Childhood
obesity
and
diabetes
are
increasing
in
the
Philippines.
The
present
study
aimed
to
(1)
estimate
children’s
usual
intake
of
minimally
processed
vs.
highly
foods
(2)
identify
that
contribute
variance
inflammation
after
controlling
for
mothers’
education,
sex
child,
BMI-for-age.
Apparently
healthy
children
enrolled
kindergarten
first
grade
two
public
schools
Metro
Manila
were
included
(n
=
166).
Serum
C-reactive
protein
(CRP)
was
determined
using
a
qualitative
CRP
test.
Dietary
assessed
non-consecutive
24
h
recalls
obtained
from
mothers
or
caretakers
children.
Usual
food
calculated
multiple
source
method
(MSM).
Binary
logistic
regression
used
determine
contributed
inflammation.
Food
categories
predicted
Processed
Rice,
Cereal,
Starch
Products
(comprising
glutinous
rice
products
traditional
cereal
snacks,
instant
noodles,
extruded
chips
crispy
snacks)
(p
0.037,
95%
CI
1.001,
1.021),
Commercial
Baked
biscuits,
cookies,
bread,
cakes,
pastries)
0.005,
1.005,
1.027),
Preserved
Fruit
Vegetables
(dried
fruits
sweetened
soy
products)
0.044,
1.000,
1.034)
BMI-for-age,
sex,
education.
Minimally
did
not
predict
consumption
fresh
fruits,
vegetables,
milk
negligible.
Actions
needed
improve
quality
Filipino
diets.
Gut,
Год журнала:
2024,
Номер
73(11), С. 1893 - 1908
Опубликована: Сен. 25, 2024
The
understanding
that
changes
in
microbiome
composition
can
influence
chronic
human
diseases
and
the
efficiency
of
therapies
has
driven
efforts
to
develop
microbiota-centred
such
as
first
next
generation
probiotics,
prebiotics
postbiotics,
microbiota
editing
faecal
transplantation.
Central
research
is
how
disease
impacts
vice
versa,
yet
there
a
problematic
issue
with
term
'dysbiosis',
which
broadly
links
microbial
imbalances
various
illnesses
without
precision
or
definition.
Another
significant
discussions
defining
'healthy
individuals'
ascertain
what
characterises
healthy
microbiome.
This
involves
questioning
who
represents
healthiest
segment
our
population-whether
it
those
free
from
illnesses,
athletes
at
peak
performance,
individuals
living
healthily
through
regular
exercise
good
nutrition
even
elderly
adults
centenarians
have
been
tested
by
time
achieved
remarkable
longevity.This
review
advocates
for
delineating
'what
defines
microbiome?'
considering
broader
range
factors
related
health
environmental
influences
on
microbiota.
A
undoubtedly
linked
gut
health.
Nevertheless,
very
difficult
pinpoint
universally
accepted
definition
'gut
health'
due
complexities
measuring
functionality
besides
composition.
We
must
take
into
account
individual
variabilities,
diet,
lifestyle,
host
factors.
Moreover,
challenge
distinguishing
causation
correlation
between
overall
presented.The
also
highlights
resource-heavy
nature
comprehensive
assessments,
hinders
their
practicality
broad
application.
Finally,
we
call
continued
nuanced
approach
better
understand
intricate
evolving
concept
health,
emphasising
need
more
precise
inclusive
definitions
methodologies
studying
Frontiers in Nutrition,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 24, 2025
Objective
Apple
consumption
has
a
positive
effect
on
human
health.
Some
studies
have
shown
that
an
appropriate
amount
of
apple
intake
can
reduce
the
incidence
hypertension.
However,
few
investigated
whether
eating
different
forms
apples
same
benefits
as
whole
apples.
This
study
is
aimed
to
evaluate
all-cause
mortality
in
patients
with
Methods
The
included
2,368
All
participants
were
followed
up
for
at
least
10
years.
Cox
regression
model
was
constructed
analyze
correlation
between
apple,
juice,
and
sauce
Results
3–6
times/week
associated
48%
reduction
risk
hypertension
(HR
=
0.52,
95%
CI:
0.37–0.72,
p
<
0.001).
juice
1.02,
0.67–1.56,
0.930)
1.28,
0.59–2.74,
0.531)
tended
increase
death
hypertension,
although
this
did
not
obtain
statistically
result.
Conclusion
Moderate
reduced
whereas
may
death.
Metabolic
syndrome
is,
in
humans,
associated
with
alterations
the
composition
and
localization
of
intestinal
microbiota,
including
encroachment
bacteria
within
colon's
inner
mucus
layer.
Possible
promoters
these
events
include
dietary
emulsifiers,
such
as
carboxymethylcellulose
(CMC)
polysorbate-80
(P80),
which,
mice,
result
altered
microbiota
composition,
encroachment,
low-grade
inflammation
metabolic
syndrome.
While
assessments
gut
have
largely
focused
on
fecal/luminal
samples,
we
hypothesize
an
outsized
role
for
changes
driving
its
consequences.
In
support
this
notion,
herein
report
that
both
CMC
P80
led
to
stark
microbiome,
markedly
distinct
from
those
observed
feces.
Moreover,
transfer
CMC-
P80-fed
mice
germfree
resulted
inflammation,
various
features
Thus,
conclude
mucus-associated
are
pivotal
determinants
inflammatory
tone
host
metabolism.
Gut,
Год журнала:
2025,
Номер
unknown, С. gutjnl - 333925
Опубликована: Янв. 27, 2025
Non-absorbed
dietary
emulsifiers,
including
carboxymethylcellulose
(CMC),
directly
disturb
intestinal
microbiota,
thereby
promoting
chronic
inflammation
in
mice.
A
randomised
controlled-feeding
study
(Functional
Research
on
Emulsifiers
Humans,
FRESH)
found
that
CMC
also
detrimentally
impacts
microbiota
some,
but
not
all,
healthy
individuals.
This
aimed
to
establish
an
approach
for
predicting
individual's
sensitivity
emulsifiers
via
their
baseline
microbiota.
We
evaluated
the
ability
of
vitro
model
(MiniBioReactor
Arrray,
MBRA)
reproduce
and
predict
individual
donor's
emulsifiers.
Metagenomes
were
analysed
identify
signatures
emulsifier
sensitivity.
Exposure
human
microbiotas,
maintained
MBRA,
recapitulated
differential
previously
observed
FRESH
subjects.
Furthermore,
select
control
subjects
(ie,
fed
CMC)
had
microbiotas
highly
perturbed
by
exposure
MBRA
model.
CMC-induced
perturbability
was
associated
with
a
metagenomic
signature,
suggesting
possibility
using
one's
metagenome
Transplant
deemed
CMC-sensitive,
those
insensitive,
into
IL-10-/-
germfree
mice
resulted
overt
colitis
following
feeding.
These
results
suggest
is
consequence
of,
can
thus
be
predicted
by,
examining
paving
way
microbiota-based
personalised
nutrition.
