Prediabetes,
a
state
between
normoglycemia
and
diabetes,
is
increasingly
affecting
population
health;
thus,
it
should
not
be
overlooked.
This
systematic
review
meta-analysis
aimed
to
explore
the
efficacy
of
aerobic
exercise
on
blood
glucose
indicators
among
those
with
prediabetes.
Five
databases,
including
PubMed,
Embase,
Cochrane
Library,
Web
Science,
CINAHL,
were
searched
up
September
2024
identify
randomized
controlled
trials
measuring
effect
levels
individuals
Data
fasting
(FBG),
2-h
postprandial
plasma
(2hPG),
hemoglobin
A1c
(HbA1c)
extracted.
Subgroup
analyses
conducted
based
intervention
duration,
weekly
volume.
In
total,
2518
relevant
records
initially
retrieved,
16
studies
included
in
this
review,
14
providing
sufficient
data
for
meta-analysis.
Compared
control
group,
weighted
mean
difference
(MD)
FBG,
2hPG,
HbA1c
was
−1.33
(95%CI:
−1.87,
−0.89),
−1.00
−1.60,
−0.39),
−1.05
−1.49,
−0.61),
respectively.
analysis
showed
that
pooled
size
greater
subgroup
subjected
≥48
weeks
compared
≤24
intervention,
although
only
FBG
significant
(p
<
0.05).
Weekly
longer
than
180
min/week
led
reductions
shorter
150
min/week,
differences
2hPG
>
Total
1314–1323
MET·min/week
975–1080
Aerobic
effectively
decreases
controls
levels.
The
volume
duration
are
important
factors
reduction
levels,
exhibiting
positive
correlation
within
specific
range.
can
serve
as
viable
therapeutic
approach
reducing
risk
diabetes
Chronobiology International,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Фев. 11, 2025
This
study
aimed
to
investigate
the
associations
between
chrononutrition
profile,
social
jet
lag
(SJL)
with
obesity-related
indicators
(body
mass
index
(BMI),
waist
circumference
(WC),
waist-to-height
ratio
(WHTR),
and
percentage
of
body
fat
(PBF)).
cross-sectional
was
conducted
among
college
students
in
a
university
Hunan
Province,
China,
from
14
September
2023
8
June
2024.
employed
Chrononutrition
Profile
–
Questionnaire
(CP-Q)
along
physical
examinations.
SJL
defined
as
time
difference
midpoint
sleep
workdays
freedays.
Sleep-corrected
(SJLsc)
is
absolute
onset
on
free
days
workdays.
Average
evening
latency
last
meal
day
bedtime.
Eating
eating
window
Logistic
regression
utilized
assess
SJL,
students.
A
total
805
participants
were
recruited,
which
695
have
complete
data
after
excluding
those
who
did
not
meet
inclusion
criteria.
After
adjusting
for
potential
covariates,
average
<4
h
related
lower
risk
high
BMI,
WC,
PBF
[OR
(95%
CI)
=
0.435
(0.285–0.663),
0.508
(0.305–0.848),
0.564
(0.402–0.792),
respectively].
>12
associated
0.511
(0.327–0.800),
0.485
(0.277–0.851),
0.651
(0.456–0.930),
Last
occasion
>1
higher
1.554
(1.018–2.371)].
SJLsc
>
1
1.527
(1.073–2.174)].
Circadian
rhythm
disruptions,
including
lag,
are
prevalent
Long
window,
short
latency,
low
obesity,
while
duration,
larger
obesity
youths.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 24, 2025
Overweight
and
obesity
are
linked
to
mitochondrial
alterations,
impaired
glucose
tolerance
a
high
risk
of
type
2
diabetes.
Time-restricted
eating
(TRE)
may
aid
in
facilitating
weight
loss
prevent
Here,
we
investigated
if
TRE
individuals
with
overweight
prediabetes
or
affects
bioenergetics
peripheral
blood
mononuclear
cells
(PBMCs)
platelets
using
the
Seahorse
extracellular
flux
technology.
In
3-month
randomized
controlled
trial,
PBMCs/platelets
were
analyzed
from
52
participants
before
after
intervention
10-h
window
habitual
living.
PBMC
platelet
respiratory
function
was
evaluated
through
sequential
addition
substrates,
uncouplers,
inhibitors
living
cells.
After
3
months,
there
no
statistically
significant
differences
respiration
within
between
control
groups.
Association
analyses
PBMC/platelet
clinical
parameters
including
body
mass
index
fat
showed
effects.
conclusion,
months
does
not
alter
PBMCs
Communications Biology,
Год журнала:
2025,
Номер
8(1)
Опубликована: Март 26, 2025
Abstract
The
circadian
clock
is
a
transcriptional-translational
feedback
loop
which
oscillates
in
virtually
all
nucleated
cells
of
the
body.
In
decades
since
its
discovery,
it
has
become
evident
that
molecular
clockwork
inextricably
linked
to
energy
metabolism.
Given
frequency
with
metabolic
dysfunction
and
disruption
co-occur,
understanding
why
how
processes
are
reciprocally
coupled
will
have
important
implications
for
supporting
human
health
wellbeing.
Here,
we
discuss
relevance
function
tissues
explore
role
not
only
as
driver
day-night
variation
gene
expression,
but
key
mechanism
maintaining
homeostasis
face
fluctuating
supply
demand.
npj Metabolic Health and Disease,
Год журнала:
2025,
Номер
3(1)
Опубликована: Апрель 9, 2025
Most
aspects
of
physiology
and
behaviour
fluctuate
every
24
h
in
mammals.
These
circadian
rhythms
are
orchestrated
by
an
autonomous
central
clock
located
the
suprachiasmatic
nuclei
that
coordinates
timing
cellular
clocks
tissues
throughout
body.
The
critical
role
this
system
is
emphasized
increasing
evidence
associating
disruption
with
diverse
pathologies.
Accordingly,
mounting
suggests
a
bidirectional
relationship
where
misalignment
may
contribute
to
liver
diseases
while
alter
other
tissues.
Therefore,
pathophysiology
broadly
impact
provide
mechanistic
framework
for
understanding
targeting
metabolic
adjust
setpoints.
Diabetes Obesity and Metabolism,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Anti‐obesity
medications
have
reached
new
heights
in
terms
of
efficacy,
with
presently
available
pharmacological
options
almost
reaching
the
efficacy
surgical
techniques,
and
thus
these
are
starting
to
fill
treatment
void.
Because
increased
weight
loss
benefits
on
a
host
obesity
complications
being
reported,
prevention
diabetes,
reduction
liver
cardiovascular
improvements
osteoarthritis
among
prominent
features.
On
other
hand,
present
anti‐obesity
strategies
also
lead
lean
bone
mass,
while
consequences
hereof
only
beginning
present,
they
highly
likely
be
importance
target
population
that
contains
large
number
elderly
potentially
frail
individuals.
Therefore,
there
is
need
address
issue
quality,
both
context
existing
possibilities,
but
especially
myriad
novel
horizon.
Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4426 - 4426
Опубликована: Дек. 23, 2024
Time-restricted
eating
(TRE)
shows
promise
for
managing
weight
and
metabolic
issues,
yet
its
application
in
real-world
healthcare
settings
remains
underexplored.
This
study
aims
to
assess
the
utilisation
short-term
outcomes
of
TRE
clinical
practice.
observational
used
a
retrospective
chart
review
271
adults
who
attended
specialist
clinic
between
2019
2023.
Descriptive
statistics
multivariable
logistic
regression
were
identify
factors
associated
with
adoption,
while
paired
sample
Among
patients,
76%
female,
90%
Caucasian,
94%
overweight/obese.
Of
all
47.2%
received
advice,
mainly
using
16:8
method,
alongside
additional
dietary
guidance
60%
patients.
Working
status
baseline
profiles
only
significantly
adoption.
those
followed
TRE,
81%
experienced
modest
but
significant
reductions
(-1.2
kg,
highlights
as
feasible
practical
strategy
improving
health
settings.
However,
further
research
improved
data
capture
are
needed
explore
long-term
adherence,
potential
adverse
effects,
effectiveness
across
diverse
patient
populations.
Clinical Science,
Год журнала:
2024,
Номер
138(21), С. 1343 - 1356
Опубликована: Окт. 24, 2024
Abstract
It
has
been
recognized
for
over
a
century
that
feeding
animals
less
food
than
they
would
normally
eat
increases
lifespan
and
leads
to
broad-spectrum
improvements
in
age-related
health.
A
significant
number
of
studies
have
subsequently
shown
restricting
total
protein,
branched
chain
amino
acids
or
individual
the
diet,
as
well
ketogenic
diets,
can
elicit
similar
effects.
In
addition,
it
is
becoming
clear
fasting
protocols,
such
time-restricted-feeding
every-other-day
feeding,
without
changes
overall
energy
intake
also
profoundly
affect
rodent
longevity
late-life
this
review,
I
will
provide
historical
perspective
on
various
dietary
interventions
modulate
ageing
rodents
discuss
how
understanding
exposome
may
help
identify
future
strategies
maintain
health
wellbeing
humans.
