Exploring the effects of time-restricted eating on body weight and associated cardiometabolic outcomes in South African women living with HIV (TESSA): protocol for a randomised controlled trial

BMJ Open, Год журнала: 2024, Номер 14(12), С. e086203 - e086203

Опубликована: Дек. 1, 2024

Introduction We codesigned an intervention with a low-resourced community the aim to investigate effects of time-restricted eating (TRE) on changes in body weight and associated cardiometabolic outcomes South African women living overweight/obesity HIV who have initiated dolutegravir (DTG)-based antiretroviral therapy (ART). Methods analysis Women overweight or obesity (body mass index ≥25 kg/m², no upper limit), aged 20–45 years, community, receiving DTG-based ART for less than 2 years will be recruited from healthcare centre Khayelitsha, Cape Town (n=152). Participants randomised 1:1 TRE group (n=76) standard care control 12 months. The required restrict their window ~8–10 hours/day receive nutritional information sessions at baseline 3, 6, 9 primary outcome assessed monthly. Cardiometabolic measures reported as secondary outcomes. At baseline, 6- months, oral glucose tolerance test (to estimate insulin sensitivity beta-cell function), questionnaires (sociodemographic, food insecurity, quality life, social support sleep quality) quantified frequency questionnaire (total energy macronutrient composition) completed. Every 3 appetite ratings, bioelectrical impedance (fat fat-free mass), fasting venous bloods (glucose, insulin, gut hormones systemic inflammation) process evaluation (qualitative interviews) Monthly monitoring also include anthropometry blood pressure. Ethics dissemination study is conducted accordance Declaration Helsinki has been approved by Human Research Committee University (628/2021). Verbal written consent participants. Results this published peer-reviewed journals presented conferences. Trial registration number PACTR202302484999720.

Язык: Английский

Effect of Aerobic Exercise on Blood Glucose Among Those with Prediabetes: A Systematic Review and Meta-Analysis

Life, Год журнала: 2024, Номер 15(1), С. 32 - 32

Опубликована: Дек. 30, 2024

Prediabetes, a state between normoglycemia and diabetes, is increasingly affecting population health; thus, it should not be overlooked. This systematic review meta-analysis aimed to explore the efficacy of aerobic exercise on blood glucose indicators among those with prediabetes. Five databases, including PubMed, Embase, Cochrane Library, Web Science, CINAHL, were searched up September 2024 identify randomized controlled trials measuring effect levels individuals Data fasting (FBG), 2-h postprandial plasma (2hPG), hemoglobin A1c (HbA1c) extracted. Subgroup analyses conducted based intervention duration, weekly volume. In total, 2518 relevant records initially retrieved, 16 studies included in this review, 14 providing sufficient data for meta-analysis. Compared control group, weighted mean difference (MD) FBG, 2hPG, HbA1c was −1.33 (95%CI: −1.87, −0.89), −1.00 −1.60, −0.39), −1.05 −1.49, −0.61), respectively. analysis showed that pooled size greater subgroup subjected ≥48 weeks compared ≤24 intervention, although only FBG significant (p < 0.05). Weekly longer than 180 min/week led reductions shorter 150 min/week, differences 2hPG > Total 1314–1323 MET·min/week 975–1080 Aerobic effectively decreases controls levels. The volume duration are important factors reduction levels, exhibiting positive correlation within specific range. can serve as viable therapeutic approach reducing risk diabetes

Язык: Английский