Archives of Medical Research, Год журнала: 2024, Номер 56(1), С. 103087 - 103087
Опубликована: Окт. 5, 2024
Язык: Английский
Nature Medicine, Год журнала: 2024, Номер 30(6), С. 1559 - 1563
Опубликована: Апрель 29, 2024
Abstract It is unclear how great a challenge pandemic and vaccine fatigue present to public health. We assessed perspectives on coronavirus disease 2019 (COVID-19) routine immunization as well trust in information sources future preparedness survey of 23,000 adults 23 countries October 2023. The participants reported lower intent get COVID-19 booster 2023 (71.6%), compared with 2022 (87.9%). A total 60.8% expressed being more willing vaccinated for diseases other than result their experience during the pandemic, while 23.1% less willing. Trust 11 selected each averaged 7 10-point scale one’s own doctor or nurse World Health Organization, averaging 6.9 6.5, respectively. Our findings emphasize that hesitancy challenges remain health practitioners, underscoring need targeted, culturally sensitive communication strategies.
Язык: Английский
Процитировано
27
Canadian Journal of Cardiology, Год журнала: 2024, Номер 40(6), С. 1123 - 1134
Опубликована: Фев. 28, 2024
Long COVID has been defined by World Health Organization as "continuation or development of new symptoms 3 months after the initial SARS-CoV-2 infection, with these lasting for at least 2 no other explanation". Cardiovascular disease is implicated a risk factor, concomitant condition and consequence COVID. As well heterogeneity in definition, presentation likely underlying pathophysiology COVID, disparities social determinants health, extensively studied described cardiovascular disease, have observed three ways. First, long-term conditions, such its factors, are associated incidence severity previously socioeconomic factors important exacerbating Second, management COVID-19 may themselves lead to distal Third, there way that diagnosed, managed prevented. Together, age, sex, deprivation ethnicity far-reaching implications this post-viral syndrome across spectrum. There similarities differences compared disease. Some fact, inequalities, i.e. rather than simply variations, they represent injustices costs individuals, communities economies. In review current literature, I consider opportunities prevent, least, attenuate special challenges research, clinical practice, public health policy which evolving.
Язык: Английский
Процитировано
8
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 12, 2025
Global evidence on the association between vaccines and renal adverse events (AEs) is inconclusive. This pharmacovigilance study analyzed a total of 120,715,116 reports from VigiBase collected 1967 2022. We evaluated global reporting acute kidney injury (AKI), glomerulonephritis (GN), tubulointerstitial nephritis (TIN) assessed disproportionate signals AEs using odds ratios (ROR) lower limit 95% confidence interval information component (IC025) in comparison with entire database. The number proportion AKI, GN, TIN gradually increased, substantial increase after 2020. Disproportionate AKI was significant for COVID-19 mRNA (ROR, 2.38; IC025, 1.09). Fourteen were significantly higher GN reporting, highest disproportionality observed 13.41; 2.90) hepatitis B 11.35; 3.18). 2.43; 0.99) human papillomavirus 1.75; 0.19) vaccines. Significant patients exposed to multiple vaccines, including alongside increasing vaccine-associated AEs.
Язык: Английский
Процитировано
1
MedComm, Год журнала: 2024, Номер 5(4)
Опубликована: Март 15, 2024
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 deaths. Patients with disease (COVID-19) may suffer from diarrhea, sleep disorders, depression, even cognitive impairment, which is associated long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients COVID-19 alterations microbiota their metabolites, particularly the gut, be involved regulation of immune responses. Consumption probiotics alleviate discomfort by inflammation oxidative stress. pathophysiological process underlying alleviation COVID-19-related symptoms complications targeting unclear. In current study, we summarize latest research evidence together SARS-CoV-2 vaccine use, focus relationship between use. This work provides probiotic-based interventions improve regulating gut systemic immunity. Probiotics also used as adjuvants to efficacy.
Язык: Английский
Процитировано
6
Human Vaccines & Immunotherapeutics, Год журнала: 2025, Номер 21(1)
Опубликована: Янв. 10, 2025
Focusing on vaccines available to adults and not in the immunization schedule, this study investigates preferences factors influencing selecting vaccination clinic locations. It aims provide strategic insights for boosting rates by analyzing adults' decision-making factors. This contributes developing more efficient, patient-focused strategies that tackle vaccine hesitancy improve access sites. We conducted a cross-sectional through "YueMiao" platform from November 1 December 10, 2023, using convenience purposive sampling engage 2014 participants. collected data via online surveys included questions about sociodemographic characteristics, sources of information, satisfaction, impact site selection decisions. Our findings reveal are influenced gender, age, income, history. Participants showed strong preference locations offer convenience, efficiency, transparent pricing, comfortable environment. Analysis service satisfaction at these clinics indicates vaccinated individuals report higher with appointment systems, wait times, hours than those unvaccinated. Furthermore, sites consistently aligns type, majority opting community health centers. results suggest public should concentrate enhancing quality, information transparency elevate adult rates. Future initiatives aim increase trust vaccines, quality sites, effectively utilize digital technology spreading information.
Язык: Английский
Процитировано
0
British Journal of Health Psychology, Год журнала: 2025, Номер 30(2)
Опубликована: Март 7, 2025
Parental decision-making for children's uptake of a relatively novel vaccine and more common could involve different processes. This study aimed to compare the psychological processes relative importance factors influencing parental seasonal influenza vaccination (SIV) COVID-19 vaccination. We adopted mixed-methods approach. Study 1 was qualitative involving 29 parents explore their SIV In 2, data from 632 were collected longitudinally; then, machine learning used quantify identified in that relevant parents' childhood decisions. Alluvial plots predictability baseline intention follow-up revealed as an anchor assess vaccine's risks. Decision-making habitual rule-based, while vaccination, it involved deliberation influenced by negative situational cues like news anecdotal experiences. 2 further found that, situation-varying including distressed emotional states affective response significant. While SIV, past-year behaviour important factor. Baseline reliably predicted but not The convergence quantitative highlighted distinct strategies these two vaccines. Targeting key decisions can enhance effectiveness future campaigns.
Язык: Английский
Процитировано
0
Microbial Biotechnology, Год журнала: 2025, Номер 18(1)
Опубликована: Янв. 1, 2025
ABSTRACT Low‐cost and safe vaccines are needed to fill the vaccine inequity gap for future pandemics. Pichia pastoris is an ideal expression system recombinant protein production due its cost‐effective easy‐to‐scale‐up process. Here, we developed a next‐generation SARS‐CoV2 Omicron BA.1‐based candidate expressed in P. . The receptor binding domain of BA.1 spike (RBD‐Omicron) was produced at 0.35 g/L supernatant. With 60% recovery after two‐step purification, RBD‐Omicron showed 99% purity. After vitro characterisation purified via chromatography, mass spectrometry, calorimetry surface plasmon resonance‐based methods, it injected into mice immunization studies. Three different doses Alum CpG adjuvanted were investigated 10 μg gave highest antigenicity. two vaccination, IgG titers serum reached more than 6 These antibodies also recognized earlier (Delta Plus: B.1.617.2) later (Eris: EG.5, Pirola: BA.2.86) variants. long‐term immunological response measured by analyzing antibody T‐cell splenocytes 60 weeks. Interestingly, Th1 significantly high even year. subvariants dominantly circulating world, so sub‐lineage‐based can be used RBD‐Omicron‐based this study suitable technology transfer transition clinic.
Язык: Английский
Процитировано
0
Future Microbiology, Год журнала: 2024, Номер 19(4), С. 293 - 295
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
2
JMIR Public Health and Surveillance, Год журнала: 2024, Номер 10, С. e56989 - e56989
Опубликована: Ноя. 1, 2024
Abstract Background The imperative arises to study the impact of socioeconomic factors on acceptance SARS-CoV-2 and influenza vaccines amid changes in immunization policies during COVID-19 pandemic. Objective To enhance targeted public health strategies improve age-specific based identified risk factors, this investigated associations between sociodemographic vaccination behaviors pandemic, with emphasis vaccine cost policies. Methods This analyzed data from Korean Community Health Survey 2019‐2022 507,964 participants investigate pandemic period. Cohorts aged 19‐64 years 65 or older were stratified age (years), indicators. cohorts assess influence relevant under by using weighted odds ratio (ROR). Results Among participants, (COVID-19 vaccine) was higher among individuals possibly indicating status, such as education level (age years: ROR 1.34; 95% CI 1.27‐1.40 ≥65 1.19; 1.01‐1.41) income 1.67; 1.58‐1.76 1.21; 1.06‐1.38) for both compared before In context cohort exhibited hesitancy associated care mobility lower general status (ROR 0.89; 0.81‐0.97). Conclusions should focus reducing social participation. younger participation, while efforts prioritize limited access services.
Язык: Английский
Процитировано
2
JAC-Antimicrobial Resistance, Год журнала: 2024, Номер 7(1)
Опубликована: Дек. 26, 2024
An estimated 1.27 million deaths globally were caused by antibiotic-resistant infections in 2019. Outcome 2 of the UK national action plan to combat antimicrobial resistance is improved public engagement and education with a specific measurable target. To evaluate compare years use TARGET antibiotic checklist England's community pharmacies via Pharmacy Quality Scheme (PQS). The was incentivized PQS for 2021-22 2023-24 patients presenting prescription pharmacy during 4 week period each year. A total 406 333 counselled using checklist, 10 081 participating either year 6209 both years. most common indications chest urinary tract amoxicillin nitrofurantoin, respectively, being frequently prescribed antibiotics examined. 27 898 influenza vaccinations delivered prompted discussions whilst checklist. In addition, 140 473 patient information leaflets provided improve knowledge about their condition treatment support future self-care. investment training resources through has opportunities strengthening stewardship equipping them tools use, symptom resolution as well other from Antibiotics Toolkit.
Язык: Английский
Процитировано
0