Global burden of metabolic diseases, 1990–2021

Metabolism, Год журнала: 2024, Номер 160, С. 155999 - 155999

Опубликована: Авг. 14, 2024

Язык: Английский

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Neglected tropical diseases risk correlates with poverty and early ecosystem destruction

Infectious Diseases of Poverty, Год журнала: 2023, Номер 12(1)

Опубликована: Апрель 10, 2023

Abstract Background Neglected tropical diseases affect the most vulnerable populations and cause chronic debilitating disorders. Socioeconomic vulnerability is a well-known important determinant of neglected diseases. For example, poverty sanitation could influence parasite transmission. Nevertheless, quantitative impact socioeconomic conditions on disease transmission risk remains poorly explored. Methods This study investigated role variables in predictive capacity models zoonoses using decade epidemiological data (2007–2018) from Brazil. Vector-borne this included dengue, malaria, Chagas disease, leishmaniasis, Brazilian spotted fever, while directly-transmitted zoonotic schistosomiasis, leptospirosis, hantaviruses. Environmental predictors were combined with infectious to build environmental socioenvironmental sets ecological niche their performances compared. Results found be as influencing estimated likelihood across large spatial scales. The combination improved overall model accuracy (or power) by 10% average ( P < 0.01), reaching maximum 18% case dengue fever. Gross domestic product was variable (37% relative importance, all individual exhibited 0.00), showing decreasing relationship indicating major factor for Loss natural vegetation cover between 2008 2018 (42% 0.05) among models, exhibiting probability, that these are especially prevalent areas where ecosystem destruction its initial stages lower when more advanced stages. Conclusions Destruction ecosystems coupled low income explain macro-scale probability Addition improves forecasts tandem variables. Our results highlight efficiently address diseases, public health strategies must target both reduction cessation forests savannas.

Язык: Английский

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Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Апрель 25, 2024

Abstract Dengue is the most prevalent mosquito-borne viral disease in humans, and cases are continuing to rise globally. In particular, islands Caribbean have experienced more frequent outbreaks, all four dengue virus (DENV) serotypes been reported region, leading hyperendemicity increased rates of severe disease. However, there significant variability regarding surveillance reporting between islands, making it difficult obtain an accurate understanding epidemiological patterns Caribbean. To investigate this, we used travel genomic epidemiology reconstruct outbreak dynamics, DENV serotype turnover, spread within region from 2009-2022. We uncovered two recent DENV-3 introductions Asia, one which resulted a large Cuba, was previously under-reported. also show that while outbreaks can be synchronized they often caused by different serotypes. Our study highlights importance infected travelers provide snapshot local transmission areas with limited suggests may pose major public health threat region.

Язык: Английский

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Realising a global One Health disease surveillance approach: insights from wastewater and beyond

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 22, 2024

Abstract One Health is a recognition of the shared environment inhabited by humans, animals and plants, impact their interactions on health all organisms. The COVID-19 pandemic highlighted need for framework pathogen surveillance in tractable paradigm to allow timely detection response threats human animal health. We present case studies centered around recent global approach tackle antimicrobial resistance current interest wastewater testing, with concept “one sample many analyses” be further explored as most appropriate means initiating this endeavor.

Язык: Английский

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Pathogens and planetary change

Опубликована: Янв. 15, 2025

Emerging infectious diseases, biodiversity loss, and anthropogenic environmental change are interconnected crises with massive social ecological costs. In this Review, we discuss how pathogens parasites responding to global change, the implications for pandemic prevention conservation. Ecological evolutionary principles help explain why both pandemics wildlife die-offs becoming more common; land-use loss often followed by an increase in zoonotic vector-borne diseases; some species, such as bats, host so many emerging pathogens. To prevent next pandemic, scientists should focus on monitoring limiting spread of a handful high-risk viruses, especially at key interfaces farms live-animal markets. But address much broader set disease risks associated Anthropocene, decision-makers will need develop comprehensive strategies that include pathogen surveillance across species ecosystems; conservation-based interventions reduce human–animal contact protect health; health system strengthening; improvements epidemic preparedness response. Scientists can contribute these efforts filling gaps data, expanding evidence base disease–driver relationships interventions. This Review explores relationship between diseases connected changes Anthropocene.

Язык: Английский

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Progress and challenges in infectious disease surveillance and early warning

Medicine Plus, Год журнала: 2025, Номер unknown, С. 100071 - 100071

Опубликована: Янв. 1, 2025

Язык: Английский

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Global prioritization of endemic zoonotic diseases for conducting surveillance in domestic animals to protect public health

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2023, Номер 378(1887)

Опубликована: Авг. 20, 2023

Zoonotic diseases (zoonoses) originating from domestic animals pose a significant risk to people's health and livelihoods, in addition jeopardizing animal production. Effective surveillance of endemic zoonoses at the level is crucial assessing disease burden risk, providing early warning prevent epidemics spillover humans. Here we aimed prioritize characterize for which important human infections global scale. A multi-criteria qualitative approach was used, where disease-specific information obtained across literature leading international organizations. Thirty-two were prioritized, all have multi-regional spread, cause unexceptional hosts as sources or sentinels zoonotic infections. Most involve multiple and/or modes transmission, lack specific clinical signs further complicates surveillance. We discuss challenges resource-limited settings, well potential avenues improvement such multi-disease, multi-sectoral digital approaches. Our study will support capacity-building efforts strengthen control their sources. This article part theme issue 'Challenges opportunities fight against neglected tropical diseases: decade London Declaration on NTDs'.

Язык: Английский

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Resurgence of congenital syphilis: new strategies against an old foe

The Lancet Infectious Diseases, Год журнала: 2023, Номер 24(1), С. e24 - e35

Опубликована: Авг. 18, 2023

Язык: Английский

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Prevalence and Antimicrobial Resistance Profile of Salmonella Isolated from Human, Animal and Environment Samples in South Asia: A 10-Year Meta-analysis

Journal of Epidemiology and Global Health, Год журнала: 2023, Номер 13(4), С. 637 - 652

Опубликована: Окт. 26, 2023

Abstract Salmonella is a foodborne zoonotic bacterium, and the antimicrobial-resistant strains of are worldwide health concern. Herein, we employed meta-analysis to determine pooled prevalence its antimicrobial resistance status in human, animal, environmental isolates South Asia. To this end, followed standard guideline Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) statements searching literature three databases namely PubMed, Google Scholar, CAB abstracts, total 100 eligible datasets were finally included which published from January 2010 June 2021. In Asia, random model effect was 14.47% (95% CI: 10.17–20.19) with high degree heterogeneity ( I 2 , 99.8%) overall 70% 63.0–76.0) 23.6%. The temporal distribution (%) against increased 53 77% within 10 years. Out 18 distinct serotypes, S. enterica highly prevalent (14.22%, 95% 4.02–39.64) by pullorum (13.50%, 5.64–29.93) 86.26 90.06, respectively. Noteworthy, nalidixic acid (74.25%) tetracycline (37.64%) found mostly resistant whereas ceftriaxone (1.07%) cefixime (1.24%) sensitive. This systematic review demonstrated that antibiotic profiles increasing over time Thus, adequate hygienic practices, proper use antimicrobials, implementation stewardship imperative halting spread resistance.

Язык: Английский

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Advancing pathogen genomics in resource-limited settings

Cell Genomics, Год журнала: 2023, Номер 3(12), С. 100443 - 100443

Опубликована: Ноя. 17, 2023

Genomic sequencing has emerged as a powerful tool to enhance early pathogen detection and characterization with implications for public health clinical decision making. Although widely available in developed countries, the application of genomics among low-resource, high-disease burden settings remains at an stage. In these contexts, tailored approaches integrating within infectious disease control programs will be essential optimize cost efficiency impact. We propose framework embedding national surveillance plans across spectrum laboratory capacities. adopt approach examine its high-priority diseases relevant resource-limited settings. For each grouping, we assess value proposition inform decision-making, alongside contribution toward research development novel diagnostics, therapeutics, vaccines.

Язык: Английский

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