Biomedicines,
Год журнала:
2022,
Номер
10(2), С. 436 - 436
Опубликована: Фев. 13, 2022
Dopamine
is
a
neurotransmitter
that
plays
critical
role
both
peripherally
and
centrally
in
vital
functions
such
as
cognition,
reward,
satiety,
voluntary
motor
movements,
pleasure,
motivation.
Optimal
dopamine
bioavailability
essential
for
normal
brain
functioning
protection
against
the
development
of
neurological
diseases.
Emerging
evidence
shows
gut
microbiota
have
significant
roles
maintaining
adequate
concentrations
via
intricate,
bidirectional
communication
known
microbiota-gut-brain
axis.
The
vagus
nerve,
immune
system,
hypothalamus-pituitary-adrenal
axis,
microbial
metabolites
serve
important
mediators
reciprocal
signaling.
Furthermore,
contain
intrinsic
enzymatic
activity
highly
involved
metabolism,
facilitating
synthesis
well
its
metabolite
breakdown.
This
review
examines
relationship
between
key
genera
Prevotella,
Bacteroides,
Lactobacillus,
Bifidobacterium,
Clostridium,Enterococcus,
Ruminococcus
their
effects
on
dopamine.
dysbiosis
subsequent
impact
dopamine-related
pathological
conditions
Parkinson's
disease
are
also
discussed.
Understanding
modulating
periphery
central
nervous
system
can
help
identify
new
therapeutic
targets
optimize
available
methods
to
prevent,
delay,
or
restore
dopaminergic
deficits
neurologic
metabolic
disorders.
The International Journal of Neuropsychopharmacology,
Год журнала:
2018,
Номер
22(1), С. 37 - 52
Опубликована: Авг. 2, 2018
Microorganisms
can
be
found
almost
anywhere,
including
in
and
on
the
human
body.
The
collection
of
microorganisms
associated
with
a
certain
location
is
called
microbiota,
its
collective
genetic
material
referred
to
as
microbiome.
largest
population
body
resides
gastrointestinal
tract;
thus,
it
not
surprising
that
most
investigated
microbiome
gut
On
average,
hosts
microbes
from
more
than
60
genera
contains
cells
has
been
shown
influence
many
aspects
host
health,
recently
brain.Several
modes
interaction
between
brain
have
discovered,
via
synthesis
metabolites
neurotransmitters,
activation
vagus
nerve,
immune
system.
A
growing
work
implicating
variety
psychological
processes
neuropsychiatric
disorders.
These
include
mood
anxiety
disorders,
neurodevelopmental
disorders
such
autism
spectrum
disorder
schizophrenia,
even
neurodegenerative
Alzheimer's
Parkinson's
diseases.
Moreover,
probable
psychotropic
medications
an
impact
microbiome.Here,
overview
will
provided
for
bidirectional
role
age-associated
cognitive
decline,
neurological
psychiatric
Furthermore,
primer
common
microbiological
bioinformatics
techniques
used
interrogate
provided.
This
review
meant
equip
reader
this
exciting
research
area
permeating
all
areas
biological
psychiatry
research.
Journal of Clinical Medicine,
Год журнала:
2019,
Номер
8(4), С. 444 - 444
Опубликована: Апрель 2, 2019
Atopic
dermatitis
(AD)
is
a
long-standing
inflammatory
skin
disease
that
highly
prevalent
worldwide.
Multiple
factors
contribute
to
AD,
with
genetics
as
well
the
environment
affecting
development.
Although
AD
shows
signs
of
barrier
defect
and
immunological
deviation,
mechanism
underlying
not
understood,
treatment
often
very
difficult.
There
substantial
data
patients
have
disturbed
microbial
composition
lack
diversity
in
their
gut
compared
controls,
which
contributes
onset
atopic
march.
It
clear
whether
change
an
outcome
or
cause
dysfunction
inflammation.
However,
cross-talk
between
commensals
immune
system
now
noticed,
alteration
believed
affect
maturation
innate
adaptive
immunity
during
early
life.
The
novel
concept
modifying
microbiome
by
applying
moisturizers
contain
nonpathogenic
biomass
probiotic
supplementation
years
may
be
preventive
therapeutic
option
high
risk
groups,
but
currently
lacks
evidence.
This
review
discusses
nature
flora
possible
mechanisms
skin–gut
interaction,
implications
correction
AD.
Biomedicines,
Год журнала:
2022,
Номер
10(2), С. 436 - 436
Опубликована: Фев. 13, 2022
Dopamine
is
a
neurotransmitter
that
plays
critical
role
both
peripherally
and
centrally
in
vital
functions
such
as
cognition,
reward,
satiety,
voluntary
motor
movements,
pleasure,
motivation.
Optimal
dopamine
bioavailability
essential
for
normal
brain
functioning
protection
against
the
development
of
neurological
diseases.
Emerging
evidence
shows
gut
microbiota
have
significant
roles
maintaining
adequate
concentrations
via
intricate,
bidirectional
communication
known
microbiota-gut-brain
axis.
The
vagus
nerve,
immune
system,
hypothalamus-pituitary-adrenal
axis,
microbial
metabolites
serve
important
mediators
reciprocal
signaling.
Furthermore,
contain
intrinsic
enzymatic
activity
highly
involved
metabolism,
facilitating
synthesis
well
its
metabolite
breakdown.
This
review
examines
relationship
between
key
genera
Prevotella,
Bacteroides,
Lactobacillus,
Bifidobacterium,
Clostridium,Enterococcus,
Ruminococcus
their
effects
on
dopamine.
dysbiosis
subsequent
impact
dopamine-related
pathological
conditions
Parkinson's
disease
are
also
discussed.
Understanding
modulating
periphery
central
nervous
system
can
help
identify
new
therapeutic
targets
optimize
available
methods
to
prevent,
delay,
or
restore
dopaminergic
deficits
neurologic
metabolic
disorders.
