(Re)Moving the needle: a retrospective, quasi-experimental assessment of the impact of a treatment guideline on oral antibiotic prescribing for orthopedic infections DOI Creative Commons
Russell J Benefield, Chanah K. Gallagher, Julie Gray

и другие.

Antimicrobial Stewardship & Healthcare Epidemiology, Год журнала: 2025, Номер 5(1)

Опубликована: Янв. 1, 2025

Abstract Objective: Despite many reports of similar effectiveness between oral and intravenous antibiotics for bone joint infections, prescribing practice has been slow to change in the United States. We sought determine if implementing an intravenous-to-oral treatment guideline could increase antibiotic regimens at our center. Design: Retrospective, quasi-experimental study. Setting: Single US academic medical Patients: Patients with or infections managed by Infectious Disease providers from September 2020 December 2022. Intervention: An patients infections. Methods: The rates fully before after implementation were compared. Additionally, variables independently associated identified logistic regression. Results: There 450 included: 213 237 guideline. Oral significantly increased following 59% 33% (difference 25.8%, 95% CI [16.7%, 34.4%]. In multivariable analysis, post-intervention phase was a greater likelihood (aOR 2.89 [1.90, 4.45]). Other included male sex 1.88 [1.20, 2.98]), prosthetic infection 0.29 [0.17, 0.47]), Enterobacterales 2.86 [1.45, 5.92]), methicillin-sensitive Staphylococcus aureus [aOR 0.41 [0.26, 0.65]), coagulase-negative staphylococci 0.34 [0.18, 0.62]). Conclusions: Implementation resulted significant prescribing. Antimicrobial stewardship programs should implement interventions improve outpatient utilization.

Язык: Английский

Implementing oral antibiotics for bone and joint infections: Lessons learned and opportunities for improvement DOI Creative Commons
Marten R Hawkins, Elizabeth Thottacherry, Prerak Juthani

и другие.

Open Forum Infectious Diseases, Год журнала: 2024, Номер 11(12)

Опубликована: Ноя. 16, 2024

Although intravenous antibiotics have historically been the standard of care for bone and joint infections, clinical trial data highlighted safety efficacy oral antibiotics. Despite this, are still commonly used, evaluations institutional guidelines advancing antibiotic use limited.

Язык: Английский

Процитировано

5
(Re)Moving the needle: a retrospective, quasi-experimental assessment of the impact of a treatment guideline on oral antibiotic prescribing for orthopedic infections DOI Creative Commons
Russell J Benefield, Chanah K. Gallagher, Julie Gray

и другие.

Antimicrobial Stewardship & Healthcare Epidemiology, Год журнала: 2025, Номер 5(1)

Опубликована: Янв. 1, 2025

Abstract Objective: Despite many reports of similar effectiveness between oral and intravenous antibiotics for bone joint infections, prescribing practice has been slow to change in the United States. We sought determine if implementing an intravenous-to-oral treatment guideline could increase antibiotic regimens at our center. Design: Retrospective, quasi-experimental study. Setting: Single US academic medical Patients: Patients with or infections managed by Infectious Disease providers from September 2020 December 2022. Intervention: An patients infections. Methods: The rates fully before after implementation were compared. Additionally, variables independently associated identified logistic regression. Results: There 450 included: 213 237 guideline. Oral significantly increased following 59% 33% (difference 25.8%, 95% CI [16.7%, 34.4%]. In multivariable analysis, post-intervention phase was a greater likelihood (aOR 2.89 [1.90, 4.45]). Other included male sex 1.88 [1.20, 2.98]), prosthetic infection 0.29 [0.17, 0.47]), Enterobacterales 2.86 [1.45, 5.92]), methicillin-sensitive Staphylococcus aureus [aOR 0.41 [0.26, 0.65]), coagulase-negative staphylococci 0.34 [0.18, 0.62]). Conclusions: Implementation resulted significant prescribing. Antimicrobial stewardship programs should implement interventions improve outpatient utilization.

Язык: Английский

Процитировано

0