Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Ноя. 29, 2024
Advanced age is a primary risk factor for adverse COVID-19 outcomes, potentially attributed to immunosenescence and dysregulated inflammatory responses. In the post-pandemic era, with containment measures lifted, elderly remain particularly susceptible, highlighting need intensified focus on immune health management.
Язык: Английский
Annals of Internal Medicine, Год журнала: 2025, Номер unknown
Опубликована: Март 31, 2025
During 2024, there were many practice-changing innovations in the field of endocrinology, particularly related to use glucagon-like peptide-1 receptor agonists (GLP-1RAs). From substantial new evidence published 10 studies are highlighted that offer critical information for clinicians who manage or comanage patients with endocrine disorders including prediabetes, diabetes, obesity, and hyperparathyroidism. Two articles focused on GLP-1RAs multiple clinical settings not studied original GLP-1RA trials, after bariatric surgery before endoscopy. additional explore risk thyroid cancer prescribed effect a chronic kidney disease type 2 diabetes. Three investigate opportunities deintensification insulin frequency an alternate method delivery One article explores cardiometabolic effects intermittent fasting persons prediabetes The last incidence diabetes SARS-CoV-2 infection skeletal parathyroidectomy as treatment results each study have direct care
Язык: Английский
Процитировано
1
BMJ Open Diabetes Research & Care, Год журнала: 2025, Номер 13(1), С. e004727 - e004727
Опубликована: Янв. 1, 2025
Introduction The study aimed to assess the effect of COVID-19 on hepatic lipid (HL) content, fibrosis risk, and adiposity in persons with type 2 diabetes. Research design methods Participants diabetes a history mild (n=15, age 58±12 years, body mass index 30.9±5.2 kg/m ) were examined before (baseline) 1 year (12±2 months) after (follow-up) recovery from COVID-19. Investigations for changes metabolic risk comprised clinical examination, fasting blood sampling MR-based measurements. Potential corrected time course respective parameters group participants who did not contract over same (n=14, 61±6 30.0±4.6 ). Results resulted relative increase HL content 56% (95% CI 18%, 106%; p=0.04) measured as proton density fat fraction (HL-PDFF), absence While no stiffness volume, intramyocellular lipids, whole-body, subcutaneous visceral adipose tissue volumes well homeostatic model assessment insulin resistance beta-cell function observed. Conclusions History is associated higher HL-PDFF following infection. Trial registration number NCT01055093 .
Язык: Английский
Процитировано
0
Infectious Diseases & Immunity, Год журнала: 2025, Номер unknown
Опубликована: Март 4, 2025
Abstract Long coronavirus disease (COVID) is defined as the continuation or development of new symptoms three months after severe acute respiratory syndrome 2 (SARS-CoV-2) infection, and that last for at least two months, with no other explanation their cause. This includes various clinical manifestations affect multiple organ systems, such complications in respiratory, cardiovascular, neurological, musculoskeletal systems. The most commonly reported include fatigue, cognitive dysfunction, dyspnea, chest pain; however, prevalence severity these vary greatly among individuals. underlying mechanisms long COVID are complex multifaceted, encompassing viral persistence, immune system mitochondrial abnormalities, endothelial impairment, alterations microbiome. Further, has imposed a significant burden on individuals, healthcare economy by impairing an individual’s quality life functional capacity, thereby increasing costs demand care rehabilitation services. review summarizes definition, phenotypes, mechanisms, current treatment advancements highlights specific research directions future investigation.
Язык: Английский
Процитировано
0
JAMA Network Open, Год журнала: 2025, Номер 8(4), С. e252959 - e252959
Опубликована: Апрель 2, 2025
This cohort study estimates the risk of new-onset type 2 diabetes after Delta or Omicron variant SARS-CoV-2 infection among vaccinated adults in Singapore.
Язык: Английский
Процитировано
0
The Lancet Diabetes & Endocrinology, Год журнала: 2024, Номер 12(8), С. 508 - 510
Опубликована: Июль 23, 2024
Язык: Английский
Процитировано
2
Pathogens, Год журнала: 2024, Номер 13(12), С. 1109 - 1109
Опубликована: Дек. 15, 2024
Antibody-dependent enhancement (ADE) is a phenomenon in which antibodies enhance subsequent viral infections rather than preventing them. Sub-optimal levels of neutralizing individuals infected with dengue virus are known to be associated severe disease upon reinfection different serotype. For Severe Acute Respiratory Syndrome Coronavirus type-2 infection, three types ADE have been proposed: (1) Fc receptor-dependent infection cells expressing receptors, such as macrophages by anti-spike antibodies, (2) receptor-independent epithelial and (3) cytokine production anti-nucleocapsid antibodies. This review focuses on the induced examining its potential role COVID-19 during contribution post-acute sequelae COVID-19, i.e., prolonged symptoms lasting at least months after acute phase disease. We also discuss protective effects recently identified that neutralize Omicron variants.
Язык: Английский
Процитировано
2
Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 27(2), С. 767 - 776
Опубликована: Ноя. 20, 2024
Abstract Background People hospitalised for coronavirus disease 2019 (COVID‐19) have elevated incidence of diabetes. However, it is unclear whether this due to shared risk factors, confounding or stress hyperglycaemia in response acute illness. Methods We analysed a multicentre prospective cohort study (PHOSP‐COVID) people ≥18 years discharged from NHS hospitals across the United Kingdom following COVID‐19. Individuals were included if they attended at least one research visit with HbA1c measurement within 14 months discharge and had no history diabetes baseline. The primary outcome was new onset (any type), as defined by first glycated haemoglobin (HbA1c) ≥6.5% (≥48 mmol/mol). Follow‐up censored last measurement. Age‐standardised rates rate ratios (adjusted age, sex, ethnicity, length hospital stay, body mass index, smoking, physical activity, deprivation, hypertension, hyperlipidaemia/hypercholesterolaemia, intensive therapy unit admission, invasive mechanical ventilation, corticosteroid use C‐reactive protein score) calculated using Poisson regression. Incidence compared control groups published clinical trials applying same inclusion exclusion criteria, where possible. Results 91.4 per 1000 person‐years higher South Asian (incidence [IRR] = 3.60; 1.77, 7.32; p < 0.001) Black ethnic (IRR 2.36; 1.07, 5.21; 0.03) White groups. When restricted similar characteristics, those UK data. Conclusion Diabetes hospitalisation COVID‐19 high, but remains uncertain disproportionately than pre‐pandemic levels.
Язык: Английский
Процитировано
0
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Ноя. 29, 2024
Advanced age is a primary risk factor for adverse COVID-19 outcomes, potentially attributed to immunosenescence and dysregulated inflammatory responses. In the post-pandemic era, with containment measures lifted, elderly remain particularly susceptible, highlighting need intensified focus on immune health management.
Язык: Английский
Процитировано
0