Methamphetamine (MA) use and MA-induced psychosis are associated with increasing aberrations in the compensatory immunoregulatory system, interleukin-1α, and CCL5 levels DOI
Rasmon Kalayasiri,

Kanokwan Dadwat,

Supaksorn Thika

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Июнь 24, 2023

Abstract Comprehensive immunological profiles have not been studied in relation to methamphetamine (MA) use, MA dependency, or MA-induced psychosis (MAP). Using the BioPlex Pro Human Cytokine 48-Plex panel, this study measured M1 macrophage, T helper (Th)-1, Th-2, growth factor, and chemokine profiles, as well immune inflammatory response system (IRS) compensatory immunoregulatory (CIRS) peripheral blood samples from patients with use (n=51), dependence (n=47), MAP (n=43) comparison healthy controls (n=43). We discovered that persistent had a robust dose-dependent suppressive impact on all suggesting extensive immunosuppression. The most reliable biomarker profile of is combination substantial CIRS suppression rise selected pro-inflammatory cytokines, namely CCL27 (CTACK), CCL11 (eotaxin), interleukin (IL)-1α. In addition, dependency related more severe immunosuppression, demonstrated by lower stem cell factor higher IL-10 levels. significant decrease particularly CIRS, an increase CCL5 (RANTES), IL-1α, IL-12p70 signaling. conclusion, long-term severely undermine homeostasis. This results widespread which may likelihood infectious illness exacerbate disorders such hepatitis AIDS. Elevated levels CCL5, CCL11, CCL27, and/or be associated (atherosclerosis, cutaneous inflammation, aberrations, hypospermatogenesis) central (neuroinflammation, neurotoxic, neurodegenerative, depression, anxiety psychosis) side effects.

Язык: Английский

The effects of adverse childhood experiences on depression and suicidal behaviors are partially mediated by neuroticism: A subclinical manifestation of major depression DOI Creative Commons
Ketsupar Jirakran, Asara Vasupanrajit, Chavit Tunvirachaisakul

и другие.

Frontiers in Psychiatry, Год журнала: 2023, Номер 14

Опубликована: Апрель 26, 2023

Neuroticism, a personality trait, can predict major depressive disorder (MDD). The current study aims to determine whether a) neuroticism is feature of the acute state MDD, including suicidal behaviors (SB); and b) adverse childhood experiences (ACEs) are associated with in MDD.

Язык: Английский

Процитировано

20
The Gold Standard Diagnosis of Schizophrenia is Counterproductive: Towards Quantitative Research and Diagnostic Algorithmic Rules (RADAR) and their Derived Qualitative Distinct Classes DOI Creative Commons
Michaël Maes

Current Topics in Medicinal Chemistry, Год журнала: 2024, Номер 24(20), С. 1799 - 1815

Опубликована: Апрель 22, 2024

: Recently, we developed Research and Diagnostic Algorithm Rules (RADAR) to assess the clinical pathway features of mood disorders. The aims this paper are review a) methodology for developing continuous RADAR scores that describe schizophrenia, b) a new method visualize status patients pathways implicated in graphs. We how interpret scores, which serve as valuable tools monitoring staging illness, lifetime suicidal behaviors, overall severity general cognitive decline index, behavior-cognitive-psychosocial (BCPS) index represents “defect”; reflect various protective (including compensatory immune- inflammatory system) adverse neuro-immune, neuro-oxidative, neurotoxic biomarkers) outcome pathways. Using machine learning, created new, qualitatively different types such major neurocognitive psychosis simple psychosis. also made graphs, give us quick way compare patient's condition those healthy controls. generated personalized fingerprint each patient, encompassing disorder represented through latter is utilized practice identify treatment-required mitigate risk recurrent episodes, worsening BCPS, increasing staging. quantitative should be used schizophrenia research dependent variables regressed on scores.

Язык: Английский

Процитировано

5
Methamphetamine (MA) use and MA-induced psychosis are associated with increasing aberrations in the compensatory immunoregulatory system, interleukin-1α, and CCL5 levels DOI Creative Commons
Rasmon Kalayasiri,

Kanokwan Dadwat,

Supaksorn Thika

и другие.

Translational Psychiatry, Год журнала: 2023, Номер 13(1)

Опубликована: Ноя. 23, 2023

There are only a few studies reporting on the immunological profiles of methamphetamine (MA) use, MA dependency, or MA-induced psychosis (MAP). This study measured M1 macrophage, T helper (Th)-1, Th-2, growth factor, and chemokine profiles, as well immune inflammatory response system (IRS) compensatory immunoregulatory (CIRS) in peripheral blood samples from patients with use (n = 51), dependence 47), MAP 43) comparison controls 32). We discovered that persistent had robust immunosuppressive impact all profiles. The most reliable biomarker profile is combination substantial CIRS suppression rise selected pro-inflammatory cytokines, namely CCL27 (CTACK), CCL11 (eotaxin), interleukin (IL)-1α. In addition, dependency associated increased immunosuppression, demonstrated by lower stem cell factor levels higher IL-10 levels. related to significant decrease particularly CIRS, an increase CCL5 (RANTES), IL-1α, IL-12p70 signaling. conclusion, long-term severely undermine homeostasis, whereas may be consequence IL-1α - signaling superimposed strongly depleted Th-1 functions. widespread immunosuppression established longstanding likelihood infectious illness exacerbate disorders such hepatitis AIDS. Furthermore, elevated CCL5, CCL11, CCL27, and/or play role (atherosclerosis, cutaneous inflammation, aberrations, hypospermatogenesis) central (neuroinflammation, neurotoxic, neurodegenerative, depression, anxiety, psychosis) side effects use.

Язык: Английский

Процитировано

10
In Schizophrenia, the Effects of the IL-6/IL-23/Th17 Axis on Health-Related Quality of Life and Disabilities Are Partly Mediated by Generalized Cognitive Decline and the Symptomatome DOI Open Access

Ali Fattah Al-Musawi,

Hussein Kadhem Al‐Hakeim,

Zahraa Abdulrazaq Al-Khfaji

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(22), С. 15281 - 15281

Опубликована: Ноя. 18, 2022

Schizophrenia patients show increased disabilities and lower quality of life (DisQoL). Nevertheless, there are no data on whether the activation interleukin (IL)-6, IL-23, T helper (Th)-17 axis, magnesium calcium levels impact DisQoL scores. This study recruited 90 with schizophrenia (including 40 deficit schizophrenia) healthy controls assessed World Health Association QoL instrument-Abbreviated version Sheehan Disability scale, Brief Assessment Cognition in (BACS), IL-6, IL-17, IL-21, IL-22, tumor necrosis factor (TNF)-α, calcium. Regression analyses showed that a large part first extracted from physical, psychological, social environmental HR-QoL interference school/work, life, home responsibilities was predicted by generalized cognitive deterioration (G-CoDe) index (a latent vector BACs scores), various symptom domains (“symptomatome”), whereas biomarkers had effects. Partial Least Squares analysis IL6IL23Th17 axis magnesium/calcium highly significant total (indirect + direct) effects HR-QoL/disabilities, which were mediated G-CoDe symptomatome negative positive symptoms). The explained 63.1% variance behavioral-cognitive-psycho-social (BCPS) worsening single trait G-CoDe, symptomatome, disability data. In summary, BCPS is partly caused neuroimmunotoxic subjects lowered antioxidant defenses (magnesium calcium), thereby probably damaging neuronal circuits may underpin schizophrenia.

Язык: Английский

Процитировано

13
Towards a major methodological shift in depression research by assessing continuous scores of recurrence of illness, lifetime and current suicidal behaviors and phenome features: focus on atherogenicity and adverse childhood experiences DOI Creative Commons

Michael Maes,

Ketsupar Jirakran, Asara Vasupanrajit

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Фев. 27, 2023

Abstract Background The binary major depressive disorder (MDD) diagnosis is inadequate and should never be used in research. Aims study’s objective to explicate our novel precision nomothetic strategy for constructing depression models based on adverse childhood experiences (ACEs), lifetime current phenome, biomarker (atherogenicity indices) scores. Methods This study assessed recurrence of illness (ROI: namely episodes suicidal behaviors), behaviors the phenome depression, neuroticism, dysthymia, anxiety disorders, lipid biomarkers (including ApoA, ApoB, free cholesterol cholesteryl esters, triglycerides, high density lipoprotein cholesterol) 67 normal controls 66 MDD patients. We computed atherogenic reverse transport indices. Results were able extract one factor from a) comprising ROI, traits such as dysthymia b) acute phase (based quality life scores). PLS analysis showed that 55.7% variance + was explained by increased atherogenicity, neglect sexual abuse, while atherogenicity partially mediated effects neglect. Cluster generated a cluster patients with dysmood disorder, which externally validated characterized scores all clinical features. Conclusions outcome not represented variable (MDD or not), but rather multiple dimensional biomarkers, subclinical traits, including behaviors.

Язык: Английский

Процитировано

7
Unique Challenges in Biomarkers for Psychotic Disorders DOI Creative Commons
Eric Chen, Stephanie Ming Yin Wong

Brain Sciences, Год журнала: 2024, Номер 14(1), С. 106 - 106

Опубликована: Янв. 22, 2024

Biomarkers are observations that provide information about the risk of certain conditions (predictive) or their underlying mechanisms (explanatory) [...]

Язык: Английский

Процитировано

2
Chronic fatigue syndrome, depression, and anxiety symptoms due to relapsing-remitting multiple sclerosis are associated with reactivation of Epstein-Barr virus and Human Herpesvirus 6. DOI Creative Commons
Michaël Maes, Abbas F. Almulla, Elroy Vojdani

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Relapsing-remitting multiple sclerosis (RRMS) is defined by elevated IgG/IgA/IgM responses targeting Epstein-Barr Virus (EBV) nuclear antigen 1 (EBNA) and deoxyuridine-triphosphatases (dUTPases) of Human herpsesvirus-6 (HHV-6) EBV. These suggest that the viruses are being replicated reactivated. An increased prevalence chronic fatigue syndrome, depression, anxiety associated with signs immune activation in RRMS. Nevertheless, there a lack data regarding association between viral reactivation neuropsychiatric symptoms This study investigated to EBNA, EBV HHV-6-dUTPases, 58 remitted RRMS patients 63 normal controls. The McDonald criteria were employed establish diagnosis MS. Expanded Disability Status Scale (EDSS) Multiple Sclerosis Severity Score evaluate disabilities caused We evaluated scores Hamilton Depression (HAMD) Anxiety (HAMA) Rating Scales, Fibro-Fatigue (FF) scale. One latent construct was extracted from EDSS, MSSS, FF, HAMD, HAMA scores. discovered combined effects IgG IgM-HHV-6-dUTPAses accounted for 63.7% variance this construct. Furthermore, total HAMA, HAMD substantially IgM-HHV-6-dUTPAses, accounting approximately 38.7% 51.0% variance. three rating scale also significantly correlated IgA reactivity directed both dUTPases EBNA. replication HHV-6 contributes as well depression due

Язык: Английский

Процитировано

2
The General Neurocognitive Decline in Patients with Methamphetamine Use and Transient Methamphetamine-induced Psychosis is Primarily Determined by Oxidative and AGE-RAGE Stress DOI
Michaël Maes,

Mazin Fadhil Altufaili,

Amer Fadhil Alhaideri

и другие.

Current Topics in Medicinal Chemistry, Год журнала: 2024, Номер 24(20), С. 1816 - 1828

Опубликована: Июль 10, 2024

Chronic Methamphetamine (MA) usage is linked to oxidative and AGE (advanced glycation end products) - RAGE (receptors for AGEs) stress, changes in magnesium, calcium, copper, increased psychotic symptoms, neurocognitive deficits. Nevertheless, it still unclear whether these biological pathways mediate the latter impairments.

Язык: Английский

Процитировано

1
The novel schizophrenia subgroup “major neurocognitive psychosis” is validated as a distinct class through the analysis of immune-linked neurotoxicity biomarkers and neurocognitive deficits DOI Creative Commons
Petar Popov, Chen Chen, Hussein Kadhem Al‐Hakeim

и другие.

Brain Behavior & Immunity - Health, Год журнала: 2024, Номер 40, С. 100842 - 100842

Опубликована: Авг. 14, 2024

Using machine learning methods based on neurocognitive deficits and neuroimmune biomarkers, two distinct classes were discovered within schizophrenia patient samples. Increased frequency of psychomotor retardation, formal thought disorders, mannerisms, psychosis, hostility, excitation, negative symptoms defined the first subgroup, major psychosis (MNP). Cognitive in executive functions memory diverse aberrations other MNP features. Simple (SNP) was less severe phenotype.

Язык: Английский

Процитировано

1
Methamphetamine (MA) use, MA dependence, and MA-induced psychosis are associated with increasing aberrations in the compensatory immunoregulatory system and interleukin-1α and CCL5 levels DOI Open Access
Rasmon Kalayasiri,

Kanokwan Dadwat,

Supaksorn Thika

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Март 29, 2023

Abstract Comprehensive immunological profiles have not been studied in relation to methamphetamine (MA) use, MA dependency, or MA-induced psychosis (MAP). Using the BioPlex Pro Human Cytokine 48-Plex panel, this study measured M1 macrophage, T helper (Th)-1, Th-2, growth factor, and chemokine profiles, as well immune inflammatory response system (IRS) compensatory immunoregulatory (CIRS) peripheral blood samples from patients with use (n=51), dependence (n=47), MAP (n=43) comparison healthy controls (n=43). We discovered that persistent had a robust dose-dependent suppressive impact on all suggesting extensive immunosuppression. The most reliable biomarker profile of is combination substantial CIRS suppression rise selected pro-inflammatory cytokines, namely CCL27 (CTACK), CCL11 (eotaxin), interleukin (IL)-1α. In addition, dependency related more severe immunosuppression, demonstrated by lower stem cell factor higher IL-10 levels. significant decrease particularly CIRS, an increase CCL5 (RANTES), IL-1α, IL-12p70 signaling. conclusion, long-term severely undermine homeostasis. This results widespread which may likelihood infectious illness exacerbate disorders such hepatitis AIDS. Elevated levels CCL5, CCL11, CCL27, and/or be associated (atherosclerosis, cutaneous inflammation, aberrations, hypospermatogenesis) central (neuroinflammation, neurotoxic, neurodegenerative, depression, anxiety psychosis) side effects. Our message: “cease using MA, better yet, never begin MA”.

Язык: Английский

Процитировано

1