Precision pharmacotherapy of atomoxetine in children with ADHD: how to ensure the right dose for the right person? DOI Creative Commons
Hong‐Li Guo, Jian Huang, Jie Wang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Окт. 29, 2024

Non-stimulant atomoxetine is recognized in various current clinical guidelines as an important alternative to stimulants for the pharmacological treatment of attention deficit/hyperactivity disorder (ADHD) children. While its efficacy and tolerability core symptoms are established, there considerable inter-individual variability response exposure, highlighting need personalized dosing. In this review, we evaluated existing studies summarized comprehensive evidence supporting implementation therapeutic drug monitoring (TDM) dosing atomoxetine, organized around a series logically structured questions. Although notable gaps achieving across multiple critical elements, available helpful endorse dose adjustments based on TDM

Язык: Английский

Autism, ADHD, and Their Traits in Adults With Bulimia Nervosa and Binge Eating Disorder: A Scoping Review DOI Creative Commons
Lauren Makin,

Elisa Zesch,

Anneke Meyer

и другие.

European Eating Disorders Review, Год журнала: 2025, Номер unknown

Опубликована: Янв. 26, 2025

ABSTRACT Objective This review maps existing literature on the prevalence of autism and ADHD in adult patients with Bulimia Nervosa (BN) Binge Eating Disorder (BED); patient stakeholder perspectives this comorbidity; clinical differences population; potential treatment adaptations or adjunct therapies. is aim to inform future research priorities improve practice. Method As pre‐registered, following PRISMA guidelines, six databases (Embase, MEDLINE via Ovid, PsycINFO, Web Science, CENTRAL, Scopus) were searched for studies regarding and/or (diagnosed, probable, traits) BN BED. Screening data extraction conducted twice independently each record. Results Twenty‐nine included, 25,416 participants, mostly women (69.3%). Thirteen suggested are more common BED than non‐ED populations. One study explored expert BED, while 15 considered options, mainly medications. Conclusion highlights a need experiences, differences, non‐medical options Autistic/ADHD Findings suggest these conditions commonly co‐occur but remain under‐explored terms patient‐centred interventions outcomes.

Язык: Английский

Процитировано

2
Behavioral neuroscience’s inevitable SABV growing pains DOI
Rebecca M. Shansky

Trends in Neurosciences, Год журнала: 2024, Номер 47(9), С. 669 - 676

Опубликована: Июль 20, 2024

Язык: Английский

Процитировано

6
Sex Differences in the Comorbidity between Attention Deficit-Hyperactivity Disorder and Posttraumatic Stress Disorder: A Systematic Literature Review and Meta-Analysis DOI Creative Commons
Julia Wilson,

Doruntina Fida,

Rie Maurer

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Attention Deficit-Hyperactivity Disorder (ADHD) and Posttraumatic Stress (PTSD) are often comorbid share a common core of symptoms. However, sex gender-related factors significantly influence their prevalence, clinical presentation, diagnosis. Here, we conducted systematic literature review meta-analysis to examine differences in ADHD/PTSD comorbidity during childhood adulthood. A scoping PsycINFO PubMed yielded 13 eligible studies with complete outcome data. We fixed-effects meta-analyses the sex-stratified prevalence using pooled odds ratios (OR) 95% confidence interval (CI). Fixed-effects subgroup analyses were performed age as subgroup. Effect size heterogeneity was assessed I 2 index Cochran's Q test. In whole sample (N= 13,585; F= 7005, M= 6580), diagnosis higher females than males (OR = 1.32, p 0.02). Between-study low-to-moderate not significant (I 41%; 0.06), validating model. Age-stratified revealed compared only adult populations (OR=1.41; 0.01). Additionally, more likely be diagnosed both disorders where ADHD primary 1.60; 0.002), employing structured interviews diagnostic tools 1.46; 0.009). Our study is first show that association between PTSD stronger females, suggesting may increase risk for sex-specific manner.

Язык: Английский

Процитировано

0
Anxiety Symptoms Predict Subsequent Depressive Symptoms in Neurodivergent Youth: A 10-Year Longitudinal Study DOI Creative Commons
Stian Orm, Jeffrey J. Wood, Ingrid Nesdal Fossum

и другие.

Research on Child and Adolescent Psychopathology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Abstract Neurodivergent youth often experience anxiety and depressive symptoms that may hamper adaptive functioning well-being. There is little knowledge of how depression are related in neurodivergent youth. Therefore, we aimed to examine whether the relationship between uni- or bidirectional neurodiverse We assessed self-reported over time 173 ( M baseline age = 11.7 years, SD 2.1, 64% males, 36% females). The sample comprised 38 autistic youth, 85 diagnosed with attention-deficit/hyperactivity disorder (ADHD), 50 comparison at (T1), 2-year follow-up (T2, 97% retention), 10-year (T3, 73% retention). used cross-lagged models analyze data. In more T1 T2 predicted T3. Preceding were linked later symptoms, even after accounting for autoregressive effects symptoms. results consistent a prodromal model which can independently foreshadow emergence course development among Potentially, addressing autism ADHD could play role preventing onset depression.

Язык: Английский

Процитировано

0
A Review of Sex and Gender Factors in Stimulant Treatment for ADHD: Knowledge Gaps and Future Directions DOI Creative Commons
Iris L. Rapoport, Annabeth P. Groenman

Journal of Attention Disorders, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Objective: Stimulant medications are the primary pharmacological intervention for ADHD, yet our understanding of how sex and gender impact stimulant treatment outcomes remains limited. Clinical guidelines do not differ female male individuals despite possible gender-related differences in effectiveness, adverse events, pharmacokinetics. This theoretical framework identifies five key knowledge gaps relating to effects treatment. Method: We investigate trajectories girls women with ADHD from diagnosis prescription daily use outcomes. examine reproductive life transitions hormonal fluctuations their interactions socialization gendered expectations on stigma, adherence. Results: By synthesizing existing literature, proposing testable predictions, suggesting future research directions, we highlight urgent need studies that systematically these factors. Conclusion: Addressing could significantly improve particularly during biological role transitions.

Язык: Английский

Процитировано

0
An item-level systematic review of the presentation of ADHD in females DOI Creative Commons

Tamara Williams,

Louise Horstmann,

Laiba Kayani

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер unknown, С. 106064 - 106064

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Single–dose methylphenidate induces shift in functional connectivity associated with positive longer term clinical response in adult attention–deficit/hyperactivity disorder DOI Creative Commons
Charlotte M. Pretzsch, Valeria Parlatini, Declan Murphy

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 17, 2025

Язык: Английский

Процитировано

0
Perceptions of Stigma and Social Inclusion Amongst a Sample of University Students with ADHD in Ireland DOI Creative Commons
Scott Smith, Joanne McVeigh

Disabilities, Год журнала: 2025, Номер 5(1), С. 24 - 24

Опубликована: Фев. 26, 2025

Attention deficit hyperactivity disorder (ADHD) is a neurological generally experienced as challenging, it impacts multiple aspects of an individual’s life. There significant gap in the literature surrounding ADHD adults, including experiences stigma and social inclusion from perspective people with ADHD. This study aimed to explore perceptions amongst sample university students living Ireland. Nine semi-structured interviews were conducted seven participants (four men three women), two follow-up interviews. The all official diagnosis Data analysed using descriptive interpretive method Constant Comparison Analysis. In total, sixteen categories (themes) extracted classified into five overarching domains: informational access, access healthcare, attitudinal inclusion, academic accommodations. findings indicated that adversely affects students’ experience inclusion. Barriers effective negative attitudes towards ADHD, misinformation/lack information highlighted risk factors for feelings exclusion. Universities should include disabilities when designing policies provide accommodations support them. Additionally, greater awareness imperative improving

Язык: Английский

Процитировано

0
Puberty and ADHD: A scoping review and framework for future research DOI Creative Commons
Emily Friedel, Nandita Vijayakumar, Lexy Staniland

и другие.

Clinical Psychology Review, Год журнала: 2025, Номер 117, С. 102567 - 102567

Опубликована: Март 5, 2025

Язык: Английский

Процитировано

0
Depression and anxiety are increased in autism and ADHD: Evidence from a young adult community‐based sample DOI Creative Commons
J. Simone,

A. de Burca,

Ümit Aydın

и другие.

JCPP Advances, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Abstract Background Autism and attention‐deficit/hyperactivity disorder (ADHD) overlap to a considerable degree have been associated with mental health difficulties, yet there is limited research on this relationship. Young adulthood time of heightened risk for problems in general. The may be greater individuals these conditions, whom societal demands tied transitional heighten the impact internalising behaviours. Elucidating relationships between neurodevelopmental differences vulnerability psychopathology inform future adaptations specialised support. Methods This study explored whether autistic ADHD traits their interaction were symptoms depression anxiety as well meeting diagnostic criteria disorders sample 556 young‐adult twins (mean age 22 years 5 months, 52% female), controlling sex, age, cognitive ability, parental socioeconomic status. Four participant groups created based assessed young adulthood: high traits, low traits. Results High independently higher self‐reported likelihood thresholds an or mood disorder. While co‐occurrence autism exhibited greatest challenges, no evidence was found effects at stringent corrected thresholds. Females levels particularly concomitant psychopathology. Conclusions Our findings suggest that those and/or require individualised care strategies, light complex interplay neurodivergence outcomes. Future explore efficacy psychoeducation specific established therapeutic interventions needed optimise outcomes adults conditions.

Язык: Английский

Процитировано

0