty liver otherwise known as associated disease (MAFLD). With worldwide spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2), obesity also emerged important determinants 2019 (COVID-19). Furthermore, novel findings indicate that specifically visceral characteristics such hyperglycaemia, hypertension subclinical inflammation with a high COVID-19. In this Review, we highlight how increase complications mortality in We summarize consequences SARS-CoV-2 infection organ function NCDs. addition, discuss data indicating COVID-19 pandemic could have serious epidemic. As both accelerators COVID-19, might adversely influence efficacy vaccines, propose strategies prevention treatment on clinical population level, particularly while is present. This Review highlights (COVID-19) summarizes function. there discussion implications pandemic.

Язык: Английский

Процитировано

418
Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection DOI Creative Commons
Laura Montefusco, Moufida Ben Nasr, Francesca D’Addio

и другие.

Nature Metabolism, Год журнала: 2021, Номер 3(6), С. 774 - 785

Опубликована: Май 25, 2021

Язык: Английский

Процитировано

368
Risk Factors for Coronavirus Disease 2019 (COVID-19)–Associated Hospitalization: COVID-19–Associated Hospitalization Surveillance Network and Behavioral Risk Factor Surveillance System DOI Creative Commons
Jean Y. Ko, Melissa L. Danielson, Machell Town

и другие.

Clinical Infectious Diseases, Год журнала: 2020, Номер 72(11), С. e695 - e703

Опубликована: Сен. 17, 2020

Abstract Background Data on risk factors for coronavirus disease 2019 (COVID-19)–associated hospitalization are needed to guide prevention efforts and clinical care. We sought identify independently associated with COVID-19–associated hospitalizations. Methods Community-dwelling adults (aged ≥18 years) in the United States hospitalized laboratory-confirmed COVID-19 during 1 March–23 June 2020 were identified from COVID-19–Associated Hospitalization Surveillance Network (COVID-NET), a multistate surveillance system. To calculate rates by age, sex, race/ethnicity strata, COVID-NET data served as numerator Behavioral Risk Factor System estimates population denominator characteristics of interest. Underlying medical conditions examined included hypertension, coronary artery disease, history stroke, diabetes, obesity, severe chronic kidney asthma, obstructive pulmonary disease. Generalized Poisson regression models used adjusted rate ratios (aRRs) hospitalization. Results Among 5416 adults, (all reported aRR [95% confidence interval]) higher among those ≥3 underlying (vs without) (5.0 [3.9–6.3]), obesity (4.4 [3.4–5.7]), (4.0 [3.0–5.2]), diabetes (3.2 [2.5–4.1]), (2.9 [2.3–3.5]), hypertension (2.8 [2.3–3.4]), asthma (1.4 [1.1–1.7]), after adjusting race/ethnicity. Adjusting presence an individual condition, observed aged ≥65 or 45–64 years 18–44 years), males females), non-Hispanic black other race/ethnicities whites). Conclusions Our findings elucidate groups that may benefit targeted preventive therapeutic interventions.

Язык: Английский

Процитировано

327
Indirect acute effects of the COVID-19 pandemic on physical and mental health in the UK: a population-based study DOI Creative Commons
Kathryn E. Mansfield, Rohini Mathur, John Tazare

и другие.

The Lancet Digital Health, Год журнала: 2021, Номер 3(4), С. e217 - e230

Опубликована: Фев. 21, 2021

BackgroundThere are concerns that the response to COVID-19 pandemic in UK might have worsened physical and mental health, reduced use of health services. However, scale problem is unquantified, impeding development effective mitigations. We aimed ascertain what has happened general practice contacts for acute outcomes during pandemic.MethodsUsing de-identified electronic records from Clinical Research Practice Datalink (CPRD) Aurum (covering 13% population), between 2017 2020, we calculated weekly primary care selected conditions: anxiety, depression, self-harm (fatal non-fatal), severe illness, eating disorder, obsessive-compulsive alcohol-related events, asthma exacerbation, chronic obstructive pulmonary disease cardiovascular events (cerebrovascular accident, heart failure, myocardial infarction, transient ischaemic attacks, unstable angina, venous thromboembolism), diabetic emergency. Primary included remote face-to-face consultations, diagnoses hospital discharge letters, secondary referrals, conditions were identified through diagnoses, symptoms, prescribing. Our overall study population individuals aged 11 years or older who had at least 1 year registration with practices contributing CPRD specified period, but denominator populations varied depending on condition being analysed. used an interrupted time-series analysis formally quantify changes after introduction population-wide restrictions (defined as March 29, 2020) compared period before their Jan 1, 7, 2020), data excluded adjustment-to-restrictions (March 8–28).FindingsThe 9 863 903 2017, increased 10 226 939 by 2020. almost all dropped considerably restrictions. The largest reductions observed emergencies (odds ratio 0·35 [95% CI 0·25–0·50]), depression (0·53 [0·52–0·53]), (0·56 [0·54–0·58]). In analysis, exception (0·98 [0·89–1·10]), there was evidence a reduction (anxiety 0·67 [0·66–0·67], disorders 0·62 [0·59–0·66], disorder [0·69 [0·64–0·74]], 0·56 [0·54–0·58], illness 0·80 [0·78–0·83], stroke 0·59 [0·56–0·62], attack 0·63 [0·58–0·67], failure [0·60–0·64], infarction 0·72 [0·68–0·77], angina [0·60–0·87], thromboembolism 0·94 [0·90–0·99], exacerbation 0·88 [0·86–0·90]). By July, except not recovered pre-lockdown levels.InterpretationThere substantial following restrictions, limited recovery Further research needed whether these reflect frequency missed opportunities care. Maintaining health-care access should be key priority future public planning, including further studied sufficiently any unmet need will ramifications people well provision.FundingWellcome Trust Senior Fellowship, Health Data UK.

Язык: Английский

Процитировано

309
An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications DOI Open Access

Uday Hossain,

Abhishek Das, Sumit Ghosh

и другие.

Food and Chemical Toxicology, Год журнала: 2020, Номер 145, С. 111738 - 111738

Опубликована: Сен. 9, 2020

Язык: Английский

Процитировано

300
The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients DOI Creative Commons

Apurva Hariharan,

Abdul Rahman Hakeem, Subathra Radhakrishnan

и другие.

Inflammopharmacology, Год журнала: 2020, Номер 29(1), С. 91 - 100

Опубликована: Ноя. 7, 2020

Язык: Английский

Процитировано

269
Proportion of newly diagnosed diabetes in COVID‐19 patients: A systematic review and meta‐analysis DOI Open Access
Thirunavukkarasu Sathish, Nitin Kapoor, Yingting Cao

и другие.

Diabetes Obesity and Metabolism, Год журнала: 2020, Номер 23(3), С. 870 - 874

Опубликована: Ноя. 27, 2020

The peer review history for this article is available at https://publons.com/publon/10.1111/dom.14269. Data sharing not applicable to as no new data were created or analyzed in study Appendix S1. Supplementary file. Please note: publisher responsible the content functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed corresponding author article.

Язык: Английский

Процитировано

243